Patents by Inventor Simon Krah

Simon Krah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NKP30 BINDERS
    Publication number: 20230287082
    Abstract: B7-H6-based compounds disclosed herein have favorable characteristics. Pharmaceutical compositions containing such a compound, the use of such compounds, and treatment with such pharmaceutical compositions are also disclosed. Methods for preparing a compound with an increased affinity for NKp30 are provided.
    Type: Application
    Filed: August 31, 2021
    Publication date: September 14, 2023
    Applicant: Merck Patent GmbH
    Inventors: Stefan Zielonka, Lars Toleikis, Simon Krah, Lukas Pekar
  • Methods for non-covalent Fc-domain-containing protein display on the surface of cells and methods of screening thereof
    Patent number: 10676733
    Abstract: The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such as antibodies. The inventive method may be used to screen and select proteins of interest of a desired phenotype. The present invention further discloses polynucleotides and proteins and methods of producing the same, which may be used in carrying out the inventive method.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: June 9, 2020
    Assignee: Merck Patent GmbH
    Inventors: Laura Rhiel, Stefan Becker, Ralf Guenther, Bjoern Hock, Daniel Helman, Mira Toister-Achituv, Simon Krah
  • ANTI-C-MET ANTIBODIES AND ANTIBODY DRUG CONJUGATES THEREOF FOR EFFICIENT TUMOR INHIBITION
    Publication number: 20190248907
    Abstract: The present invention provides antibodies and heterodimeric immunoglobulin molecules, which bind cMET with high affinity and can be used to target cMET expressing tumor cells. The present invention also discloses methods of generating anti-cMET antibody drug conjugates using the inventive antibodies or heterodimeric immunoglobulin molecules as disclosed herein.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Achim DOERNER, Lars TOLEIKIS, Birgit PIATER, Laura RHIEL, Christine KNUEHL, Carolin SELLMANN, Simon KRAH
  • METHODS FOR NON-COVALENT FC-DOMAIN-CONTAINING PROTEIN DISPLAY ON THE SURFACE OF CELLS AND METHODS OF SCREENING THEREOF
    Publication number: 20180298374
    Abstract: The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such as antibodies. The inventive method may be used to screen and select proteins of interest of a desired phenotype. The present invention further discloses polynucleotides and proteins and methods of producing the same, which may be used in carrying out the inventive method.
    Type: Application
    Filed: October 27, 2015
    Publication date: October 18, 2018
    Applicant: Merck Patent GmbH
    Inventors: Laura Rhiel, Stefan Becker, Ralf Guenther, Bjoern Hock, Daniel Helman, Mira Toister-Achituv, Simon Krah