Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: An anesthetic container includes a receptacle for holding the anesthetic and having a wall defining an interior space and a passage in fluid communication with the interior space. The container also includes a valve assembly that is attachable or is attached to the receptacle to control flow of anesthetic through the passage in the receptacle to a vaporizer. The valve assembly has a closed configuration when the flow of anesthetic from the receptacle is limited and an open configuration when the flow of anesthetic is enabled. The valve assembly is constructed so that at least the surface of any component of the assembly that will come into contact with the anesthetic on its storage or passage from the receptacle to the vaporizer is made of a metal or low-density polyethylene, and provides a fluid-tight seal to prevent the escape of the anesthetic without the use of a gasket in the closed configuration.

Abstract: A system includes a container and an adapter. The container may include a wall defining a receptacle and a neck, the neck forming an opening and a passage in fluid communication between the receptacle and the opening; a closure assembly having a portion disposed within the neck, and including an insert defining a valve seat, an actuator, a valve member attached to the actuator and sealingly engageable with the valve seat, and a biasing member disposed between the insert and the actuator. The biasing member urges the valve member into sealing engagement with the valve seat in an actuator advanced state, and the valve member disengages from the valve seat in an actuator retracted state, the actuator depending through the opening in the advanced state. The adapter may be removably attached to the container, and configured to move the actuator from advanced to retracted state upon attachment.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: An adapter includes a base connectable to an anesthetic agent container, a spout that extends from the base and defines at least one flow path therethrough, and a valve assembly disposed within the at least one flow path, the valve assembly being moveable between a first open position and a second closed position. The adapter also includes a radially expandable seal disposed about the spout, the seal having a first end, a second end, and an intermediate region between the first and second ends that expands radially outward relative to a longitudinal axis of the spout. The valve assembly has a surface that cooperates with the seal, wherein the cooperation between the surface and the seal expands the intermediate region radially outward relative to the longitudinal axis with the valve assembly in the first position.

Abstract: An adapter includes a base connectable to an anesthetic agent container, a spout that extends from the base and defines at least one flow path therethrough, and a valve assembly disposed within the at least one flow path, the valve assembly being moveable between a first open position and a second closed position. The adapter also includes a radially expandable seal disposed about the spout, the seal having a first end, a second end, and an intermediate region between the first and second ends that expands radially outward relative to a longitudinal axis of the spout. The valve assembly has a surface that cooperates with the seal, wherein the cooperation between the surface and the seal expands the intermediate region radially outward relative to the longitudinal axis with the valve assembly in the first position.

Abstract: An anesthetic container includes a receptacle for holding the anesthetic and having a wall defining an interior space and a passage in fluid communication with the interior space. The container also includes a valve assembly that is attachable or is attached to the receptacle to control flow of anesthetic through the passage in the receptacle to a vaporizer. The valve assembly has a closed configuration when the flow of anesthetic from the receptacle is limited and an open configuration when the flow of anesthetic is enabled. The valve assembly is constructed so that at least the surface of any component of the assembly that will come into contact with the anesthetic on its storage or passage from the receptacle to the vaporizer is made of a metal or low-density polyethylene, and provides a fluid-tight seal to prevent the escape of the anesthetic without the use of a gasket in the closed configuration.

Abstract: A pharmaceutical product includes a container. The container, in turn, includes a receptacle having a wall including a layer of nickel or nickel alloy, the layer facing an interior of the receptacle. The product also includes a halogenated anesthetic selected from the group consisting of sevoflurane, desflurane, isoflurane, enflurane, methoxyflurane and halothane disposed within the container.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: Adapters are provided for establishing fluid communication between an anesthetic agent container and an anesthetic vaporizer having a fluid port. The adapter may be mountable on the vaporizer to cooperate with the spout of an anesthetic agent container or may be mountable on an anesthetic agent container to cooperate with the fluid port of an anesthetic vaporizer to provide a sealing and/or retaining relationship therebetween.

Abstract: The present invention is directed to containers with a retaining member disposed within the container which substantially obstructs the opening of the container. In a preferred embodiment of the invention said member enlarges to receive a dispensing instrument that is used to cap the container.

Abstract: A holder for retaining an endotracheal tube in a patient's mouth includes a pair of opposed members constructed to define a lumen when positioned adjacent each other, and a latching device constructed to allow the relative position of the opposed members to be adjusted between a first position in which said lumen is sufficiently small to securely hold the endotracheal tube, and a second position in which the lumen is sufficiently large to allow the endotracheal tube to move axially yet sufficiently small to resist radial displacement of the endotracheal tube. In use, the endotracheal tube is inserted through a patient's mouth into the tracheal lumen, the latching device is moved to its second position, the tube holder is slid over the endotracheal tube and its position adjusted axially along the length of the tube, and the latching device is moved to its first position to secure the tube holder firmly in a desired position on the endotracheal tube.

Abstract: Containers a retaining member disposed within the container which substantially obstructs the opening of the container are disclosed. In a preferred embodiment, the member enlarges to receive a dispensing instrument that is used to cap the container.

Abstract: The present invention is directed to containers with a retaining member disposed within the container which substantially obstructs the opening of the container. In a preferred embodiment of the invention said member enlarges to receive a dispensing instrument that is used to cap the container.