Patents by Inventor Simon Hufton

Simon Hufton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Influenza virus antibody compositions
    Patent number: 9771415
    Abstract: The present invention relates to unique CDR3 amino acid sequences, and to antibodies comprising said sequences. Also provided are therapeutic applications of said antibodies for use in treating or preventing influenza infection, diagnostic applications of said antibodies for use in detecting influenza virus, potency testing of influenza virus vaccines, and screening applications of said antibodies for use in designing a universal influenza vaccine.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: September 26, 2017
    Assignee: The Secretary of State for Health
    Inventor: Simon Hufton
  • INFLUENZA VIRUS ANTIBODY COMPOSITIONS
    Publication number: 20140302063
    Abstract: The present invention relates to unique CDR3 amino acid sequences, and to antibodies comprising said sequences. Also provided are therapeutic applications of said antibodies for use in treating or preventing influenza infection, diagnostic applications of said antibodies for use in detecting influenza virus, potency testing of influenza virus vaccines, and screening applications of said antibodies for use in designing a universal influenza vaccine.
    Type: Application
    Filed: September 3, 2012
    Publication date: October 9, 2014
    Applicant: The Secretary of State for Health
    Inventor: Simon Hufton
  • Methods of using an antibody that binds to apolipoprotein e
    Patent number: 8058016
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 15, 2011
    Assignees: Astrazeneca AB, Dyax Corporation
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • Antibodies
    Publication number: 20100061993
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Application
    Filed: September 8, 2009
    Publication date: March 11, 2010
    Applicants: ASTRAZENECA AB, DYAX CORPORATION
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • antibodies binding to a C-terminal fragment of apoliopoprotein E
    Patent number: 7612179
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: November 3, 2009
    Assignees: Astrazeneca AB, Dyax Corporation
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • Antibodies binding to a c-terminal fragment of apoliopoprotein e
    Publication number: 20070104715
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Application
    Filed: November 26, 2004
    Publication date: May 10, 2007
    Applicants: ASTRAZENECA AB, DYAX CORP.
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, Rene Hoet, Henricus Hoogenboom, Simon Hufton, Christian Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • Tie complex binding proteins
    Publication number: 20060057138
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
    Type: Application
    Filed: August 9, 2005
    Publication date: March 16, 2006
    Inventors: Clive Wood, Daniel Dransfield, Henk Pieters, Rene Hoet, Simon Hufton
  • Tie complex binding proteins
    Publication number: 20060024297
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
    Type: Application
    Filed: February 2, 2005
    Publication date: February 2, 2006
    Inventors: Clive Wood, Daniel Dransfield, Henk Pieters, Rene Hoet, Simon Hufton
  • Tie1-binding ligands
    Publication number: 20050136053
    Abstract: Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.
    Type: Application
    Filed: August 12, 2004
    Publication date: June 23, 2005
    Inventors: Simon Hufton, Rene Hoet, Henk Pieters