Abstract: A mixed traffic flow-oriented vehicle eco-driving control method and an electronic device are provided. The method includes: calculating a gathering wave speed and a dissipation wave speed at an intersection, and obtaining a farthest queue point position of a connected and autonomous vehicle at a downstream intersection and a time, acquiring predicted trajectories of the manual-driving vehicle; constructing and solving an optimal ecological reference trajectory planning model of the connected and autonomous vehicle, obtaining an acceleration curve of the connected and autonomous vehicle, and acquiring an ecological reference trajectory of the connected and autonomous vehicle; and setting a risk factor based on the predicted trajectories of the manual-driving vehicles, constructing a tracking target based on the risk factor and the ecological reference trajectory, using a model predictive control for solving, and obtaining a control input of the connected and autonomous vehicle.