Abstract: Method and apparatus for determining a route from a source location to a final destination using a vehicle navigation system having a map database. At least one intermediate destination is determined from the map database, each intermediate destination being at the other end of an intermediate route from the source location. A cost value is calculated for each intermediate destination. A best intermediate destination is selected from the at least one intermediate destination, the cost value corresponding to the best intermediate destination being lower than the cost values corresponding to any other intermediate destinations. The intermediate route corresponding to the best intermediate destination is then communicated to the user of the vehicle navigation system while a remainder route to the final destination is determined.

Abstract: The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen-derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.

Abstract: The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen-derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.

Abstract: Apparatus for producing a light mask for balancing light across a display area of a vehicle instrument cluster comprises a camera, a digitiser and a computer. An image of the display area is obtained and digitized to produce data relating to the illumination levels of the image at a plurality of pixels. The illumination levels are used to calculate an appropriate light mask for the display area on the basis of the transmissive density of the masking ink used and or a reference illumination value relating to the least lit part of the display area which it is desired to illuminate. The light mask comprises an array of dots having a diameter related to the amount of attenuation required in the area in which the dot is located. Up to three masking layers may be provided if a single layer is insufficient to produce the required attenuation with the chosen masking ink. Balanced coverlays can readily be produced, and the number of masking layers required can also be reduced.