Abstract: Compositions and methods for treating a retinopathy or inhibiting pathologic neovascularization in a subject are provided herein. In one embodiment, the method includes ablating or inhibiting IDO-dependent vascularizing cells (IDVCs) in the eye of the subject. Various methods of inhibiting or ablating IDVCs are described, including inhibiting IDO1 and/or integrated response nodes.

Abstract: Computer-implemented methods and apparatus for generating prediction markets are described to gauge business uncertainties surrounding a project with an uncertain timeline and/or an uncertain result. Such prediction markets can be used in any industry segment and across business functions, including research and development (R&D), marketing, executive functions and others. Traditional prediction markets, like equity markets, require liquidity for success. By introducing a pari-mutuel prediction input platform, the present invention describes a modified prediction market that elicits more accurate predictions surrounding business decisions.