Abstract: The disclosure provides modified pegRNAs comprising one or more appended nucleotide structural motifs which increase the editing efficiency during prime editing, increase half-life in vivo, and increase lifespan in a cell. Modifications include, but are not limited to, an aptamer (e.g., prequeosim-1 riboswitch aptamer or “evopreQi-1”) or a variant thereof, a pseudoknot (the MMLV viral genome pseudoknot or “Mpknot-1”) or a variant thereof, a tRNA (e.g., the modified tRNA used by MMLV as a primer for reverse transcription) or a variant thereof, or a G-quadruplex or a variant thereof. The disclosure further provides prime editor complexes comprising the modified pegRNAs and having improved characteristics and/or performance, including stability, improved cellular lifespan, and improved editing efficiency.

Abstract: Disclosed is a sports camera, which comprises a main control unit, an image processing module, a motion parameter detection display module, a power supply module and a memory. The power supply module is connected with the main control unit and the image processing module. The image processing module comprises a digital signal processor and an image sensor, and the motion parameter detection display module comprises a GPS module and an acceleration sensor. The main control unit is connected with the digital signal processor, the memory, the GPS module and the acceleration sensor, and said digital signal processor is connected with the memory and the image sensor. The sports camera of the present invention can make sure that the image is normal and vertical when playing back the photo or video taken by the camera, thereby improving the image effect and increasing the ease of use of the sports camera.

Abstract: Disclosed is a sports camera, which comprises a main control unit, an image processing module, a motion parameter detection display module, a power supply module and a memory. The power supply module is connected with the main control unit and the image processing module. The image processing module comprises a digital signal processor and an image sensor, and the motion parameter detection display module comprises a GPS module and an acceleration sensor. The main control unit is connected with the digital signal processor, the memory, the GPS module and the acceleration sensor, and said digital signal processor is connected with the memory and the image sensor. The sports camera of the present invention can make sure that the image is normal and vertical when playing back the photo or video taken by the camera, thereby improving the image effect and increasing the ease of use of the sports camera.

Abstract: A sales data exchange system and method for exchanging data with customers and suppliers by integrating data in an internal information system and EDI data received. The sales data exchange system (1) includes a main database (16) for storing sales data; an EDI data translator (14) for converting a format of the sales data; an EDI data input and output device (13) for sending and receiving the sales data in EDI format; and a plurality of user clients (11) provided for users to send and receive EDI data. Each of the user clients includes a sales order control unit (12) for handling the sales data, the sales order control unit including an order management module (120) for managing sales orders data, a shipping management module (122) for managing shipping data, and an invoice management module (124) for managing invoice data, and an inventory management module (126).

Abstract: A system and method for managing cargo shipment according to inventory status and a received purchase order. The system interchanges data with a carrier MIS (5) and a customer MIS (4) via an EDI value added network (2). The system includes a main database (16) for storing purchase order data and inventory data, and a plurality of user clients (11) electronically connected with the main database. Each user client includes a shipment data management unit (12) for handling the data stored in the main database. The shipment data management unit includes a purchase order data search module (120) for users to search for the data on purchase orders set by customers, an inventory data search module (122) for users to search for inventory data relevant to the purchase orders, and a shipment schedule module (124) for scheduling shipment of cargo according to the purchase order data and the inventory data.

Abstract: A system and method for putting in-warehouse articles in a correct location in a warehouse (9), and for quickly retrieving out-warehouse articles from the warehouse. The system includes: a central management server (1) that includes a database (10) for storing in-warehouse article data, inventory data, out-warehouse article data and storage location information; a plurality of computing devices (3) located in different warehouses and linking to the central management server via an intranet (2); and a plurality of barcode printers (4) respectively linking to the plurality of computing devices for printing inventory data barcodes (14) that are attached to pallets (12).