Abstract: The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

Abstract: Provided are compounds and method for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat disease, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Compounds provided are of Formula (I).

Abstract: The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

Abstract: Described herein are compounds that are ULK1/2 inhibitors and their use in the treatment of disorders such as cancers.

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: •B is an aryl or heteroaryl group optionally substituted by one or more R10 groups; and *X is selected from 0, (CR11R12)p and (CR11R12)p CO. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, • B is a saturated or partially unsaturated monocyclic or bicyclic, heterocyclic group optionally substituted by one or more R 10 groups; *X is selected from SO2, CO2, CO, CONR11 and (CR12R13) p. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: •B is an aryl or heteroaryl group optionally substituted by one or more R10 groups; and *X is selected from 0, (CR11R12)p and (CR11R12)p CO. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, • B is a saturated or partially unsaturated monocyclic or bicyclic, heterocyclic group optionally substituted by one or more R 10 groups; * X is selected from SO2, CO2, CO, CONR11 and (CR12 R13) p. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data component is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data component is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: The novel compounds of formula (I) of the instant invention are selective kappa opioid agonists useful in the treatment of arthritis, hypertension, pain, inflammation, migraine, inflammatory disorders of the gastrointestinal tract, IBS, and psoriasis. The compounds, novel intermediates useful in their preparations and pharmaceutical compositions containing them, are part of the invention.

Abstract: The compounds of the instant invention as those of Formula I ##STR1## or a pharmaceutically acceptable salt thereof are peripherally selective kappa opioid agonists that are useful in treating pain, inflammation, psoriasis and irritable bowel syndrome.

Abstract: The compounds of the instant invention are ligands for the NK.sub.2 receptor. The compounds are modified at the C-terminus to provide various amide isostere derivatives expected to be useful in treating obesity, anxiety, gastrointestinal ulcers, pain, stroke, and inflammation. Pharmaceutical compositions and methods of using the compounds are also included.