Abstract: Methods for treating malignancies including multiple myeloma (MM), methods for expanding immune cells, methods for characterizing and enhancing anti-tumor functions of immune cells, and methods for characterizing immune cell responses to agonist immunotherapies including decoy-resistant IL-18 (DR-18) therapies.

Abstract: Methods for treating malignancies such as hematological malignancies, including myeloma, that are resistant to tissue transplant treatments and that can be characterized by an increased risk of relapse or graft-versus-host disease (GVHD). A method for treatment includes transplanting a tissue that includes T cells to a subject, enriching for a stem-like memory T cell phenotype in the T cells, and stimulating the T cells to enhance a graft-versus-tumor (GVT) response of the T cells. The enriching for the stem-like memory T cell phenotype can include depletion of exhausted alloreactive T cells with a post-transplant cyclophosphamide (PT-Cy) treatment and the stimulating the T cells can include an agonist immunotherapy, such as a decoy-resistant IL-18 (DR-18) treatment, to enhance the GVT response.

Abstract: This disclosure is directed to bicycle storage systems and, in particular, to shared-use bicycle systems. Several embodiments herein are directed to a shared-use bicycle system, comprising a bicycle having a locking device and an accessory-receiving area. The locking device can extend horizontally from the bicycle, and the accessory-receiving area being positioned below the locking device. The shared-use bicycle system also comprises a bicycle rack having a horizontally-extending rigid member with at least one opening thereon to receive the locking device of the bicycle in a secured manner. When the bicycle is received in the at least one opening of the bicycle rack in the secured manner, access to the accessory-receiving area of the bicycle is restricted by the horizontally-extending rigid member.

Abstract: This disclosure is directed to bicycle storage systems and, in particular, to shared-use bicycle systems. Several embodiments herein are directed to a shared-use bicycle system, comprising a bicycle having a locking device and an accessory-receiving area. The locking device can extend horizontally from the bicycle, and the accessory-receiving area being positioned below the locking device. The shared-use bicycle system also comprises a bicycle rack having a horizontally-extending rigid member with at least one opening thereon to receive the locking device of the bicycle in a secured manner. When the bicycle is received in the at least one opening of the bicycle rack in the secured manner, access to the accessory-receiving area of the bicycle is restricted by the horizontally-extending rigid member.

Abstract: Embodiments of the present invention relate to methods, systems and computer-readable media for transliteration between Cyrillic and Latin script in a software product. An embodiment of this transliteration system and method comprises loading a text of characters and words in one of a Cyrillic or Latin script into a character transliteration module. This module converts each character in the one of a Cyrillic or Latin script into a corresponding opposite transliterated Cyrillic or Latin character. Then each word is examined in a word capitalization and exception module that compares each transliterated word against a set of predetermined grammatical rules to determine whether there are exceptions in capitalization. If there are, then appropriate internal capitalization of characters is added. Each word of the text to be transliterated is sequentially examined and converted until all words have been examined.