Abstract: The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, • B is a saturated or partially unsaturated monocyclic or bicyclic, heterocyclic group optionally substituted by one or more R 10 groups; *X is selected from SO2, CO2, CO, CONR11 and (CR12R13) p. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: •B is an aryl or heteroaryl group optionally substituted by one or more R10 groups; and *X is selected from 0, (CR11R12)p and (CR11R12)p CO. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: An attachment for a hair styling apparatus includes an air inlet for receiving airflow from the hair styling apparatus, an air outlet and a duct for conveying air from the air inlet to the air outlet, wherein at least part of an external surface of the duct comprises an arrangement of tactile ribbed protrusions. The ribbed surface provides thermal insulation from the duct which may become warm when heated airflow is received from the hair styling apparatus and also serves as a visual guide to the user as to where they should place their fingers when grasping the attachment.

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data component is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly.

Abstract: A wand assembly for a cleaning appliance includes a handle portion having a channel formed therethrough; a tubular wand received within the channel and moveable between a first position and a second position; a locking mechanism having a lock position and an unlock position and preventing the wand from moving from the first position when in the lock position; and a release mechanism mounted to the wand and which can be actuated to move the locking mechanism from the lock position to the unlock position. The release mechanism is actuated by relative movement of the release mechanism with respect to the wand.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly. A flexible sealing member is located between the outer casing and the impeller housing.

Abstract: A fan assembly for creating an air current includes a nozzle mounted on a base. The base comprises an outer casing, an impeller housing located within the outer casing, the impeller housing having an air inlet and an air outlet, an impeller located within the impeller housing and a motor for driving the impeller to create an air flow through the impeller housing. The nozzle includes an interior passage for receiving the air flow from the air outlet of the impeller housing and a mouth through which the air flow is emitted from the fan assembly. A flexible sealing member is located between the outer casing and the impeller housing.

Abstract: A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data component is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components.

Abstract: A wand assembly for a cleaning appliance includes a handle portion having a channel formed therethrough; a tubular wand received within the channel and moveable between a first position and a second position; a locking mechanism having a lock position and an unlock position and preventing the wand from moving from the first position when in the lock position; and a release mechanism mounted to the wand and which can be actuated to move the locking mechanism from the lock position to the unlock position. The release mechanism is actuated by relative movement of the release mechanism with respect to the wand.

Abstract: The novel compounds of formula (I) of the instant invention are selective kappa opioid agonists useful in the treatment of arthritis, hypertension, pain, inflammation, migraine, inflammatory disorders of the gastrointestinal tract, IBS, and psoriasis. The compounds, novel intermediates useful in their preparations and pharmaceutical compositions containing them, are part of the invention.