Abstract: The present disclosure relates to a computer-implemented method of determining if a fundus image requires referral for investigation for a disease. The method comprises: performing a pairwise comparison of the fundus image against each example fundus image in a reference image set using one or more machine learning algorithms to determine a difference in severity of the fundus image compared to each example fundus image in the reference image set; and flagging the fundus image as requiring referral for investigation for the disease based on results of the pairwise comparisons, wherein the reference image set includes a plurality of example fundus images, the plurality of example fundus images ranked according to their degree of severity of disease.

Abstract: According to the subject-matter of the present disclosure, there is provided a computer-implemented method of determining if a medical data sample requires referral for investigation for a disease.

Abstract: A signal up-conversion system is described. The system comprises a signal input for receiving an input signal to be up-converted; an oscillator system for generating an up-conversion signal having a selectable frequency; a mixer coupled to the input and to the oscillator, for combining the input signal and the up-conversion signal and to generate an up-converted signal; at least two filters, each of the at least two filters having different filtering characteristics; a signal output; a switch system configured to couple one of the at least two filters into a signal path between the output of the mixer and the signal output; and a controller configured to control a frequency of the up-conversion signal and a filter of the at least two filters coupled into the signal path by the switch system. A method switching between up-conversion frequencies is also described.

Abstract: A flexible hose comprising: a flexible conduit for carrying a pressurized fluid; a flexible inner support for supporting the conduit; and a compression layer surrounding the flexible conduit.

Abstract: A flexible hose comprising: a flexible conduit for carrying a pressurized fluid; a flexible inner support for supporting the conduit; and a compression layer surrounding the flexible conduit.

Abstract: The present invention provides an airfoil a second stage nozzle guide vane having an external surface with first and second sides. The external surface extends spanwise between a hub and a tip and streamwise between a leading edge and a trailing edge of the airfoil. The external surface includes a contour substantially defined by Table 1 as listed in the specification.

Abstract: The present invention provides an airfoil for a second stage turbine blade having an external surface with first and second sides. The external surface extends spanwise between a hub and a tip and streamwise between a leading edge and a trailing edge of the airfoil. The external surface includes a contour substantially defined by Table 1 as listed in the specification.