Abstract: This invention relates generally to compositions for making and administering anellovectors and uses thereof.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: A sensor module assembly for a respiratory therapy apparatus may be configured for a seal-based securement within a respiratory therapy device that includes a separable pneumatic block to make assembly or replacement more efficient. The sensor module assembly may include a flow manifold. The flow manifold may have an inlet and an outlet and a main pneumatic path between the inlet and the outlet. The assembly may have a sensor module with sensor(s) on a printed circuit board. The sensor module may be pneumatically and fixedly coupled to the flow manifold. The inlet of the flow manifold may be configured for removable coupling with an outlet of the pneumatic block assembly. Moreover, the outlet of the flow manifold may be configured for removable coupling with a pneumatic path of a housing panel of the respiratory therapy apparatus. The pneumatic path is adapted for supplying breathable gas to a patient interface.

Abstract: According to one aspect, an electric toothbrush may include a handle, a brush head, a rechargeable battery, an electric motor, and a pair of electrical contacts. The handle may have a first end region and a second end region defining a longitudinal axis therebetween, the handle defining a volume from the first end region to the second end region. The brush head may include bristles, the brush head releasably securable to the first end region of the handle. The rechargeable battery may be in the volume. The electric motor may be at least partially disposed in the volume, the electric motor in electrical communication with the rechargeable battery, the electric motor in mechanical communication with the brush head. The pair of electrical contacts may be in electrical communication with the rechargeable battery, and the pair of electrical contacts axially and radially spaced from one another, relative to the longitudinal axis.

Abstract: A breathing assistance apparatus and method of controlling a breathing assistance apparatus is disclosed. Particularly, the breathing assistance apparatus is controlled such that it has a drying cycle to enable drying of the tubing that supplies gases to a user and prevent the harbouring of pathogens within the tube. The drying cycle is preferably operated automatically by internal controllers in the apparatus. However, it may be manually activated by pressing a button on the apparatus. The drying cycle is preferably activated at the end of a user's treatment session.

Abstract: A retractable fuselage mounted landing gear assembly is disclosed. The landing gear assembly includes a main strut, a drag stay and a landing gear main fitting. A first end of the drag stay is attached to the main strut and a second end of the drag stay is connected to the fuselage. A first end of the landing main fitting is attached to the main strut and a second end of the main fitting is connected to the fuselage. When the landing gear is extended, substantially all the landing gear loads are transferred from the landing gear to the fuselage via one or more of the drag stay and the main fitting.

Abstract: A coating thickness measuring instrument comprising: a magnetic induction probe comprising at least one drive coil and at least one pick-up coil; a driver for driving an alternating current in the or each drive coil; and a detector for detecting the output of the or each pick-up coil; and a processor configured to: apply a transfer function to the detector output to produce an output which corresponds to a measured coating thickness; and, scale both the drive current and detector output simultaneously in response to the output. The scaling may be changed in a step-wise manner. The scaling applied to the drive current may be inversely proportional to the scaling applied to the detector output. The scaling may be defined by a first and second scaling factor, stored as a pair. The instrument may store two or more pairs of scaling factors and select a pair in response to the measured coating thickness.

Abstract: A nerve regeneration device comprising a bioresorbable conduit and a matrix contained therein having elongate pores aligned with the longitudinal axis of the conduit. The matrix comprises collagen, fibronectin, laminin-1, and laminin-2, wherein the amount, by weight, of laminin-1 or laminin-2 is greater than the amount of fibronectin in the matrix.

Abstract: An implement for use with an excavator includes a lightweight housing, a first coupling feature, a ground penetrating radar antenna, a controller, a wireless communication circuit and a rotation unit. The lightweight housing has an upper surface, a lower surface and a cavity. The first coupling feature is located on the upper surface and cooperates with a second coupling feature on an excavator arm. The ground penetrating radar antenna is mounted near the lower surface. The controller is mounted within the cavity and provides outgoing signals to the radar antenna, receives incoming signals from the radar antenna and interprets the incoming signals so as to provide implement output information. The wireless communication circuit is mounted within the cavity and transmits the implement output information. The rotation unit is mounted within the cavity and rotates the housing vis-à-vis the excavator arm.

Abstract: An interactive toy comprising a function device for performing user-perceptible, controllable functions. The interactive toy also includes a rechargeable power source and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The interactive toy is adapted to determine a charging rate at respective positions relative to the charging device and to generate a user-perceptible output indicative of the determined charging rate.

Abstract: An input device includes a control surface for a color correction system. The control surface includes a housing with an upwardly facing control panel. The control panel has a proximal edge which is nearest a user and a distal edge that is furthest from a user in normal use. The control panel includes a plurality of controls. The plurality of controls includes: a plurality of trackballs, wherein each trackball comprises a ball and a control ring, said ball cooperating with at least one encoder to generate a multi-dimensional control signal based on motion of the ball, and said control ring cooperating with at least one encoder to generate a one dimensional control signal based on the rotational motion of the ring, wherein the ball of said trackball is mounted concentrically with said control ring; a plurality of control buttons; and a plurality of knobs coupled to respective rotary encoders.

Abstract: Disclosed are various examples for an application settings module that provides uniform access to diverse types of data, such as mobile device settings. A client device, such as a mobile device, can be configured through execution of program instructions to access a schema file comprising a definition of a plurality of keypaths, where individual ones of the plurality of keypaths uniquely correspond to one of a plurality of device settings and the keypaths are defined in the schema file in association with a plurality of methods. The client device can identify a function invoked using one of the keypaths to read or write a corresponding one of the device settings, whether stored locally or remote, and, in response to the function being invoked, execute a portion of the methods corresponding to the one of the keypaths in the schema file and return a result to a requesting process.

Abstract: Among other things, advertisements are received for brands or products of brands. Criteria for placement of the advertisements are received at online retail sites. The online retail sites are controlled independently from one another. Inventory data for the products at the online retail sites is received and stored. Data about propensities of the consumers to favor one or more of the brands or one or more products of the brands, from activities of consumers on the online retail sites, is stored. Activity data about current activities of the consumers on the online retail sites is received. One or more of the advertisements are placed on pages served to the online retail sites based on the placement data, the inventory data, the propensity data, and the activity data. Conversion data is received indicating that consumers engaged in conversion events with respect to products associated with the brands or products of brands being advertised.

Abstract: A machine-learning accelerator system, comprising: a plurality of controllers each configured to traverse a feature map with n-dimensions according to instructions that specify, for each of the n-dimensions, a respective traversal size, wherein each controller comprises: a counter stack comprising counters each associated with a respective dimension of the n-dimensions of the feature map, wherein each counter is configured to increment a respective count from a respective initial value to the respective traversal size associated with the respective dimension associated with that counter; a plurality of address generators each configured to use the respective counts of the counters to generate at least one memory address at which a portion of the feature map is stored; and a dependency controller computing module configured to (1) track conditional statuses for incrementing the counters and (2) allow or disallow each of the counters to increment based on the conditional statuses.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for transaction management. One of the methods includes, for a first transaction from a plurality of transactions, in response to determining that the first transaction for a corresponding user account at a first entity satisfies the threshold criteria for a corresponding second entity, accessing account data for the corresponding user account, first data for the first entity, and second data for the second entity to complete the first transaction. For a second transaction, in response to determining that the second transaction for a corresponding user account at the first entity does not satisfy the threshold criteria for the corresponding second entity, a determination is made to not access second data for the corresponding second entity, and account data is accessed for the corresponding user account and the first data for the first entity to complete the second transaction.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.