Abstract: There is described a vector for treating Dopamine Transporter Deficiency Syndrome, the vector comprising a promoter operably linked to a human SLC6A3 gene, wherein the promoter is selected from a human synapsin 1 promoter, a CAG promoter, a CMV promoter, a CAMKII promoter, a beta-actin promoter, and a human EF1-alpha promoter. Also described are methods and uses involving the vector for treating Dopamine Transporter Deficiency Syndrome.

Abstract: The present invention provides methods for producing polyurethane foam compositions. Such methods include mixing an A-side composition, a B-side composition, and CO2 to provide a foam mixture, wherein at least a portion of the CO2 is added as a separate stream, or is provided dissolved in the B-side composition.

Abstract: The use of a block copolymer of the following structure. Wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a polymer (or copolymer) of ethylene and polymer B is a polymer of monomers selected from vinyl acetate, C1-C9 acrylate esters, acrylic acid and mixtures thereof as an additive in polyethylene or polyethylene terephthalate to improve the adhesion between co-extruded layers of the polyethylene and the polyethylene terephthalate and laminated films derived from such use.

Abstract: The present invention provides methods for producing polyurethane foam compositions. Such methods include mixing an A-side composition, a B-side composition, and CO2 to provide a foam mixture, wherein at least a portion of the CO2 is added as a separate stream, or is provided dissolved in the B-side composition.

Abstract: A content device may select associated content, such as adverts, for a user selected content item based on textual characterizing data for the associated content and the user selected content item. A term set characterizing the user selected content item is expanded using semantic graphs and similarity values between the expanded term set and term sets describing associated content is calculated. A specific associated content item is then selected based on the similarity values. The semantic graph based term set expansion may allow improved accuracy in selecting appropriate associated content while providing a process that is suitable for resource constrained scenarios. In particular, communication resource, memory resource, and computational resource usage may be kept low.

Abstract: A content device may select associated content, such as adverts, for a user selected content item based on textual characterizing data for the associated content and the user selected content item. A term set characterizing the user selected content item is expanded using semantic graphs and similarity values between the expanded term set and term sets describing associated content is calculated. A specific associated content item is then selected based on the similarity values. The semantic graph based term set expansion may allow improved accuracy in selecting appropriate associated content while providing a process that is suitable for resource constrained scenarios. In particular, communication resource, memory resource, and computational resource usage may be kept low.

Abstract: The invention provides materials and methods for modulating adenoviral tropism for hepatocytes and other cell types such as splenocytes. It relates to the findings that hypervariable regions (HVRs) of the viral hexon protein interact with the Gla domain of the blood clotting factor FX as part of the infective process in vivo. The invention provides means to disrupt the interaction between hexon and FX, thus reducing infection of hepatocytes and splenocytes, as well as use of targeting agents comprising the Gla domain or a fragment thereof to direct adenoviral vectors to desired target cell or tissue types.

Abstract: A method and apparatus that selects advertisements and determines constraints for presenting the advertisements to a user on a mobile communication device is disclosed. The method may include receiving context history information for a user from one or more retail companies, constructing a profile for the user using the received context history information, storing the user's profile in a user profile database, receiving advertisements from the one or more retail company, storing the received advertisements in an advertisement database, selecting stored advertisements to be sent to the user based on the user's profile, determining constraints on the selected advertisements based on at least one of location and time, and sending the selected advertisements and the determined constraints to the user's mobile communication device for presentation to the user at a particular location and a particular time based on the determined constraints.

Abstract: A method and system of implementing recorded data for automating interactions which occur across the Internet includes storing data at a central Web server adapted for maintaining a database. Responsive to a program script requesting data, computer program code at the central Web server selectively extracts stored data from the database, manipulates the data in accordance with the request, and supplies the manipulated data in a desired format.

Abstract: A multilayer structure comprising (A) a fabric and (B) a polymeric layer comprising a substantially random interpolymer comprising in polymerized form i) one or more ?-olefin monomers and ii) one or more vinyl or vinylidene aromatic monomers and/or one or more sterically hindered aliphatic or cycloaliphatic vinyl or vinylidene monomers, and optionally iii) other polymerizable ethylenically unsaturated monomer(s); layer (B) being free from a substantial amount of tackifier. The multilayer structure has desirable haptics and surprisingly good drape properties. It is useful in many applications, for example as water-impermeable clothes, tablecloths, tents, water-impermeable covers, curtains, artificial leather or upholstery.

