Patents by Inventor Simon OLIVARES

Simon OLIVARES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human application of engineered chimeric antigen receptor (CAR) T-cells
    Patent number: 11786582
    Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: October 17, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J N Cooper, Hiroki Torikai, Ling Zhang, Helen Huls, Feng Wang-Johanning, Lenka Hurton, Simon Olivares, Janani Krishnamurthy
  • CHIMERIC ANTIGEN RECEPTORS (CAR) AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20230312675
    Abstract: Chimeric antigen receptors (CARs) and CAR-expressing T cells are provided that can specifically target cells that express an elevated level of a target antigen. Likewise, methods for specifically targeting cells that express elevated levels of antigen (e.g., cancer cells) with CAR T-cell therapies are provided.
    Type: Application
    Filed: January 11, 2023
    Publication date: October 5, 2023
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J.N. COOPER, Hillary Gibbons CARUSO, Simon OLIVARES, Sonny ANG
  • GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
    Publication number: 20220072041
    Abstract: Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.
    Type: Application
    Filed: July 9, 2021
    Publication date: March 10, 2022
    Inventors: Laurence J.N. COOPER, Harjeet SINGH, Helen HULS, Simon OLIVARES, Bipulendu JENA, Krina PATEL
  • HUMAN APPLICATION OF ENGINEERED CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS
    Publication number: 20220062396
    Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
    Type: Application
    Filed: April 6, 2021
    Publication date: March 3, 2022
    Inventors: Laurence JN COOPER, Hiroki TORIKAI, Ling ZHANG, Helen HULS, Feng WANG-JOHANNING, Lenka HURTON, Simon OLIVARES, Janani KRISHNAMURTHY
  • CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING
    Publication number: 20210324071
    Abstract: Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
    Type: Application
    Filed: February 26, 2021
    Publication date: October 21, 2021
    Inventors: Laurence J.N. COOPER, Ana Beatriz KORNGOLD, Brian A. RABINOVICH, Harjeet SINGH, Simon OLIVARES
  • Chimeric antigen receptor molecules and uses thereof
    Patent number: 11059879
    Abstract: Chimeric antigen receptor (CAR) polypeptides are provided comprising an antigen binding domain; a hinge domain; a transmembrane domain and an intracellular signaling domain, wherein the CAR polypeptide binds to a target antigen and wherein the antigen binding domain comprises HCDR sequences from a first antibody that binds to the target antigen and LCDR sequences from a second antibody that binds to the target antigen. In certain aspects, the target antigen is CD123.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: July 13, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Radhika Thokala, Laurence J.N. Cooper, Simon Olivares
  • CHIMERIC ANTIGEN RECEPTORS (CAR) AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20200102366
    Abstract: Chimeric antigen receptors (CARs) and CAR-expressing T cells are provided that can specifically target cells that express an elevated level of a target antigen. Likewise, methods for specifically targeting cells that express elevated levels of antigen (e.g., cancer cells) with CAR T-cell therapies are provided.
    Type: Application
    Filed: October 14, 2019
    Publication date: April 2, 2020
    Inventors: Laurence J.N. COOPER, Hillary Gibbons CARUSO, Simon OLIVARES, Sonny ANG
  • HUMAN APPLICATION OF ENGINEERED CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS
    Publication number: 20200085929
    Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 19, 2020
    Inventors: Laurence JN COOPER, Hiroki TORIKAI, Ling ZHANG, Helen HULS, Feng WANG-JOHANNING, Lenka HURTON, Simon OLIVARES, Janani KRISHNAMURTHY
  • CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING
    Publication number: 20190085079
    Abstract: Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
    Type: Application
    Filed: September 28, 2018
    Publication date: March 21, 2019
    Inventors: Laurence J.N. Cooper, Ana Beatriz Korngold, Brian A. Rabinovich, Harjeet Singh, Simon Olivares
  • CHIMERIC ANTIGEN RECEPTOR MOLECULES AND USES THEREOF
    Publication number: 20190055299
    Abstract: Chimeric antigen receptor (CAR) polypeptides are provided comprising an antigen binding domain; a hinge domain; a transmembrane domain and an intracellular signaling domain, wherein the CAR polypeptide binds to a target antigen and wherein the antigen binding domain comprises HCDR sequences from a first antibody that binds to the target antigen and LCDR sequences from a second antibody that binds to the target antigen. In certain aspects, the target antigen is CD123.
    Type: Application
    Filed: October 27, 2016
    Publication date: February 21, 2019
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Radhika THOKALA, Laurence J.N. COOPER, Simon OLIVARES
  • Chimeric antigen receptors and methods of making
    Patent number: 10125193
    Abstract: Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: November 13, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J. N. Cooper, Ana Beatriz Korngold, Brian A. Rabinovich, Harjeet Singh, Simon Olivares
  • GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
    Publication number: 20170333480
    Abstract: Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 23, 2017
    Inventors: Laurence J.N. COOPER, Harjeet SINGH, Helen HULS, Simon OLIVARES, Bipulendu JENA, Krina PATEL
  • HUMAN APPLICATION OF ENGINEERED CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS
    Publication number: 20170224798
    Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 10, 2017
    Inventors: Laurence JN COOPER, Hiroki TORIKAI, Ling ZHANG, Helen HULS, Feng WANG-JOHANNING, Lenka HURTON, Simon OLIVARES, Janani KRISHNAMURTHY
  • CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING
    Publication number: 20170183407
    Abstract: Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.
    Type: Application
    Filed: February 16, 2015
    Publication date: June 29, 2017
    Inventors: Laurence J.N. COOPER, Ana Beatriz KORNGOLD, Brian A. RABINOVICH, Harjeet SINGH, Simon OLIVARES
  • CHIMERIC ANTIGEN RECEPTORS (CAR) AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20170158749
    Abstract: Chimeric antigen receptors (CARs) and CAR-expressing T cells are provided that can specifically target cells that express an elevated level of a target antigen. Likewise, methods for specifically targeting cells that express elevated levels of antigen (e.g., cancer cells) with CAR T-cell therapies are provided.
    Type: Application
    Filed: April 23, 2015
    Publication date: June 8, 2017
    Inventors: Laurence J.N. COOPER, Hillary Gibbons CARUSO, Simon OLIVARES, Sonny ANG
  • Human application of engineered chimeric antigen receptor (CAR) T-cells
    Patent number: 9629877
    Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: April 25, 2017
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence JN Cooper, Hiroki Torikai, Ling Zhang, Helen Huls, Feng Wang-Johanning, Lenka Hurton, Simon Olivares, Janani Krishnamurthy
  • HUMAN APPLICATION OF ENGINEERED CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS
    Publication number: 20160158285
    Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
    Type: Application
    Filed: May 14, 2014
    Publication date: June 9, 2016
    Inventors: Laurence JN COOPER, Hiroki TORIKAI, Ling ZHANG, Helen HULS, Feng WANG-JOHANNING, Lenka HURTON, Simon OLIVARES, Janani KRISHNAMURTHY