Abstract: The disclosure provides modified pegRNAs comprising one or more appended nucleotide structural motifs which increase the editing efficiency during prime editing, increase half-life in vivo, and increase lifespan in a cell. Modifications include, but are not limited to, an aptamer (e.g., prequeosim-1 riboswitch aptamer or “evopreQi-1”) or a variant thereof, a pseudoknot (the MMLV viral genome pseudoknot or “Mpknot-1”) or a variant thereof, a tRNA (e.g., the modified tRNA used by MMLV as a primer for reverse transcription) or a variant thereof, or a G-quadruplex or a variant thereof. The disclosure further provides prime editor complexes comprising the modified pegRNAs and having improved characteristics and/or performance, including stability, improved cellular lifespan, and improved editing efficiency.

Abstract: An outdoor telecommunications equipment enclosure includes a dome, a base for receiving the dome, and a slide lock assembly for coupling the dome to the base. The slide lock assembly includes a housing coupled to one of the dome and the base and defining a channel and a slider positioned within the channel. The slider is moveable between a retracted position and an extended position for engaging the other one of the dome and the base. In one example embodiment, one of the slider and the housing includes multiple protrusions in contact with the other one of the slider and the housing. The protrusions inhibit surface contact between the slider and the housing. In another example embodiment, the slide lock assembly includes a gasket, seal and/or plug to inhibit ingress of debris into the slide lock assembly.

Abstract: A cooling fixture for molded components includes a support surface, at least two brackets coupled to the support surface, and at least one roller having a central axis. The roller is coupled between the brackets for rotating about its central axis and is positioned for contacting a portion of a molded component and rotating about its central axis as necessary to align the molded component and substantially inhibit gouging of the molded component when the molded component is placed in the cooling fixture for cooling. Additional cooling fixtures and related methods are also disclosed.

Abstract: According to some aspects of the present disclosure, systems and methods are disclosed for cabinet frames, including frame members coupled together via corner copulas. Frame members may include external and internal channels and surfaces for mounting external and internal components. Systems and methods are also disclosed for coupling the frame members and corner copulas.

Abstract: A lock assembly is provided for releasably coupling a dome of a telecommunications enclosure to a base of the telecommunications enclosure. The lock assembly generally includes a housing having at least one stop, a slider disposed at least partly within the housing and moveable between an extended position for coupling the dome of the telecommunications enclosure to the base of the telecommunications enclosure and a retracted position for uncoupling the dome from the base, and a cam configured to rotate and move the slider between the retracted position and the extended position. The cam is engageable with the at least one stop of the housing to stop rotation of the cam when the slider moves to the retracted position and/or to stop rotation of the cam when the slider moves to the extended position.

Abstract: According to some aspects of the present disclosure, systems and methods are disclosed for cabinet frames, including frame members coupled together via corner copulas. Frame members may include external and internal channels and surfaces for mounting external and internal components. Systems and methods are also disclosed for coupling the frame members and corner copulas.

Abstract: An assembly includes a first component having a surface and a deformable stake extending from the surface and defining a gap between the surface and the deformable stake, and a second component defining a slot configured to receive the deformable stake for coupling the first component and the second component. In some example embodiments, the gap is surrounded by the surface and the deformable stake. In other example embodiments, a width between legs of the deformable stake is greater than a width of the slot of the second component. In yet other example embodiments, the surface from which the deformable stake extends may be an edge surface.

Abstract: A telecommunications pedestal base includes a first base portion having a wall with a first edge, a second base portion having a wall with a second edge positioned adjacent the first edge, and a hinge coupled to the first base portion and the second base portion. The first base portion is movable about the hinge relative to the second base portion to separate the first edge from the second edge and form an opening between the first edge and the second edge. The opening provides access to an interior of the base. Other example telecommunications pedestal bases, distribution pedestals, and methods of installing telecommunications pedestal bases are also disclosed.

Abstract: Disclosed is a sports camera, which comprises a main control unit, an image processing module, a motion parameter detection display module, a power supply module and a memory. The power supply module is connected with the main control unit and the image processing module. The image processing module comprises a digital signal processor and an image sensor, and the motion parameter detection display module comprises a GPS module and an acceleration sensor. The main control unit is connected with the digital signal processor, the memory, the GPS module and the acceleration sensor, and said digital signal processor is connected with the memory and the image sensor. The sports camera of the present invention can make sure that the image is normal and vertical when playing back the photo or video taken by the camera, thereby improving the image effect and increasing the ease of use of the sports camera.

Abstract: Disclosed is a sports camera, which comprises a main control unit, an image processing module, a motion parameter detection display module, a power supply module and a memory. The power supply module is connected with the main control unit and the image processing module. The image processing module comprises a digital signal processor and an image sensor, and the motion parameter detection display module comprises a GPS module and an acceleration sensor. The main control unit is connected with the digital signal processor, the memory, the GPS module and the acceleration sensor, and said digital signal processor is connected with the memory and the image sensor. The sports camera of the present invention can make sure that the image is normal and vertical when playing back the photo or video taken by the camera, thereby improving the image effect and increasing the ease of use of the sports camera.

Abstract: An outdoor telecommunications equipment enclosure includes a dome, a base for receiving the dome, and a slide lock assembly for coupling the dome to the base. The slide lock assembly includes a housing coupled to one of the dome and the base and defining a channel and a slider positioned within the channel. The slider is moveable between a retracted position and an extended position for engaging the other one of the dome and the base. In one example embodiment, one of the slider and the housing includes multiple protrusions in contact with the other one of the slider and the housing. The protrusions inhibit surface contact between the slider and the housing. In another example embodiment, the slide lock assembly includes a gasket, seal and/or plug to inhibit ingress of debris into the slide lock assembly.

