Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: The present invention provides a peptide of a length from 10 to 50 amino acid residues, which comprises the amino acid sequence Xaa1KXaa2WXaa3Xaa4Xaa5Xaa6Xaa7W (SEQ ID NO: 1), wherein Xaa1, Xaa2 Xaa3, Xaa4 Xaa5, Xaa6 and Xaa7 are each independently any amino acid, in particular, which comprises the amino acid sequence LKXaa1WXaa2Xaa3GAIW (SEQ ID NO: 19), wherein Xaa1, Xaa2, and Xaa3, are each independently any amino acid. The invention also provides a conjugate comprising the peptide, a pharmaceutical composition comprising the conjugate, a method for delivering a cargo into a cell, a nucleic acid molecule encoding the peptide, and a host cell comprising said nucleic acid molecule.

Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.

Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.

Abstract: A drive cartridge comprises an actuating mechanism, in which a spindle can be guided in a hollow cylindrical drive element between two end positions at an axial distance from one another. The positions are defined by the axial length of the drive element. A dome-shaped casing surrounds the drive element in a non-rotatable and non-displaceable manner. The drive element has an external contour with an eccentric profile and the internal contour of the dome-shaped casing has a positive fit only in those areas of the drive element in which the permissible normal stress exceeds a predefined upper limit.

Abstract: An in vitro method for the analysis of the genetic predisposition of an individual to develop adverse effects related to non-metallic materials implanted into the body. The method comprises determining if in a biological sample from an individual there is/are present the antigen/s HLA-B*08 and/or HLA-DRB1*03 of the major histocompatibility complex. The use of a kit for carrying out the determination and the use of the antigens as genetic markers is also disclosed.

Abstract: The invention relates to a shut-off device comprising a housing which is to be connected to an adjacent conduit in a pressure-tight manner. A tubular passage is defined in the housing for a medium flowing through the conduit. Said device also comprises at least one sealing body which can be displaced by an articulated mechanism, by means of an adjusting drive that can be moved vertically in relation to the direction of flow, from an open position into a closed position in which the sealing contour of the at least one sealing body comes into contact with the tubular passage in a radially sealing manner. The articulated mechanism is guided parallel to the direction of displacement of the adjusting drive and comprises a bearing body to which the at least one sealing body is pivotably applied.

Abstract: The invention relates to a drive cartridge comprising an actuating mechanism, in which a spindle can be guided in a hollow cylindrical drive element between two end positions at an axial distance from one another, said positions being defined by the axial length of the drive element, and to a dome-shaped casing that surrounds the drive element in a non-rotatable and non-displaceable manner. The cartridge is characterized in that the drive element has an external contour with an eccentric profile and in that the internal contour of the dome-shaped casing has a positive fit only in those areas of the drive element in which the permissible normal stress exceeds a predefined upper limit.

Abstract: The invention relates to a method for producing an infrared transmitting fiber (50) comprising the steps of providing a preform (20) of the infrared transmitting fiber (50) to be produced, said preform (20) comprising a receptacle, which is the precursor of the fiber's cladding, and a solid solution provided inside said receptacle, said solid solution being the precursor of the fiber's core; heating the fiber's preform (20) up to a temperature in which the receptacle softens and the solid solution melts; collecting the flow generated by the softened receptacle; drawing the fiber (50) from the collected flow.

Abstract: The invention relates to a shut-off fitting comprising a housing which is connected to an adjacent pipeline in a pressure tight manner, the diameter of said pipeline defining a tubular passage in the housing. Said fitting also comprises at least one closing body which can be displaced between an open position and a closed position. The inventive shut-off fitting is characterized in that the at least one closing body can be displaced by an articulated mechanism, by means of an actuator which can be vertically displaced in relation to the flow direction, in such a way that it is arranged outside the tubular passage in its open position. The closing body has a contour which is adapted to the contour of the tubular passage, in the open position, and is located on the tubular passage in a radially sealing manner.

Abstract: The invention relates to a shut-off fitting comprising a housing which is connected to an adjacent pipeline in a pressure tight manner, the diameter of said pipeline defining a tubular passage in the housing. Said fitting also comprises at least one closing body which can be displaced between an open position and a closed position. The inventive shut-off fitting is characterized in that the at least one closing body can be displaced by an articulated mechanism, by means of an actuator which can be vertically displaced in relation to the flow direction, in such a way that it is arranged outside the tubular passage in its open position. The closing body has a contour which is adapted to the contour of the tubular passage, in the open position, and is located on the tubular passage in a radially sealing manner.