Abstract: Polypeptides, nucleic acid molecules, vectors, cells, fusion proteins, pharmaceutical compositions, combined preparations, and their use as vaccines against influenza are described. The polypeptides comprise a haemagluttinin subtype 5 (H5) globular head domain, and optionally a haemagluttinin stem domain, wherein the polypeptide comprises an amino acid sequence in which an amino acid residue at a position corresponding to residue position 144 or 145 of a wild-type H5 globular head domain has been deleted, or wherein the polypeptide comprises an amino acid sequence with an E amino acid residue at a position corresponding to residue position 238 of a wild-type H5 globular head domain.

Abstract: Methods, systems, computer-readable media, and apparatuses for providing mobile device management (MDM) functionalities are presented. In some embodiments, a pseudo device representative of a physical end user device may be established within a cloud computing environment. The pseudo device may be provisioned for use with MDM service providers and configured to receive commands from the MDM service providers on behalf of the physical end user device. In some embodiments, multiple pseudo devices each representative of a physical end user device may be established within a cloud computing environment. A first pseudo device may be provisioned for use with a first MDM service provider and configured to receive commands from the first MDM service provider on behalf of the physical end user device. A second pseudo device may be provisioned for use with a second MDM service provider and configured to receive commands from the second MDM service provider.

Abstract: This invention relates to a transgenic vector for transducing cells of a mammal's CNS and transgenically expressing a protein in the mammal's CNS. The transgenic vector comprises a virus-derived vector, a nucleic acid sequence encoding the protein, and an endogenous ATP1A3 promoter sequence. This invention also relates to a composition comprising a recombinant AAV vector comprising a nucleic acid sequence encoding a ATP1A3 protein, in a form compatible with administration into the CNS. The invention also relates to a method for treating a subject having a neurological disorder associated with mutations in the ATP1A3 gene and a method for delivering a transgenic ATP1A3 DNA to the central nervous system of a mammal by administering the recombinant AAV vector into the mammal's CNS.

Abstract: This invention relates to a transgenic vector for transducing cells of a mammal's CNS and transgenically expressing a protein in the mammal's CNS. The transgenic vector comprises a virus-derived vector, a nucleic acid sequence encoding the protein, and an endogenous ATP1A3 promoter sequence. This invention also relates to a composition comprising a recombinant AAV vector comprising a nucleic acid sequence encoding a ATP1A3 protein, in a form compatible with administration into the CNS. The invention also relates to a method for treating a subject having a neurological disorder associated with mutations in the ATP1A3 gene and a method for delivering a transgenic ATP1A3 DNA to the central nervous system of a mammal by administering the recombinant AAV vector into the mammal's CNS.

Abstract: Methods and systems for connecting client devices to anonymous sessions via helpers are described herein. One or more anonymous sessions may be generated on one or more target machines. Configuration information for generating an anonymous session may be used to initiate generation of the anonymous session on a target machine. A helper process may be created and associated with the anonymous session. A request to start a virtual application or desktop may be received from a client device, and the client device may be connected to the anonymous session on the target machine. The helper associated with the anonymous session may retrieve credentials associated with a user of the client device and/or may use the credentials associated with the user to start the virtual application or desktop on the target machine as the user.

Abstract: Methods and systems for caching data for resources using a shared cache are described herein. The data may be stored in a configuration service, in the resources, or in the shared cache. The data stored in the configuration service may be modified. The data stored in the resources and in the shared cache may be updated according to the modified data in the configuration service. The data stored in the configuration service, in the resources, or in the shared cache may be used based on an operation mode.

Abstract: Methods, systems, computer-readable media, and apparatuses may provide for the intermediated retrieval of applications on a network. A computing device may be configured to receive an application from an application server on a network. Based on, for example, the network conditions between the computing device and the application server, the computing device may query a plurality of intermediary servers. Based on a decision that, for example, the network conditions between the computing device, application server, and a selected intermediary server are better than the network conditions between the computing device and the application server, the computing device may cause the application to be retrieved by a host application of the selected intermediary server. The host application may process and transmit the application to the computing device. The computing device may display the processed application and transmit user input corresponding to the processed application to the intermediary server.

Abstract: Methods and systems for caching data for resources using a shared cache are described herein. The data may be stored in a configuration service, in the resources, or in the shared cache. The data stored in the configuration service may be modified. The data stored in the resources and in the shared cache may be updated according to the modified data in the configuration service. The data stored in the configuration service, in the resources, or in the shared cache may be used based on an operation mode.

Abstract: Methods, systems, computer-readable media, and apparatuses for providing mobile device management (MDM) functionalities are presented. In some embodiments, a pseudo device representative of a physical end user device may be established within a cloud computing environment. The pseudo device may be provisioned for use with MDM service providers and configured to receive commands from the MDM service providers on behalf of the physical end user device. In some embodiments, multiple pseudo devices each representative of a physical end user device may be established within a cloud computing environment. A first pseudo device may be provisioned for use with a first MDM service provider and configured to receive commands from the first MDM service provider on behalf of the physical end user device. A second pseudo device may be provisioned for use with a second MDM service provider and configured to receive commands from the second MDM service provider.

Abstract: Methods and systems for receiving an indication that an application running on a first device is ready to perform a task, determining a device capability associated with performing the task, determining one or more devices associated with a user of the first device, wherein each of the one or more devices is associated with the device capability, selecting, based on the task and one or more user preferences associated with the user, a second device from the one or more devices, and sending an instruction to the second device, wherein the instruction causes the second device to perform the task, are described herein.

