Abstract: A golf club or part thereof may include a ball-strike head 1, a hosel 2 having a shank 5 that extends along at least part of, and that engages with, the head, biasing means (eg a spring 9) that provides a locking force that seeks to move the head 1 and hosel apart 2 and, in doing so, causes the head to remain locked in one or other of a selection of loft settings 4. The club or part thereof being such that hand force can be applied to move the head 1 inwards to overcome the locking force to free the head to be turned into another of the loft settings 4. The arrangement is such that subsequent reverse movement of the head will cause it to be locked in that other setting.

Abstract: Disclosed herein are improved methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. Among other things, provided herein is a gene therapy construct encoding a non-naturally occurring codon-optimized transcription factor (ZFP-TF) comprising a zinc-finger protein (ZFP) sequence and a sequence encoding a transcriptional repression domain, wherein the ZFP-TF expression is driven by a phosphoglycerate kinase 1 (PGK), ubiquitin C (UBC), an EFS, or an EF1alpha promoter.

Abstract: The invention comprises a post having a pole (1), a rigid sleeve (2) that has at least two inwardly extending locking 2024/054121 nodes (4a, 4b) and a screw fastener (3). The post is such that a base portion of the pole (1) is lodged within the ground and the pole cantilevers upright. The sleeve (2) extends around and covers at least most of the portion of the post that is cantilevered. The fastener (3) exerts pressure on the pole (1) to cause at least two substantially planar contact surfaces (5a, 5b) of the pole (1) to wedge between the nodes (4a, 4b) to prevent the post (1) from rotating with respect to the sleeve (2).

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

Abstract: A golf club or part thereof may include a ball-strike head 1, a hosel 2 having a shank 5 that extends along at least part of, and that engages with, the head, biasing means (eg a spring 9) that provides a locking force that seeks to move the head 1 and hosel apart 2 and, in doing so, causes the head to remain locked in one or other of a selection of loft settings 4. The club or part thereof being such that hand force can be applied to move the head 1 inwards to overcome the locking force to free the head to be turned into another of the loft settings 4. The arrangement is such that subsequent reverse movement of the head will cause it to be locked in that other setting.

Abstract: In a preferred embodiment of the invention there is a post comprising a plurality of poles 5 located in and extending from a ground surface adjacent to one another. A sleeve 1 is arranged around the poles 5 so that the sleeve and poles combine to provide a shaft. In this embodiment each pole has a tapered ground-engaging end 6 and the sleeve has a large compartment 2 for two of the poles 5 and a small compartment 3 for one of the poles.

Abstract: The disclosure relates to optimized polynucleotide sequences for LAMP-2B, expression cassettes, vectors, and methods of use thereof in treating disease, e.g. Danon disease.

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

Abstract: The disclosure relates to optimized polynucleotide sequences for LAMP-2B, expression cassettes, vectors, and methods of use thereof in treating disease, e.g. Danon disease.

Abstract: The disclosure relates to optimized polynucleotide sequences for LAMP-2B, expression cassettes, vectors, and methods of use thereof in treating disease, e.g. Danon disease.

Abstract: A variable geometry turbine comprising a turbine wheel mounted for rotation about a turbine axis within a housing. The housing defines an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls. The turbine further comprises a cylindrical sleeve that is axially movable across the annular inlet to vary the size of a gas flow path through the inlet. The annular inlet is divided into at least two axially offset inlet passages. The inner diameter of the sleeve is greater than the inner diameter of the inlet passages.

Abstract: A variable geometry turbine comprising a turbine wheel mounted for rotation about a turbine axis within a housing. The housing defines an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls. The turbine further comprises a cylindrical sleeve that is axially movable across the annular inlet to vary the size of a gas flow path through the inlet. The annular inlet is divided into at least two axially offset inlet passages. The inner diameter of the sleeve is greater than the inner diameter of the inlet passages.

Abstract: A variable geometry turbine comprising a turbine wheel mounted for rotation about a turbine axis within a housing. The housing defines an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls. The turbine further comprises a cylindrical sleeve that is axially movable across the annular inlet to vary the size of a gas flow path through the inlet. The annular inlet is divided into at least two axially offset inlet passages. The inner diameter of the sleeve is greater than the inner diameter of the inlet passages.

Abstract: A variable geometry turbine comprising a turbine wheel mounted for rotation about a turbine axis within a housing. The housing defines an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls. The turbine further comprises a cylindrical sleeve that is axially movable across the annular inlet to vary the size of a gas flow path through the inlet. The annular inlet is divided into at least two axially offset inlet passages. The inner diameter of the sleeve is greater than the inner diameter of the inlet passages.

Abstract: A variable geometry turbine comprising a turbine wheel mounted for rotation about a turbine axis within a housing. The housing defines an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls. The turbine further comprises a cylindrical sleeve that is axially movable across the annular inlet to vary the size of a gas flow path through the inlet. The annular inlet is divided into at least two axially offset inlet passages. The inner diameter of the sleeve is greater than the inner diameter of the inlet passages.

Abstract: According to an aspect of the invention, there is provided a variable geometry turbine comprising: a turbine wheel mounted for rotation about a turbine axis within a housing, the housing defining an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls; and a cylindrical sleeve axially movable across the annular inlet to vary the size of a gas flow path through the annular inlet, the annular inlet being divided into at least two axially offset inlet portions; and a ring-like seal adjacent a free end of the sleeve, at least a part of the ring-like seal being located in-between the sleeve and the inlet portions, or a structure defining the inlet portions.

Abstract: A variable geometry turbine comprises a turbine wheel mounted for rotation about a turbine axis within a housing, the housing defining an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls; and a cylindrical sleeve axially movable across the annular inlet to vary the size of a gas flow path through the inlet; wherein the annular inlet is divided into at least three axially offset annular inlet portions by two or more axially spaced annular baffles disposed between the first and second inlet sidewalls; inlet vanes extending axially into at least one of the inlet portions and defining circumferentially adjacent inlet passages; and wherein each of at least two of said baffles extends radially inboard of inlet vanes which extend into at least one of the inlet portions axially adjacent the respective baffle, and wherein a distance between an inner diameter of a first baffle of said at least two of said baffles and a trailing edge of a radially innermost vane in one of

Abstract: A variable geometry turbine comprising a turbine wheel mounted for rotation about a turbine axis within a housing. The housing defines an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls. The turbine further comprises a cylindrical sleeve that is axially movable across the annular inlet to vary the size of a gas flow path through the inlet. The annular inlet is divided into at least two axially offset inlet passages. The inner diameter of the sleeve is greater than the inner diameter of the inlet passages.

Abstract: According to an aspect of the invention, there is provided a variable geometry turbine comprising: a turbine wheel mounted for rotation about a turbine axis within a housing, the housing defining an annular inlet surrounding the turbine wheel and defined between first and second inlet sidewalls; and a cylindrical sleeve axially movable across the annular inlet to vary the size of a gas flow path through the annular inlet, the annular inlet being divided into at least two axially offset inlet portions; and a ring-like seal adjacent a free end of the sleeve, at least a part of the ring-like seal being located in-between the sleeve and the inlet portions, or a structure defining the inlet portions.

Abstract: A track assembly for a vehicle seat includes a first track member and a reinforcing member. The first track member has a first portion defining a first set of apertures configured to receive a locking device. The reinforcing member, which may be in the form of a plate, is coupled to the first portion and defines a second set of apertures corresponding to the first set of apertures. The second set of apertures are also configured to receive the locking device. The reinforcing member is configured to reinforce the first track member in an area around and between the first set of apertures.