Abstract: The present invention provides a therapeutic device that comprises of mixture of cells secreting combination of therapeutic proteins, where cells producing therapeutic proteins are sealed in container which enables the exchange of nutrient and therapeutic proteins. The cells inside the therapeutic device produce and secrete certain amounts of therapeutic proteins. Cells are prepared by introducing genes encoding therapeutic proteins under the control of a constitutive or inducible promoter. The combination and concentration of therapeutic proteins is defined by the ratio of cells secreting different therapeutic proteins and/or by the gene expression ratio of the therapeutic proteins in the cells incorporated into the semi-permeable container. The therapeutic device can be used for treatments of various diseases and injuries for instance enhancement of wound healing and angiogenesis.

Abstract: A mouse cDNA is illustrated by FIG. 3 (SEQ ID NO:1) which, when knocked out or prevented from expression, results in high growth. This mouse cDNA is highly homologous to genes of other species, such as human and cattle.

Abstract: A method of controlling the differentiation of a cell is provided which comprises modulation of the expression of the gene Raidd in the cell. The method provides a means for preparing or enriching a population of stem cells through modulation of Raidd expression.

Abstract: This invention pertains to the discovery of a gene, reduced expression of which results in a high growth (hg) phenotype. This invention pertains to knockout animals displaying such a high growth phenotype and to methods of screening for agents that modulate a high growth phenotype.