Patents by Inventor Simon Hoffenberg

Simon Hoffenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LYSIN POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA
    Publication number: 20230050560
    Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.
    Type: Application
    Filed: July 8, 2022
    Publication date: February 16, 2023
    Inventors: Raymond SCHUCH, Simon HOFFENBERG, Michael WITTEKIND
  • Lysin polypeptides active against Gram-negative bacteria
    Patent number: 11413334
    Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: August 16, 2022
    Assignee: CONTRAFECT CORPORATION
    Inventors: Raymond Schuch, Simon Hoffenberg, Michael Wittekind
  • LYSIN POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA
    Publication number: 20200376096
    Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.
    Type: Application
    Filed: July 9, 2020
    Publication date: December 3, 2020
    Inventors: Raymond SCHUCH, Simon HOFFENBERG, Michael WITTEKIND
  • Lysin polypeptides active against Gram-negative bacteria
    Patent number: 10744189
    Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 18, 2020
    Assignee: CONTRAFECT CORPORATION
    Inventors: Raymond Schuch, Simon Hoffenberg, Michael Wittekind
  • LYSIN POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA
    Publication number: 20190070269
    Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 7, 2019
    Inventors: Raymond SCHUCH, Simon HOFFENBERG, Michael WITTEKIND
  • Methods to improve vector expression and genetic stability
    Patent number: 9944935
    Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: April 17, 2018
    Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
    Inventors: Christopher L. Parks, Kevin J. Wright, Maoli Yuan, Christy K. Jurgens, Xinsheng Zhang, Arban Domi, Simon Hoffenberg, Maria J. Chiuchiolo, Svetlana Rabinovich, Aaron J. Wilson, Ivo C. Lorenz
  • HIV-1 envelope glycoprotein
    Patent number: 9738688
    Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: August 22, 2017
    Assignees: INTERNATIONAL AIDS VACCINE INITIATIVE, THE SCRIPPS RESEARCH INSTITUTE, CORNELL UNIVERSITY
    Inventors: Michael Caulfield, Albert Cupo, Hansi Dean, Simon Hoffenberg, C. Richter King, P. J. Klasse, Andre Marozsan, John P. Moore, Rogier W. Sanders, Andrew Ward, Ian Wilson, Jean-Philippe Julien
  • Methods for identifying broadly neutralizing antibodies utilizing recombinant HIV-1 envelope glycoproteins comprising stabilizing mutations
    Patent number: 9562078
    Abstract: The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: February 7, 2017
    Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
    Inventors: Simon Hoffenberg, Christopher L. Parks, Alexei Carpov
  • METHODS TO IMPROVE VECTOR EXPRESSION AND GENETIC STABILITY
    Publication number: 20160222392
    Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 4, 2016
    Inventors: Christopher L. Parks, Kevin J. Wright, Maoli Yuan, Christy K. Jurgens, Xinsheng Zhang, Arban Domi, Simon Hoffenberg, Maria J. Chiuchiolo, Svetlana Rabinovich, Aaron J. Wilson, Ivo C. Lorenz
  • Methods to improve vector expression and genetic stability
    Patent number: 9347065
    Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
    Type: Grant
    Filed: March 10, 2013
    Date of Patent: May 24, 2016
    Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE
    Inventors: Christopher L. Parks, Kevin J. Wright, Maoli Yuan, Christy K. Jurgens, Xinsheng Zhang, Arban Domi, Simon Hoffenberg, Maria J. Chiuchiolo, Svetlana Rabinovich, Aaron J. Wilson, Ivo C. Lorenz
  • METHODS OF IDENTIFYING NOVEL HIV-1 IMMUNOGENS
    Publication number: 20150065381
    Abstract: The present application relates to identifying one or more components of HIV envelope glycoprotein which bind to broadly neutralizing antibodies, which may be utilized as research tools for developing HIV-1 vaccine immunogens, antigens for crystallization and/or for identifying of broad neutralizing antibodies.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 5, 2015
    Inventors: SIMON HOFFENBERG, C. RICHTER KING, CHRISTOS PETROPOULOS, SANJAY K. PHOGAT, DENISE WAGNER, TERRI WRIN
  • NOVEL HIV-1 ENVELOPE GLYCOPROTEIN
    Publication number: 20140212458
    Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron micrsocopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: November 5, 2013
    Publication date: July 31, 2014
    Applicants: INTERNATIONAL AIDS VACCINE INITIATIVE, THE SCRIPPS RESEARCH INSTITUTE, CORNELL CENTER FOR TECHNOLOGY ENTERPRISE AND COMMERCIALIZATION
    Inventors: Michael Caulfield, Albert Cupo, Hansi Dean, Simon Hoffenberg, C. Richter King, P. J. Klasse, Andre Marozsan, John P. Moore, Rogier W. Sanders, Andrew Ward, Ian Wilson, Jean-Philippe Julien
  • HIV-1 ENVELOPE GLYCOPROTEIN
    Publication number: 20140037681
    Abstract: The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: June 27, 2013
    Publication date: February 6, 2014
    Inventors: Simon HOFFENBERG, Chris PARKS, Alexei CARPOV
  • HIV-1 envelope glycoprotein
    Patent number: 8586056
    Abstract: The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: November 19, 2013
    Assignee: International AIDS Vaccine Initiative
    Inventors: Sanjay K. Phogat, Wayne C. Koff, Charles Richter King, Denise Wagner, Simon Hoffenberg
  • METHODS TO IMPROVE VECTOR EXPRESSION AND GENETIC STABILITY
    Publication number: 20130266989
    Abstract: The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
    Type: Application
    Filed: March 10, 2013
    Publication date: October 10, 2013
    Applicant: International AIDS Vaccine Initiative
    Inventors: Christopher L. Parks, Kevin J. Wright, Maoli Yuan, Christy K. Jurgens, Xinsheng Zhang, Arban Domi, Simon Hoffenberg, Maria J. Chiuchiolo, Svetlana Rabinovich, Aaron J. Wilson, Ivo C. Lorenz
  • IMMUNOSELECTION OF RECOMBINANT VESICULAR STOMATITIS VIRUS EXPRESSING HIV-1 PROTEINS BY BROADLY NEUTRALIZING ANTIBODIES
    Publication number: 20130189754
    Abstract: The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: September 12, 2012
    Publication date: July 25, 2013
    Applicant: INTERNATIONAL AIDS VACCINE INITIATIVE
    Inventors: Christopher L. Parks, Christy Jurgens, Perry J. Tiberio, Simon Hoffenberg
  • Novel HIV-1 Envelope Glycoprotein
    Publication number: 20110262488
    Abstract: The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
    Type: Application
    Filed: March 2, 2011
    Publication date: October 27, 2011
    Inventors: Sanjay K. Phogat, Wayne C. Koff, Charles Richter King, Denise Wagner, Simon Hoffenberg
  • Method for removing endotoxins from protein solutions
    Publication number: 20040198957
    Abstract: A method for removing endotoxin contaminants from protein solutions using hydrophobic charge induction chromatography sorbents. The methods comprise adjusting the ph of a protein solution to a pH of from about 8.0 to about 9.0, binding the protein to a hydrophobic charge induction chromatography sorbent; and eluting the protein from the sorbent using an elution buffer having a pH of from about 3.0 about 5.0. The method is particularly useful for removing endotoxin contaminants from antibody compositions.
    Type: Application
    Filed: February 27, 2004
    Publication date: October 7, 2004
    Inventors: Inna Way, Simon Hoffenberg, Taeha An, Jeffrey Su