Patents by Inventor Simon Pimstone

Simon Pimstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cholesterol transport gene
    Publication number: 20070298420
    Abstract: Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
    Type: Application
    Filed: November 28, 2006
    Publication date: December 27, 2007
    Inventors: Alan Attie, Mark Cook, Mark Gray-Keller, Michael Hayden, Simon Pimstone, Angela Brooks-Wilson
  • Cholesterol transport gene
    Patent number: 7166584
    Abstract: Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: January 23, 2007
    Assignees: Wisconsin Alumni Research Foundation, Xenon Genetics, Inc.
    Inventors: Alan D. Attie, Mark Cook, Mark P. Gray-Keller, Michael R. Hayden, Simon Pimstone, Angela R. Brooks-Wilson
  • Methods and reagents for modulating cholesterol levels
    Publication number: 20050136421
    Abstract: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
    Type: Application
    Filed: April 5, 2004
    Publication date: June 23, 2005
    Inventors: Michael Hayden, Angela Brooks-Wilson, Simon Pimstone