Abstract: Methods and systems for caching data for resources using a shared cache are described herein. The data may be stored in a configuration service, in the resources, or in the shared cache. The data stored in the configuration service may be modified. The data stored in the resources and in the shared cache may be updated according to the modified data in the configuration service. The data stored in the configuration service, in the resources, or in the shared cache may be used based on an operation mode.

Abstract: Methods, systems, computer-readable media, and apparatuses for providing mobile device management (MDM) functionalities are presented. In some embodiments, a pseudo device representative of a physical end user device may be established within a cloud computing environment. The pseudo device may be provisioned for use with MDM service providers and configured to receive commands from the MDM service providers on behalf of the physical end user device. In some embodiments, multiple pseudo devices each representative of a physical end user device may be established within a cloud computing environment. A first pseudo device may be provisioned for use with a first MDM service provider and configured to receive commands from the first MDM service provider on behalf of the physical end user device. A second pseudo device may be provisioned for use with a second MDM service provider and configured to receive commands from the second MDM service provider.

Abstract: Methods, systems, computer-readable media, and apparatuses may provide for the intermediated retrieval of applications on a network. A computing device may be configured to receive an application from an application server on a network. Based on, for example, the network conditions between the computing device and the application server, the computing device may query a plurality of intermediary servers. Based on a decision that, for example, the network conditions between the computing device, application server, and a selected intermediary server are better than the network conditions between the computing device and the application server, the computing device may cause the application to be retrieved by a host application of the selected intermediary server. The host application may process and transmit the application to the computing device. The computing device may display the processed application and transmit user input corresponding to the processed application to the intermediary server.

Abstract: Methods for identifying optimized antigenic pathogen polypeptides capable of inducing a broadly neutralizing immune response, and associated T-cell responses, to a pathogen are described, as well as nucleic acid sequences encoding such polypeptides. Methods for determining whether a broadly neutralizing immune response is induced in a subject following immunization with an optimized antigenic pathogen polypeptide, or a nucleic acid encoding the optimized pathogen polypeptide, are also described. Nucleic acid molecules, polypeptides, vectors, cells, fusion proteins, pharmaceutical compositions, and their use as vaccines against pathogens, especially against emerging or re-emerging pathogens (particularly RNA viruses), are also described.

Abstract: Methods, systems, computer-readable media, and apparatuses may provide for the intermediated retrieval of applications on a network. A computing device may be configured to receive an application from an application server on a network. Based on, for example, the network conditions between the computing device and the application server, the computing device may query a plurality of intermediary servers. Based on a decision that, for example, the network conditions between the computing device, application server, and a selected intermediary server are better than the network conditions between the computing device and the application server, the computing device may cause the application to be retrieved by a host application of the selected intermediary server. The host application may process and transmit the application to the computing device. The computing device may display the processed application and transmit user input corresponding to the processed application to the intermediary server.

Abstract: Aspects described herein are directed to the concealment of customer sensitive data in virtual computing arrangements. A local computing platform may receive an object including a customer sensitive object name from a user computing device operating on a same internal domain as the local computing platform. The local computing platform may conceal the customer sensitive object name from a virtual computing platform operating on a domain external from the internal domain. The local computing platform may provide the concealed object name to the virtual computing platform for facilitating object enumeration requests from the user computing device during virtual computing sessions. During a virtual computing session between the user computing device and virtual computing platform, the local computing platform may receive the concealed object name from the user computing device and may perform one or more operations to reveal the object name to the user computing device.

Abstract: Aspects described herein are directed to the concealment of customer sensitive data in virtual computing arrangements. A local computing platform may receive an object including a customer sensitive object name from a user computing device operating on a same internal domain as the local computing platform. The local computing platform may conceal the customer sensitive object name from a virtual computing platform operating on a domain external from the internal domain. The local computing platform may provide the concealed object name to the virtual computing platform for facilitating object enumeration requests from the user computing device during virtual computing sessions. During a virtual computing session between the user computing device and virtual computing platform, the local computing platform may receive the concealed object name from the user computing device and may perform one or more operations to reveal the object name to the user computing device.

Abstract: Methods and systems for connecting client devices to anonymous sessions via helpers are described herein. One or more anonymous sessions may be generated on one or more target machines. Configuration information for generating an anonymous session may be used to initiate generation of the anonymous session on a target machine. A helper process may be created and associated with the anonymous session. A request to start a virtual application or desktop may be received from a client device, and the client device may be connected to the anonymous session on the target machine. The helper associated with the anonymous session may retrieve credentials associated with a user of the client device and/or may use the credentials associated with the user to start the virtual application or desktop on the target machine as the user.

Abstract: Methods and systems for connecting client devices to anonymous sessions via helpers are described herein. One or more anonymous sessions may be generated on one or more target machines. Configuration information for generating an anonymous session may be used to initiate generation of the anonymous session on a target machine. A helper process may be created and associated with the anonymous session. A request to start a virtual application or desktop may be received from a client device, and the client device may be connected to the anonymous session on the target machine. The helper associated with the anonymous session may retrieve credentials associated with a user of the client device and/or may use the credentials associated with the user to start the virtual application or desktop on the target machine as the user.

Abstract: Methods and systems for caching data for resources using a shared cache are described herein. The data may be stored in a configuration service, in the resources, or in the shared cache. The data stored in the configuration service may be modified. The data stored in the resources and in the shared cache may be updated according to the modified data in the configuration service. The data stored in the configuration service, in the resources, or in the shared cache may be used based on an operation mode.