Patents by Inventor Simon Topell

Simon Topell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scalable process for protein purification
    Patent number: 9657065
    Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: May 23, 2017
    Assignee: Kuros Biosciences AG
    Inventors: Susanne Richter, Simon Topell
  • SCALABLE PROCESS FOR PROTEIN PURIFICATION
    Publication number: 20150315246
    Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 5, 2015
    Applicant: Cytos Biotechnology AG
    Inventors: SUSANNE RICHTER, Simon Topell
  • Scalable Process for Protein Purification
    Publication number: 20120214976
    Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
    Type: Application
    Filed: August 22, 2011
    Publication date: August 23, 2012
    Applicant: Cytos Biotechnology AG
    Inventors: Susanne Richter, Simon Topell
  • Scalable Process for Protein Purification
    Publication number: 20110306113
    Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
    Type: Application
    Filed: December 23, 2010
    Publication date: December 15, 2011
    Applicant: Cytos Biotechnology AG
    Inventors: Susanne RICHTER, Simon Topell
  • Scalable process for protein purification
    Patent number: 7888098
    Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
    Type: Grant
    Filed: June 20, 2006
    Date of Patent: February 15, 2011
    Assignee: Cytos Biotechnology AG
    Inventors: Susanne Richter, Simon Topell
  • Scalable Process for Protein Purification
    Publication number: 20090048433
    Abstract: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
    Type: Application
    Filed: June 20, 2006
    Publication date: February 19, 2009
    Applicant: Cytos Biotechnology AG
    Inventors: Susanne Richter, Simon Topell