Abstract: A method for assessing a risk associated with a skin abnormality is disclosed. The method involves using a skin abnormality detection model to analyze a current image dataset captured by a skin inspection device to identify a current instance of a feature of interest and determine an associated risk level. The model is trained using a process that generates enriched training data. The process comprises receiving user-generated annotations for a feature of interest across a series of historical image datasets captured over time. These historical datasets are aligned using an image registration process to establish a consistent anatomical location for the feature. A set of training data records is then generated, with each record comprising an annotation, a set of image acquisition parameters used for the corresponding image, and data defining the consistent anatomical location. The skin abnormality detection model is subsequently trained using this set of training data records.

Abstract: A method for analyzing a feature of interest using a skin inspection system is disclosed. The method comprises generating a first output from a first machine learning model, which analyzes a current image dataset from a skin inspection device to determine a detected state of the feature on a user's skin. A second machine learning model generates a second output comprising a predicted state of the feature, based on historical data for that feature. A processor compares the first output (the detected state) with the second output (the predicted state) to determine a deviation. Finally, the determined deviation is classified into one of a plurality of predefined clinical risk categories.

Abstract: A method for operating a skin inspection device is disclosed. The method provides for an adaptive image acquisition process to improve the visibility of detected features. The method comprises capturing a first image of an inspection area and analyzing the first image with a processor to identify a feature of interest. Based on one or more characteristics of the identified feature, the processor determines a set of adjusted image acquisition parameters. A second, feature inspection image is then captured of at least a portion of the inspection area using these adjusted parameters. The adjusted image acquisition parameters are specifically configured to optimize the visibility of the identified feature of interest in the second image, thereby enabling a more detailed and accurate analysis.

Abstract: A skin inspection device for identifying abnormalities is described. The device comprises a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; one or more image capture devices having a wide angle lens for capturing an image of the TLC formations and an area of skin of a target located in the inspection area; at least some of the TLC formations have a warped shape while other TLC formations have a non-warped shape; wherein the warped shaped TLC formations and the non-warped TLC formations define a pattern such that when viewed through the wide angle lens both the the warped shaped TLC formations and the non-warped TLC formations appear non-warped.

Abstract: A skin inspection device for identifying abnormalities. The device comprises a transparent panel having an inspection area. An array of temperature sensors are provided on the transparent panel to record the temperature of an area of skin of a target. One or more image capture devices are provided for capturing an image of the area of skin of a target located in the inspection area. The captured image and recorded temperature being analysed to identify abnormalities in the area of skin of the target. A processor is operably coupled to the one or more image capture devices and the array of temperature sensors for controlling operations thereof. The processor is operable to generate indicia indicative of the emergence of ulcers and/or other skin abnormalities.

Abstract: A panel for a skin inspection device is described. The panel comprises a substrate; an array of temperature sensors; an interlayer comprising a material for thermally insulating the temperature sensors from the substrate.

Abstract: A skin inspection device for identifying abnormalities; the device comprising: a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; and one or more image capture devices for capturing a colour image of the TLC formations and an area of skin of a target located in the inspection area; the captured colour image being analysed to identify abnormalities in the area of skin.

Abstract: A skin inspection device for identifying abnormalities is described. The device comprises a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; one or more image capture devices having a wide angle lens for capturing an image of the TLC formations and an area of skin of a target located in the inspection area; at least some of the TLC formations have a warped shape while other TLC formations have a non-warped shape; wherein the warped shaped TLC formations and the non-warped TLC formations define a pattern such that when viewed through the wide angle lens both the warped shaped TLC formations and the non-warped TLC formations appear non-warped.

Abstract: A skin inspection device for identifying abnormalities. The device comprises a transparent panel having an inspection area. An array of temperature sensors are provided on the transparent panel to record the temperature of an area of skin of a target. One or more image capture devices are provided for capturing an image of the area of skin of a target located in the inspection area. The captured image and recorded temperature being analysed to identify abnormalities in the area of skin of the target. A processor is operably coupled to the one or more image capture devices and the array of temperature sensors for controlling operations thereof. The processor is operable to generate indicia indicative of the emergence of ulcers and/or other skin abnormalities.

Abstract: A skin inspection device for identifying abnormalities; the device comprising: a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; and one or more image capture devices for capturing a colour image of the TLC formations and an area of skin of a target located in the inspection area; the captured colour image being analysed to identify abnormalities in the area of skin.

Abstract: A skin inspection device for identifying abnormalities is described. The device comprises a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; one or more image capture devices having a wide angle lens for capturing an image of the TLC formations and an area of skin of a target located in the inspection area; at least some of the TLC formations have a warped shape while other TLC formations have a non-warped shape; wherein the warped shaped TLC formations and the non-warped TLC formations define a pattern such that when viewed through the wide angle lens both the warped shaped TLC formations and the non-warped TLC formations appear non-warped.

