Abstract: It is provided the use of Pyrimido[4,5-B]indole derivatives as anti-cancer compounds, and more specifically the use of UM171 and its derivatives for treating cancer, by activating the CULLIN3-RING ubiquitin ligase complex which degrades RCOR1 which normally acts as the scaffolding protein for the RCOR1/LSD1 and HDAC2 complex, itself being dissociated in the presence of UM171. Thus UM171 acts like a molecular glue degrader, inhibiting HDACs, RCOR1, CoREST and LSD1 and resulting in an anti-cancer activity.

Abstract: The invention relates to a side protection device to prevents road users and/or pedestrians to slip, move and/or enter under a vehicle. The device comprises a first member adapted to be secured, under a lateral side of the vehicle; a second member adapted to be secured, under a same lateral side of the vehicle; at least one flexible, elongated member having a first end and a second end opposite to the first end; at least one connecting means for securing the first end of the at least one flexible, elongated member to the first member or the second member; and at least one connecting/tensioning means for securing and tensioning the at least one flexible, elongated member between the first member and the second member. The invention also relates to a vehicle provided with the above device and a kit comprising at least one of the above device.

Abstract: The invention relates to a side protection device to prevents road users and/or pedestrians to slip, move and/or enter under a vehicle. The device comprises a first member adapted to be secured, under a lateral side of the vehicle; a second member adapted to be secured, under a same lateral side of the vehicle; at least one flexible, elongated member having a first end and a second end opposite to the first end; at least one connecting means for securing the first end of the at least one flexible, elongated member to the first member or the second member; and at least one connecting/tensioning means for securing and tensioning the at least one flexible, elongated member between the first member and the second member. The invention also relates to a vehicle provided with the above device and a kit comprising at least one of the above device.

Abstract: A method of optically imaging an object includes the determination of a source point and a destination point within the object. Planar boundaries are selected that approximate a geometrical shape of the object, and virtual sources are found using a reflection of the original source through the boundaries. Subsequent reflections of the added sources may be used to find higher order sources. Contributions to an optical transfer function from each of the added sources are added to determine a cumulative optical transfer function until a convergence limit is reached. The resulting optical transfer function is more accurate than the original in that it takes boundary phenomena into consideration.

Abstract: A fluorescence optical tomography system and method uses a photon migration model calculator for which absorption and reduced scattering coefficient values are determined for each source/detector pair. The coefficient values may be determined by measurement, in which a time resolved detector detects the excitation wavelength and generates temporal point spread functions from which the coefficient values are found. Alternatively, the coefficient values may be determined by calculating them from a dataset containing a spatial distribution of absorption and reduced scattering coefficients in a volume of interest. The fluorescence detection may be continuous wave, time resolved, or a combination of the two. An estimator uses a detected fluorescence signal and an estimated fluorescence signal to estimate the image values.

Abstract: A method of optically imaging an object includes the determination of a source point and a destination point within the object. Planar boundaries are selected that approximate a geometrical shape of the object, and virtual sources are found using a reflection of the original source through the boundaries. Subsequent reflections of the added sources may be used to find higher order sources. Contributions to an optical transfer function from each of the added sources are added to determine a cumulative optical transfer function until a convergence limit is reached. The resulting optical transfer function is more accurate than the original in that it takes boundary phenomena into consideration.

Abstract: A fluorescence optical tomography system and method uses a photon migration model calculator for which absorption and reduced scattering coefficient values are determined for each source/detector pair. The coefficient values may be determined by measurement, in which a time resolved detector detects the excitation wavelength and generates temporal point spread functions from which the coefficient values are found. Alternatively, the coefficient values may be determined by calculating them from a dataset containing a spatial distribution of absorption and reduced scattering coefficients in a volume of interest. The fluorescence detection may be continuous wave, time resolved, or a combination of the two. An estimator uses a detected fluorescence signal and an estimated fluorescence signal to estimate the image values.