Abstract: The present invention provides a compound of Formula I: Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the compound and to methods of using the compound to treat physiological disorders.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for predicting properties of molecules based on the structure and composition of the molecules. In one aspect, a method comprises receiving molecule data characterizing a molecule and processing a model input based on the molecule data characterizing the molecule using a property prediction machine learning model comprising an ordered sequence of processing layers to generate, for each of a set of molecule properties, a respective value for the molecule property wherein: each processing layer is associated with a respective proper subset of the set of molecule properties; and each processing layer after the first in the sequence generates predicted molecule property values based on: (i) the model input to the property prediction machine learning model, and (ii) predicted molecule property values generated by one or more preceding processing layers in the sequence of processing layers.

Abstract: The present invention provides a compound of Formula I: Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the compound and to methods of using the compound to treat physiological disorders.

Abstract: The present invention provides compounds of Formula II or a pharmaceutically acceptable salts thereof, useful as a CGRP receptor antagonist.

Abstract: The present invention provides compounds of Formula II or a pharmaceutically acceptable salts thereof, useful as a CGRP receptor antagonist.

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof, that are inhibitors of BACE.

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides certain 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds, particularly compounds of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat Parkinsons disease Formula (I).

Abstract: The invention provides certain 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds, particularly compounds of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat Parkinsons disease Formula (I).

Abstract: Compounds of the formula I or a pharmaceutically acceptable salt thereof: processes for their preparation, pharmaceutical compositions which contain them and their uses in therapy.

Abstract: Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents.

Abstract: An electrochemical ion exchange cell comprises a metal carbollide as ion exchange material. The carbollide is preferably a polynuclear cobalt dicarbollide and is typically substituted by chlorine. Also novel are polynuclear metal carbollides comprising a substituted carbollide cage, as well as metal carbollides comprising a carbollide cage substituted by a moiety having a —COOH or —SH group.