Abstract: Methods for reducing the progression of ER+breast cancer in a patient are provided, the methods comprising administering to the patient an effective amount of lasofoxifene or a pharmaceutically acceptable salt thereof and an effective amount of a CDK4/6 inhibitor (CDK4/6i), wherein the breast cancer: (i) is estrogen receptor positive (ER+); (ii) has at least one gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene; and (iii) has progressed during prior CDK4/6 inhibitor therapy and/or has an oncogenic mutation in a gene other than ESR1.

Abstract: Methods for reducing the progression of ER+ breast cancer in a patient are provided, the methods comprising administering to the patient an effective amount of lasofoxifene or a pharmaceutically acceptable salt thereof and an effective amount of a CDK4/6 inhibitor (CDK4/6i), wherein the breast cancer: (i) is estrogen receptor positive (ER+); (ii) has at least one gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene; and (iii) has progressed during prior CDK4/6 inhibitor therapy and/or has an oncogenic mutation in a gene other than ESR1.

Abstract: The present invention is directed to systems and methods for acquiring media of the same event from multiple devices. The systems and methods enable wireless communication, specifically over a Bluetooth Low Energy (BLE) wireless personal area network, between multiple media devices, such as personal or consumer devices (i.e., consumer smartphones, tablets, wearable devices, including action cameras, or other computing devices capable to capturing media content in the form of image, video, or audio data) at an event. The systems and methods further enable synchronization, via a specialized timing protocol, between the multiple media devices, over the BLE network, including synchronization of the media content captured by each of the media devices at the event. The present invention further includes an accessory device configured to provide for expansion of communication and synchronization of media devices, specifically bridging a short range BLE network with a long range RF network.

Abstract: The present invention is directed to systems and methods for acquiring media of the same event from multiple devices. The systems and methods enable wireless communication, specifically over a Bluetooth Low Energy (BLE) wireless personal area network, between multiple media devices, such as personal or consumer devices (i.e., consumer smartphones, tablets, wearable devices, including action cameras, or other computing devices capable to capturing media content in the form of image, video, or audio data) at an event. The systems and methods further enable synchronization, via a specialized timing protocol, between the multiple media devices, over the BLE network, including synchronization of the media content captured by each of the media devices at the event. The present invention further includes an accessory device configured to provide for expansion of communication and synchronization of media devices, specifically bridging a short range BLE network with a long range RF network.

Abstract: This invention relates to the use bazedoxifene (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol) in the treatment or inhibition of osteoporosis and osteopenia related to aromatase inhibitor therapy.