Abstract: Provided are compounds having Formula VIIIa-1: wherein Z, X5, R2, R2a and R10 are as defined herein. Compounds of Formula VIIIa-1 can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.

Abstract: An incinerator (20) for disposing of boil-off gas on an LNG carrier comprises a combustion section (40) wherein the boil-off gas admitted at (42) is burned in the presence of combustion air admitted at (44), producing a flame (46) and combustion products (C). Dilution air (A) is delivered into the combustion section (40) and mixed with the combustion products (C) to produce a diluted mixture (M). The combustion section (40) has an inner wall (48) and an outer wall (50) together defining a first passage (52) through which the dilution air (A) is passed before being mixed with the combustion products (C), whereby the dilution air A cools the combustion section (40). The dilution air A in the first passage (52) also provides a thermally insulting layer limiting radial heat transmission from the combustion section (40). A proportion (AP) of the dilution air is mixed directly with the combustion products (C).

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

Abstract: A compound of formula (I): Or its salts or pharmaceutically acceptable derivatives thereof wherein: A represents a chemical moiety with the general formula (II): X and Y are independently selected from a group consisting of CH2, CH(R5) or C(R5)(R6); R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 R4 R5 R6 R7 and R8 are as defined herein, n=0, 1, 2 or 3; o=0, 1 or 2, with the proviso that when o=0, then n is 1, 2 or 3 and when o=1, then n is 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. These compounds are useful in the treatment of various disorders including arrhythmia.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: A compound of formula (I) Or its salts or pharmaceutically acceptable derivatives thereof wherein; A represents a chemical moiety with the general formula (II): X is selected from a group consisting of CH2, C(?O), CH(R5), C(R5)(R6) or C(R5)(R6)CH2; R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 R4 R5 R6 R7 and R8 are as defined herein; and n=1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. The compounds are useful in treating various conditions including arrhythmia.

Abstract: Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ib-1: wherein Z, X1, X2, X5, R2b and R10 are as defined herein. Compounds of Formula Ib-1 can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.

Abstract: The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, R4, R5, X1, and j are defined herein. The compounds are useful as potassium ion channel inhibitors.

Abstract: A paint removal system is disclosed which comprises an environmentally safe paint stripping composition of which the primary constituent is benzyl alcohol, and which is applied to a substrate of one or more layers of paint to be removed from a surface. An impermeable biodegradable membrane is used in conjunction therewith, whereby the membrane is applied as a cover over the applied paint stripper to assist in the penetration of the paint stripping compound into the layers of paint and to assist in subsequent removal of the released paint and used stripper.

Abstract: The loading of crude oil into a storage tank (12) at A causes vent gas comprising a. mixture of VOC and inert gas to be vented from the tank (12) at C. The vent gas is compressed and delivered at D to a burner (32) of a boiler (34). The burner also receives, at F, a supply of oil (14) as a support fuel to provide stable combustion, the supply of oil (14) being adjusted automatically according to the Wobbe Index and flow rate of the vent gas. Steam generated in the boiler (34) from the burning of the fuels is used to heat the oil (14), to counter waxiness, or for other purposes.

Abstract: The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-tetrahydropyran-4-yloxyquinazoline (the active entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containing such crystalline forms.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: A method of transferring data in a flash storage device comprising a random access memory and a plurality of channels of a flash array is provided. The method comprises receiving a plurality of data segments from a host system, storing the plurality of data segments in the random access memory, allocating the plurality of data segments among the plurality of channels of the flash array, and writing the allocated data segments from the random access memory to the respective channels of the flash array.

Abstract: Methods and systems for the prioritized erasure of data blocks in a flash storage device are provided. A data block in the flash storage device is selected for erasure based upon the number of valid data segments therein, thereby minimizing the number of data segments that are carried over to another data block before erasing the selected data block. The overhead of write operations in the flash storage device is therefore greatly reduced, and the overall performance thereof greatly increased. A method for managing memory operations in a flash storage device having a plurality of data blocks comprises the steps of selecting one of the plurality of data blocks for erasure based upon a number of valid data segments therein, and erasing the selected one of the plurality of data blocks.

Abstract: The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives wherein R1, R2, R3, X1, and A are defined herein. The compounds are useful as potassium ion channel inhibitors.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: The invention relates to a display system having one or more collapsible crates and at least one creative panel that can be employed to display to various types of items, products, goods or information for sale or non-sale display. The collapsible crates of the invention are less expensive to make and ship, and can be reused over and over again, thus, further decreasing shipping costs over the life of the display system.