Patents by Inventor Simon McKenzie Cool

Simon McKenzie Cool has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparin and heparan sulphate oligosaccharides
    Patent number: 11806362
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: November 7, 2023
    Assignee: Agency for Science, Technology and Research
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe, Sadasivam Murali
  • HEPARIN AND HEPARAN SULPHATE OLIGOSACCHARIDES
    Publication number: 20220347205
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Application
    Filed: April 25, 2022
    Publication date: November 3, 2022
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe, Sadasivam Murali
  • Heparin and heparan sulphate oligosaccharides
    Patent number: 11331337
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: May 17, 2022
    Assignee: Agency for Science, Technology and Research
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe, Sadasivam Murali
  • HEPARIN AND HEPARAN SULPHATE OLIGOSACCHARIDES
    Publication number: 20210161945
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 3, 2021
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe
  • Glycosaminoglycans
    Patent number: 10245301
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 2, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Glycosaminoglycans
    Patent number: 10220054
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: March 5, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Isolation and Identification of Glycosaminoglycans
    Publication number: 20180360916
    Abstract: The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
    Type: Application
    Filed: June 27, 2018
    Publication date: December 20, 2018
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Heparan sulphate which binds BMP2
    Patent number: 10086044
    Abstract: The invention relates to heparan sulphate GAGs obtained by affinity chromatography using the heparin-binding domain of BMP2. The GAGs were obtained from osteoblast extracellular matrix and from a commercially available heparan sulfate (Celsus HS).
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: October 2, 2018
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Glycosaminoglycans
    Publication number: 20170106012
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Application
    Filed: October 27, 2016
    Publication date: April 20, 2017
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Glycosaminoglycans
    Publication number: 20160375099
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Glycosaminoglycans
    Patent number: 9498494
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: November 22, 2016
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Therapeutic bone growth and regeneration
    Patent number: 9205106
    Abstract: The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.
    Type: Grant
    Filed: September 7, 2009
    Date of Patent: December 8, 2015
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon McKenzie Cool, Victor Nurcombe
  • Glycosaminoglycans
    Publication number: 20130045249
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Application
    Filed: September 5, 2012
    Publication date: February 21, 2013
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Methods of culturing mesenchymal stem cells
    Patent number: 8287853
    Abstract: Stem cells obtained through in vitro culture with heparan sulphate are described.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: October 16, 2012
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon McKenzie Cool, Victor Nurcombe
  • Heparan Sulphate Which Binds BMP2
    Publication number: 20110165132
    Abstract: The invention relates to heparan sulphate GAGs obtained by affinity chromatography using the heparin-binding domain of BMP2. The GAGs were obtained from osteoblast extracellular matrix and from a commercially available heparan sulfate (Celsus HS).
    Type: Application
    Filed: September 11, 2009
    Publication date: July 7, 2011
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Therapeutic Bone Growth and Regeneration
    Publication number: 20110165218
    Abstract: The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.
    Type: Application
    Filed: September 7, 2009
    Publication date: July 7, 2011
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe
  • Isolation and Identification of Glycosaminoglycans
    Publication number: 20110159071
    Abstract: The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
    Type: Application
    Filed: February 19, 2009
    Publication date: June 30, 2011
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • STEM CELLS
    Publication number: 20090148420
    Abstract: Stem cells obtained through in vitro culture with heparan sulphate are described.
    Type: Application
    Filed: August 8, 2008
    Publication date: June 11, 2009
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie COOL, Victor NURCOMBE