Patents by Inventor Simon Higginbottom

Simon Higginbottom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein folding
    Patent number: 7893221
    Abstract: The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: February 22, 2011
    Assignee: Renovo Limited
    Inventors: Mark William James Ferguson, Phillip Mellors, Hugh Gerard Laverty, Nick Occleston, Sharon O'Kane, Simon Higginbottom
  • PROTEIN FOLDING
    Publication number: 20090181430
    Abstract: The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta.
    Type: Application
    Filed: March 9, 2007
    Publication date: July 16, 2009
    Inventors: Mark William James Ferguson, Phillip Mellors, Hugh Gerard Laverty, Nick Occleston, Sharon O'Kane, Simon Higginbottom
  • Pharmaceutical Formulations
    Publication number: 20070202161
    Abstract: Capsule formulations are provided containing at least two different fill compositions which are prevented from mixing either by providing both of the fill compositions as solids or by providing a physical barrier which separates the fill compositions so that they are prevented from mixing. The invention has the advantage that two different formulations can be provided in a single capsule without one of the formulations having an adverse effect on the other.
    Type: Application
    Filed: April 11, 2007
    Publication date: August 30, 2007
    Applicant: PII Drug Delivery, LLC
    Inventors: Stephen Barnwell, Simon Higginbottom, Ian Whelan, Stephen Burns
  • Pharmaceutical formulations
    Publication number: 20050191347
    Abstract: Capsule formulations are provided containing at least two different fill compositions which are prevented from mixing either by providing both of the fill compositions as solids or by providing a physical barrier which separates the fill compositions so that they are prevented from mixing. The invention has the advantage that two different formulations can be provided in a single capsule without one of the formulations having an adverse effect on the other.
    Type: Application
    Filed: August 29, 2003
    Publication date: September 1, 2005
    Applicant: Pll Drug Delivery, LLC
    Inventors: Stephen Barnwell, Simon Higginbottom, Ian Whelan, Stephen Burns
  • Anaesthetic formulations of propofol
    Publication number: 20040253277
    Abstract: Propofol solubilised in aqucous micellar preparations of poloxamers and containing local anaesthctic is associated with reduced levels of pain on injection.
    Type: Application
    Filed: August 12, 2004
    Publication date: December 16, 2004
    Inventors: John Meadows, Simon Higginbottom
  • Pharmaceutical formulations
    Patent number: 6613353
    Abstract: Capsule formulations are provided containing at least two different fill compositions which are prevented from mixing either by providing both of the fill compositions as solids or by providing a physical barrier which separates the fill compositions so that they are prevented from mixing. The invention has the advantage that two different formulations can be provided in a single capsule without one of the formulations having an adverse effect on the other.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 2, 2003
    Assignee: PII Drug Delivery, LLC
    Inventors: Stephen George Barnwell, Simon Higginbottom, Ian Peter Whelan, Stephen John Burns
  • Biphasic capsule formulation
    Patent number: 6153218
    Abstract: Capsule formulations are provided containing at least two different fill compositions which are prevented from mixing either by providing both of the fill compositions as solids or by providing a physical barrier which separates the fill compositions so that they are prevented from mixing. The invention has the advantage that two different formulations can be provided in a single capsule without one of the formulations having an adverse effect on the other.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: November 28, 2000
    Assignee: Provalis UK Limited
    Inventors: Stephen George Barnwell, Simon Higginbottom, Ian Peter Whelan, Stephen John Burns