Abstract: Transcatheter guidewire delivery systems, catheter assemblies and associated methods for percutaneous guidewire delivery across heart valves are disclosed herein. A catheter assembly configured in accordance herewith includes an elongated tubular component and an alignment assembly at a distal portion of the tubular component and which is adapted to be located at a target location adjacent a heart valve of a patient. In one embodiment, the alignment assembly deploys to a shape set loop configuration with a side port in an open configuration positioned to allow advancement of a guidewire to exit the catheter in an aligned path with a leaflet coaptation region of the heart valve. In another embodiment, the alignment assembly has a plurality of spaced apart side ports that a guidewire may advance therethrough and toward the heart valve. In some embodiments, a wire guide is used to align the guidewire with a selected side port.

Abstract: Transcatheter guidewire delivery systems, catheter assemblies and associated methods for percutaneous guidewire delivery across heart valves are disclosed herein. A catheter assembly configured in accordance herewith includes an elongated tubular component and an alignment assembly at a distal portion of the tubular component and which is adapted to be located at a target location adjacent a heart valve of a patient. In one embodiment, the alignment assembly deploys to a shape set loop configuration with a side port in an open configuration positioned to allow advancement of a guidewire to exit the catheter in an aligned path with a leaflet coaptation region of the heart valve. In another embodiment, the alignment assembly has a plurality of spaced apart side ports that a guidewire may advance therethrough and toward the heart valve. In some embodiments, a wire guide is used to align the guidewire with a selected side port.

Abstract: Transcatheter guidewire delivery systems, catheter assemblies and associated methods for percutaneous guidewire delivery across heart valves are disclosed herein. A catheter assembly configured in accordance herewith includes an elongated tubular component and an alignment assembly at a distal portion of the tubular component and which is adapted to be located at a target location adjacent a heart valve of a patient. In one embodiment, the alignment assembly deploys to a shape set loop configuration with a side port in an open configuration positioned to allow advancement of a guidewire to exit the catheter in an aligned path with a leaflet coaptation region of the heart valve. In another embodiment, the alignment assembly has a plurality of spaced apart side ports that a guidewire may advance therethrough and toward the heart valve. In some embodiments, a wire guide is used to align the guidewire with a selected side port.

Abstract: Catheters including elements configured to deliver energy to nerves at or near a treatment location within a body lumen. A treatment assembly is transformable between a low-profile delivery configuration wherein a pair of electrodes are in a staggered arrangement relative to each other along the longitudinal axis, and an expanded deployed configuration wherein the pair of electrodes is aligned along an electrode axis that is orthogonal relative to the longitudinal axis.

Abstract: A skin inspection device for identifying abnormalities; the device comprising: a transparent panel having an inspection area; an array of thermochromic liquid crystal (TLC) formations provided on the transparent panel which are operable to change colour in response to a change of temperature; and one or more image capture devices for capturing a colour image of the TLC formations and an area of skin of a target located in the inspection area; the captured colour image being analysed to identify abnormalities in the area of skin.

Abstract: A skin inspection device for identifying abnormalities. The device comprises a transparent panel having an inspection area. An array of temperature sensors are provided on the transparent panel to record the temperature of an area of skin of a target. One or more image capture devices are provided for capturing an image of the area of skin of a target located in the inspection area. The captured image and recorded temperature being analysed to identify abnormalities in the area of skin of the target. A processor is operably coupled to the one or more image capture devices and the array of temperature sensors for controlling operations thereof. The processor is operable to generate indicia indicative of the emergence of ulcers and/or other skin abnormalities.

Abstract: Transcatheter guidewire delivery systems, catheter assemblies and associated methods for percutaneous guidewire delivery across heart valves are disclosed herein. A catheter assembly configured in accordance herewith includes an elongated tubular component and an alignment assembly at a distal portion of the tubular component and which is adapted to be located at a target location adjacent a heart valve of a patient. In one embodiment, the alignment assembly deploys to a shape set loop configuration with a side port in an open configuration positioned to allow advancement of a guidewire to exit the catheter in an aligned path with a leaflet coaptation region of the heart valve. In another embodiment, the alignment assembly has a plurality of spaced apart side ports that a guidewire may advance therethrough and toward the heart valve. In some embodiments, a wire guide is used to align the guidewire with a selected side port.

Abstract: Catheters including elements configured to deliver energy to nerves at or near a treatment location within a body lumen. A treatment assembly is transformable between a low-profile delivery configuration wherein a pair of electrodes are in a staggered arrangement relative to each other along the longitudinal axis, and an expanded deployed configuration wherein the pair of electrodes is aligned along an electrode axis that is orthogonal relative to the longitudinal axis.

Abstract: Catheters including elements configured to deliver energy to nerves at or near a treatment location within a body lumen. A treatment assembly is transformable between a low-profile delivery configuration wherein a pair of electrodes are in a staggered arrangement relative to each other along the longitudinal axis, and an expanded deployed configuration wherein the pair of electrodes is aligned along an electrode axis that is orthogonal relative to the longitudinal axis.