Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Abstract: The present invention relates to a terrarium of the closed type which includes a base for holding a plant (typically tropical plant varieties such as moss) and any excess moisture, and a removable lid which together with the base forms an enclosure around the plant and creates a humid and sheltered environment. The terrarium may include a removable lid which has an internal upper surface that is shaped to direct condensate forming on the upper surface of the lid to a particular area of the plant. The terrarium may include a base and lid having overlapping portions wherein the overlapping portions include edge deviations or apertures that may be brought into co-alignment to provide for no, partial or full aeration.

Abstract: The invention provides novel substituted pyridyl piperidine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

Abstract: The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

Abstract: The invention provides novel substituted pyridyl piperidine compounds according to Formula (I) which are Wnt pathway inhibitors, their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

Abstract: The present invention relates to a terrarium of the closed type which includes a base for holding a plant (typically tropical plant varieties such as moss) and any excess moisture, and a removable lid which together with the base forms an enclosure around the plant and creates a humid and sheltered environment. The terrarium may include a removable lid which has an internal upper surface that is shaped to direct condensate forming on the upper surface of the lid to a particular area of the plant. The terrarium may include a base and lid having overlapping portions wherein the overlapping portions include edge deviations or apertures that may be brought into co-alignment to provide for no, partial or full aeration.

Abstract: An apparatus comprising first and second fluid intakes, a pump, and a sample chamber, may be positioned in a borehole penetrating a subterranean formation. A method of use thereof may comprise drawing fluid from the subterranean formation and into the first and second fluid intakes using the pump, discharging into the borehole at least a portion of the fluid drawn into the second fluid intake, and selectively diverting at least a portion of the fluid drawn into the first fluid intake to the sample chamber.

Abstract: The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

Abstract: A method according to one or more aspects of the present disclosure includes moving a piston of a displacement unit to pump a fluid through first and second flowlines hydraulically connected to the displacement unit through a valve network. The method also includes monitoring flowing pressure in the first flowline and monitoring pressure in a first chamber of the displacement unit. The method further includes opening a first active valve of the valve network in response to the monitored pressure in the first chamber being about equal to or less than the monitored flowing pressure in the first flowline.

Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.

Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.

Abstract: A method according to one or more aspects of the present disclosure includes moving a piston of a displacement unit to pump a fluid through first and second flowlines hydraulically connected to the displacement unit through a valve network. The method also includes monitoring flowing pressure in the first flowline and monitoring pressure in a first chamber of the displacement unit. The method further includes opening a first active valve of the valve network in response to the monitored pressure in the first chamber being about equal to or less than the monitored flowing pressure in the first flowline.

Abstract: A method according to one or more aspects of the present disclosure comprises disposing a tool in a wellbore, the tool comprising a displacement unit for pumping a fluid at least partially through the tool, a first flowline hydraulically connected to the displacement unit through a valve network, and a second flowline hydraulically connected to the displacement unit; pumping a fluid from the first flowline to the second flowline; monitoring a pressure at a chamber of the displacement unit; and monitoring flowing pressure in the first flowline across the valve network from the displacement unit.

Abstract: An apparatus comprising first and second fluid intakes, a pump, and a sample chamber, may be positioned in a borehole penetrating a subterranean formation. A method of use thereof may comprise drawing fluid from the subterranean formation and into the first and second fluid intakes using the pump, discharging into the borehole at least a portion of the fluid drawn into the second fluid intake, and selectively diverting at least a portion of the fluid drawn into the first fluid intake to the sample chamber.

Abstract: An apparatus comprising first and second fluid intakes, a pump, and a sample chamber, may be positioned in a borehole penetrating a subterranean formation. A method of use thereof may comprise drawing fluid from the subterranean formation and into the first and second fluid intakes using the pump, discharging into the borehole at least a portion of the fluid drawn into the second fluid intake, and selectively diverting at least a portion of the fluid drawn into the first fluid intake to the sample chamber.

Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.

Abstract: A method according to one or more aspects of the present disclosure comprises disposing a tool in a wellbore, the tool comprising a displacement unit for pumping a fluid at least partially through the tool, a first flowline hydraulically connected to the displacement unit through a valve network, and a second flowline hydraulically connected to the displacement unit; pumping a fluid from the first flowline to the second flowline; monitoring a pressure at a chamber of the displacement unit; and monitoring flowing pressure in the first flowline across the valve network from the displacement unit.

Abstract: An apparatus comprising first and second fluid intakes, a pump, and a sample chamber, may be positioned in a borehole penetrating a subterranean formation. A method of use thereof may comprise drawing fluid from the subterranean formation and into the first and second fluid intakes using the pump, discharging into the borehole at least a portion of the fluid drawn into the second fluid intake, and selectively diverting at least a portion of the fluid drawn into the first fluid intake to the sample chamber.