Patents by Inventor Simon J. Prosser
Simon J. Prosser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6956207Abstract: A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis.Type: GrantFiled: April 1, 2003Date of Patent: October 18, 2005Assignee: Advion BioScience, Inc.Inventors: Thomas N. Corso, Gary A. Schultz, Simon J. Prosser, Xian Huang
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Patent number: 6814870Abstract: A microchip-based electrospray ionization device and column with affinity adsorbents is disclosed. The invention includes a microchip array and a capillary tube or alone or attached in combination. At least a portion of the device or column has immobilized affinity adsorbents. Methods for using the device are provided as well for affinity capture of biomolecules to meet the needs for the modem life sciences such as proteomics and drug discover.Type: GrantFiled: September 9, 2003Date of Patent: November 9, 2004Assignee: Advion BioSciences, Inc.Inventors: Sheng Zhang, Xian Huang, Thomas N. Corso, Gary A. Schultz, Simon J. Prosser
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Patent number: 6811689Abstract: A microchip-based electrospray ionization device and column with affinity adsorbents is disclosed. The invention includes a microchip array and a capillary tube or alone or attached in combination. At least a portion of the device or column has immobilized affinity adsorbents. Methods for using the device are provided as well for affinity capture of biomolecules to meet the needs for the modern life sciences such as proteomics and drug discover.Type: GrantFiled: September 9, 2003Date of Patent: November 2, 2004Assignee: Advion BioSciences, Inc.Inventors: Sheng Zhang, Xian Huang, Thomas N. Corso, Gary A. Schultz, Simon J. Prosser
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Patent number: 6723985Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream.Type: GrantFiled: January 23, 2003Date of Patent: April 20, 2004Assignee: Advion BioSciences, Inc.Inventors: Gary A. Schultz, Thomas N. Corso, Simon J. Prosser
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Publication number: 20030201390Abstract: A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis.Type: ApplicationFiled: April 1, 2003Publication date: October 30, 2003Inventors: Thomas N. Corso, Gary A. Schultz, Simon J. Prosser, Xian Huang
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Patent number: 6627882Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream.Type: GrantFiled: December 22, 2000Date of Patent: September 30, 2003Assignee: Advion Biosciences, Inc.Inventors: Gary A. Schultz, Thomas N. Corso, Simon J. Prosser
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Publication number: 20030143493Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream.Type: ApplicationFiled: January 23, 2003Publication date: July 31, 2003Inventors: Gary A. Schultz, Thomas N. Corso, Simon J. Prosser
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Patent number: 6596988Abstract: A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis.Type: GrantFiled: January 18, 2001Date of Patent: July 22, 2003Assignee: Advion BioSciences, Inc.Inventors: Thomas N. Corso, Gary A. Schultz, Simon J. Prosser, Xian Huang
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Publication number: 20030087454Abstract: A disposable tube includes an inlet end and an outlet end, wherein the inlet end of a first tube is self-locking, self-aligning, self-mating, self-sealing and adapted to detachably engage an outlet end of a second tube. The tube may be filled with separation material. The tubes may be used for micro fluidic separation and fluid transfer. Also included is a tube array having a plurality of tube holders adjacent to one another. Each tube holder has a passageway configured to receive a tube. Each passageway constrains the movement of a tube in the array: allowing free movement of the tube along the tube axis, while allowing limited sideways movement of the tube, so that the tube is held in alignment with a corresponding input port of, for example, a sample transfer device.Type: ApplicationFiled: October 28, 2002Publication date: May 8, 2003Inventors: Gary A. Schultz, Thomas N. Corso, Gary S. Sheldon, David R. Jung, Christopher G. Alpha, Geoffrey S. Rule, Xian Huang, Simon J. Prosser
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Publication number: 20020110902Abstract: A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler.Type: ApplicationFiled: January 28, 2002Publication date: August 15, 2002Inventors: Simon J. Prosser, Geoffrey S. Rule, Gary A. Schultz, Thomas N. Corso
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Publication number: 20020000517Abstract: A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid for analysis.Type: ApplicationFiled: January 18, 2001Publication date: January 3, 2002Inventors: Thomas N. Corso, Gary A. Schultz, Simon J. Prosser, Xian Huang
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Publication number: 20020000516Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream.Type: ApplicationFiled: December 22, 2000Publication date: January 3, 2002Inventors: Gary A. Schultz, Thomas N. Corso, Simon J. Prosser