Abstract: A system and method for performing diagnostics on a computer system having a plurality of physical hardware devices includes associating a logical device with a physical hardware device of the computer system. The logical device is provided with a programmatic interface that abstractly reproduces a functionality of the physical hardware device associated with the logical device and insulates the logical device from device-specific particulars needed to communicate with the physical hardware device. The logical device is associated with a translator that is capable of communicating with the physical hardware device associated with the logical device using the device-specific particulars needed to communicate with that physical hardware device.

Abstract: Sustained release formulations comprising molecules modified so as to have a reduced clearance is provided.

Abstract: The present invention provides methods and compositions for treating bleeding episodes. The methods are carried out by administering to a patient in need thereof a preparation comprising a factor XI polypeptide, in an amount effective for such treatment. The methods of the invention result in one or more of: reduced clotting time; enhancement of hemostasis; increase in clot lysis time; increase in clot strength; and/or increase in overall clot quality (OCQ) in said patient.