Patents by Inventor Simon Nicholas Waddington

Simon Nicholas Waddington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE THERAPY VECTOR FOR eEF1A2 AND USES THEREOF
    Publication number: 20230330265
    Abstract: Provided herein is a gene therapy for neurological disease using a recombinant adeno-associated virus (rAAV) virion as a vector to express an eEF1A2 protein or functional variant thereof. The rAAV virion may use a neuron-specific promoter, e.g., a human synapsin 1 (hSYN) promoter. The capsid may be an AAV9 capsid or functional variant thereof. Other promoters or capsids may be used. Further provided are methods of treatment, such as by intracerebrally and/or intravenously of the rAAV virion, and other compositions and methods.
    Type: Application
    Filed: July 21, 2021
    Publication date: October 19, 2023
    Inventors: Simon Nicholas WADDINGTON, Rajvinder KARDA, Christopher Dean HERZOG, Joanna NG, Chester SACRAMENTO, Stephanie SCHORGE, David RICKS
  • SOMATOTRANSGENIC BIOIMAGING
    Publication number: 20100175139
    Abstract: The invention relates to modelling diseases, to screening for compounds that modulate such diseases and to as-saying drug metabolism and toxicity in non-human transgenic animals, by a novel technique developed by the inventors known as “somatotransgenic bioimaging”.
    Type: Application
    Filed: March 13, 2008
    Publication date: July 8, 2010
    Inventors: Simon Nicholas Waddington, Tristan Rowntree McKay