Abstract: A method and system for determining a route map and a route for a vehicle. Generating the route map comprises obtaining historical data comprising a plurality of data points for each of a plurality of vehicles from storage and determining a plurality of nodes each representing a subset of the data points. The historical data is applied to the plurality of nodes to determine the closest node for each vehicle. The nodes are ordered for each of the plurality of vehicles in the historical data by time; and a directed edge is generated between a first and second node of the plurality of ordered nodes, based on when the historical data indicates that a given vehicle has transited from the first node and the second node. A route is determined for the vehicle based on the generated route map and outputted route to a control system.

Abstract: A system and method for performing diagnostics on a computer system having a plurality of physical hardware devices includes associating a logical device with a physical hardware device of the computer system. The logical device is provided with a programmatic interface that abstractly reproduces a functionality of the physical hardware device associated with the logical device and insulates the logical device from device-specific particulars needed to communicate with the physical hardware device. The logical device is associated with a translator that is capable of communicating with the physical hardware device associated with the logical device using the device-specific particulars needed to communicate with that physical hardware device.

Abstract: Sustained release formulations comprising molecules modified so as to have a reduced clearance is provided.

Abstract: The present invention provides methods and compositions for treating bleeding episodes. The methods are carried out by administering to a patient in need thereof a preparation comprising a factor XI polypeptide, in an amount effective for such treatment. The methods of the invention result in one or more of: reduced clotting time; enhancement of hemostasis; increase in clot lysis time; increase in clot strength; and/or increase in overall clot quality (OCQ) in said patient.