Abstract: The present invention discloses a process for producing a polyurethane product with autocatalytic polyols. These auto-catalytic polyols are based on an initiator of the formula (I): HmA-(CH2)n—N(R)—(CH2)p-AHm where n and p are independently integers from 2 to 6, A at each occurrence is independently oxygen, nitrogen or hydrogen, with the proviso that only one of A can be hydrogen at one time, R is a C1 to C3 alkyl group, m is equal to 0 when A is hydrogen, is 1 when A B is oxygen and is 2 when A is nitrogen; or are polyols which contain an alkyl amine of within the polyol chain or a dialkylylamino group pendant to the polyol chain wherein the polyol chain is obtained by copolymerization of at least one monomer containing an alkyl aziridine or N,N-dialkyl glycidylamine with at least one alkylene oxide. These auto-catalytic polyols are reacted with a polyisocyanate in the presence of other additives and/or auxiliary agents known per se to produce polyurethane products.

Abstract: The present invention discloses a process for producing a polyurethane product with autocatalytic polyols. These auto-catalytic polyols are based on an initiator of the formula (I): HmA-(CH2)n—N(R)-(CH2)p-AHm where n and p are independently integers from 2 to 6, A at each occurrence is independently oxygen, nitrogen or hydrogen, with the proviso that only one of A can be hydrogen at one time, R is a C1 to C3 alkyl group, m is equal to 0 when A is hydrogen, is 1 when A B is oxygen and is 2 when A is nitrogen; or are polyols which contain an alkyl amine of within the polyol chain or a dialkylylamino group pendant to the polyol chain wherein the polyol chain is obtained by copolymerization of at least one monomer containing an alkyl aziridine or N,N-dialkyl glycidylamine with at least one alkylene oxide. These auto-catalytic polyols are reacted with a polyisocyanate in the presence of other additives and/or auxiliary agents known per se to produce polyurethane products.

Abstract: The present invention discloses a process for producing a polyurethane product with autocatalytic polyols. These auto-catalytic polyols are based on an initiator of the formula (I): HmA-(CH2)n—N(R)-(CH2)p-AHm where n and p are independently integers from 2 to 6, A at each occurrence is independently oxygen, nitrogen or hydrogen, with the proviso that only one of A can be hydrogen at one time, R is a C1 to C3 alkyl group, m is equal to 0 when A is hydrogen, is 1 when A B is oxygen and is 2 when A is nitrogen; or are polyols which contain an alkyl amine of within the polyol chain or a dialkylylamino group pendant to the polyol chain wherein the polyol chain is obtained by copolymerization of at least one monomer containing an alkyl aziridine or N,N-dialkyl glycidylamine with at least one alkylene oxide. These auto-catalytic polyols are reacted with a polyisocyanate in the presence of other additives and/or auxiliary agents known per se to produce polyurethane products.

Abstract: A method and system for integrating an application executing on a backend system with a mobile device that communicates over a network with the application. The integration includes retrieving from a storage area a method corresponding to a function in the application on the backend system, invoking the method corresponding to the function in the application and creating an interface to the application on the backend system. Information received from the application corresponds to the information requested by the mobile device. This information from the application is transformed to a format suitable for presentation on a mobile device by a presentation server and assisted by a hierarchical universal device library description of mobile devices and browsers.

Abstract: Disclosed is a water-blown methylene diphenylisocyanate-based polyurethane foam for use in packaging of shock or vibration sensitive goods, and a process for its manufacture from a particular polyol composition. The polyurethane foam exhibits a broad shock/vibration attenuation profile rendering it especially suitable for packaging of light weight articles.

Abstract: Disclosed is a water-blown methylene diphenylisocyanate-based polyurethane foam for use in packaging of shock or vibration sensitive goods, and a process for its manufacture from a particular polyol composition. The polyurethane foam exhibits a broad shock/vibration attenuation profile rendering it especially suitable for packaging of light weight articles.