Abstract: Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.

Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.

Abstract: Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.

Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.

Abstract: The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.

Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

Abstract: The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

Abstract: A visor shield for shielding a marine electronic device from sunlight, weather and spray includes a visor body having a base portion for attachment to an electronic device, and a protruding portion extending from the base portion and sized to extend out from the electronic device to shade a front face of the electronic device. The base portion and the protruding portion can be formed of a unitary plastic part. The base portion can comprise a wall continuous with the protruding portion. A compressible seal can be attached to a surface of the wall and arranged to be compressed against a housing of the electronic device when the base portion is attached to the electronic device.

Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

Abstract: A visor shield for shielding a marine electronic device from sunlight, weather and spray includes a visor body having a base portion for attachment to an electronic device, and a protruding portion extending from the base portion and sized to extend out from the electronic device to shade a front face of the electronic device. The base portion and the protruding portion can be formed of a unitary plastic part. The base portion can comprise a wall continuous with the protruding portion. A compressible seal can be attached to a surface of the wall and arranged to be compressed against a housing of the electronic device when the base portion is attached to the electronic device.

Abstract: A propeller shield apparatus for mounting to a trolling motor having an exposed propeller with a horizontal axis includes a vertical fin and an arcuate propeller shield. The arcuate propeller shield is oriented concave downward and fixed to the vertical fin. The vertical fin is carried by the trolling motor. The vertical fin spaces the propeller shield above the propeller. A curved bracket is provided, connected to the vertical fin, and is clamped to the trolling motor. Angular fins can be provided at opposite ends of the propeller shield which extend substantially radially from the horizontal axis.

Abstract: A propeller shield apparatus for mounting to a trolling motor having an exposed propeller with a horizontal axis includes a vertical fin and an arcuate propeller shield. The arcuate propeller shield is oriented concave downward and fixed to the vertical fin. The vertical fin is carried by the trolling motor. The vertical fin spaces the propeller shield above the propeller. A curved bracket is provided, connected to the vertical fin, and is clamped to the trolling motor. Angular fins can be provided at opposite ends of the propeller shield which extend substantially radially from the horizontal axis.

Abstract: A safety rail assembly for an access hatch with a hatch frame which defines an opening; extends around at least a part of the hatch frame and includes guard members interconnection members which extend around the hatch frame, and support members for supporting the guard members at a position elevated above the hatch frame, where each interconnection member has a spacer member secured therto between the ends thereof, and each spacer member has a body portion by which the spacer member is secured to an interconnection member and a head portion for bearing firmly against an outwardly facing surface of the hatch frame.

Abstract: A safety rail assembly for an access hatch of a kind comprising a hatch frame which defines an opening, is adapted to extend around at least a part of a hatch frame thereby to safeguard personnel from inadvertent entry into the hatch opening, said safety rail assembly comprising guard members which in use extend at least in part substantially horizontally, elongate rigid interconnection members which in use extend substantially horizontally around the hatch frame, support members for supporting the guard members at a position elevated above the hatch framer said support members each having associated therewith a foot portion for resting in a free-standing manner on a support surface surrounding the hatch frame, and said support members each having secured thereto a connector device for securing an end region of one interconnection member relative to an end region of another of the interconnection members, and each said interconnection member having a spacer member secured thereto, between the ends thereof, ea

Abstract: A safety rail assembly for an access hatch of a kind comprising a hatch frame which defines an opening, said safety rail assembly being adapted to extend around at least a part of a hatch frame thereby to safeguard personnel from inadvertent entry into the hatch opening from at least two mutually perpendicular directions, said safety rail assembly comprising guard members which in use extend at least in part substantially horizontally and support members for supporting the guard members at a position elevated above the hatch frame, said support members each having associated therewith a foot portion for resting in a free-standing manner on a support surface surrounding the hatch frame, and said support members having a resistance to toppling in a direction towards or a direction away from the opening defined by the frame by at least one of a) structural connection to a part of the safety rail assembly at an opposite side of the frame, and b) co-operation of the safety rail assembly with an abutment surface de

Abstract: A structural interconnection device for attachment of an elongate member to a rigid frame includes at least one flange portion adapted for attachment to the rigid frame and a receiving portion. The receiving portion includes a locking mechanism for selectively releasably securing thereto an end portion of an elongate member. The flange portion has a location surface for bearing against the rigid frame. The location surface lies, in use, in a plane which is substantially parallel with a longitudinal axis of an end portion of an elongate member secured to the receiving portion. The plane of the location surface lies, in use, in a plane displaced from the longitudinal axis of the end portion of the elongate member.

Abstract: A safety rail assembly for an access hatch of a kind comprising a hatch frame which defines an opening, said safety rail assembly being adapted to extend around at least a part of a hatch frame thereby to safeguard personnel from inadvertent entry into the hatch opening from at least two mutually perpendicular directions, said safety rail assembly comprising guard members which in use extend at least in part substantially horizontally, and support members for supporting the guard members at a position elevated above the hatch frame, said support members each having associated therewith a foot portion for resting in a free-standing manner on a support surface surrounding the hatch frame, and said support members having a resistance to toppling in a direction towards or a direction away from the opening defined by the frame by at least one of a) structural connection to a part of the safety rail assembly at an opposite side of the frame, and b) co-operation of the safety rail assembly with an abutment surface d