Abstract: A cooling fixture for molded components includes a support surface, at least two brackets coupled to the support surface, and at least one roller having a central axis. The roller is coupled between the brackets for rotating about its central axis and is positioned for contacting a portion of a molded component and rotating about its central axis as necessary to align the molded component and substantially inhibit gouging of the molded component when the molded component is placed in the cooling fixture for cooling. Additional cooling fixtures and related methods are also disclosed.

Abstract: A sealing assembly for sealing a corner of an enclosure is disclosed. The sealing assembly includes a substantially rigid bracket and a flexible seal. The bracket includes a first latch and a second latch. The first and second latches are configured for releasable connection to an enclosure adjacent a corner with the first and second latches on opposing sides of said corner. The bracket is configured to provide a force to couple the flexible seal to a corner of an enclosure when the bracket is attached to said enclosure. The flexible seal includes a first surface for coupling to the corner of the enclosure, and a second surface opposite the first surface. At least a portion of the second surface is configured for contact with the bracket. The flexible seal may include a connector for releasable connection to the bracket.

Abstract: A lock assembly is provided for releasably coupling a dome of a telecommunications enclosure to a base of the telecommunications enclosure. The lock assembly generally includes a housing having at least one stop, a slider disposed at least partly within the housing and moveable between an extended position for coupling the dome of the telecommunications enclosure to the base of the telecommunications enclosure and a retracted position for uncoupling the dome from the base, and a cam configured to rotate and move the slider between the retracted position and the extended position. The cam is engageable with the at least one stop of the housing to stop rotation of the cam when the slider moves to the retracted position and/or to stop rotation of the cam when the slider moves to the extended position.

Abstract: An assembly including a ground bar for coupling to a ground, a conductive contact for electrically connecting a wire to the ground bar, and a switch for selectively disconnecting the conductive contact from the ground bar to thereby selectively disconnect the wire from the ground bar when the wire is electrically connected to the conductive contact. The assembly may include a plurality of conductive contacts and a plurality of switches for selectively disconnecting an associated conductive contact from the ground bar. A method of using an assembly having a ground bar, a conductive contact, and a switch includes electrically connecting a wire to the conductive contact, and actuating the switch to selectively disconnect the conductive contact from the ground bar to thereby selectively disconnect the wire from the ground bar without electrically disconnecting the wire from the conductive contact.

Abstract: A dust cap for a fiber optic connector is disclosed. The fiber optic connector includes a connector body having a first end and second end opposite the first end, and a ferrule positioned at the first end of the connector body. The ferrule holds an optical fiber having an end face. The dust cap includes a housing defining a cavity for receiving the ferrule of the fiber optic connector and a retaining member coupled to the housing. The retaining member is structured to be disposed adjacent to the second end of the connector body when the ferrule is disposed within the cavity to inhibit removal of the fiber optic connector from the dust cap. Additionally, or alternatively, the dust cap may include a mounting member for releasably engaging a support structure.

Abstract: A sealing assembly for sealing a corner of an enclosure is disclosed. The sealing assembly includes a substantially rigid bracket and a flexible seal. The bracket includes a first latch and a second latch. The first and second latches are configured for releasable connection to an enclosure adjacent a corner with the first and second latches on opposing sides of said corner. The bracket is configured to provide a force to couple the flexible seal to a corner of an enclosure when the bracket is attached to said enclosure. The flexible seal includes a first surface for coupling to the corner of the enclosure, and a second surface opposite the first surface. At least a portion of the second surface is configured for contact with the bracket. The flexible seal may include a connector for releasable connection to the bracket.

Abstract: A telecommunications enclosure including a housing is disclosed. A first panel is operatively coupled to the housing for pivotal movement between a first position and a second position. A second panel is operatively coupled to the housing for pivotal movement between a first position and a second position. The telecommunications enclosure includes a lock operable to retain the first panel in the first position when the second panel is in the second position and to retain the second panel in the first position when the first panel is in the second position. The telecommunications enclosure includes at least one fiber optic splitter mounted on the first panel and a termination field mounted on the second panel.

Abstract: A dust cap for a fiber optic connector is disclosed. The fiber optic connector includes a connector body having a first end and second end opposite the first end, and a ferrule positioned at the first end of the connector body. The ferrule holds an optical fiber having an end face. The dust cap includes a housing defining a cavity for receiving the ferrule of the fiber optic connector and a retaining member coupled to the housing. The retaining member is structured to be disposed adjacent to the second end of the connector body when the ferrule is disposed within the cavity to inhibit removal of the fiber optic connector from the dust cap. Additionally, or alternatively, the dust cap may include a mounting member for releasably engaging a support structure.

Abstract: A dust cap for a fiber optic connector is disclosed. The fiber optic connector includes a connector body having a first end and second end and a ferrule positioned at the first end of the connector body. The ferrule holds an optical fiber having an end face. The dust cap includes a housing adapted to engage the first end of the connector body to releasably couple the dust cap to the fiber optic connector and protect the end face of the optical fiber. Additionally, or alternatively, the dust cap may be configured to releasably engage an adjacent dust cap to join at least two dust caps together, and may include one or more mounting members for releasably coupling the dust cap to a support structure to thereby support the dust cap and any fiber optic connector releasably coupled to the dust cap from the support structure.