Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: A method may receive a query. A method may obtain a representation of the query, the representation approximating content of the query. A method may determine a set of files accessible by an operating system that are relevant to the query by comparing the representation of the query with representations of files stored in an index, the files in the set of files having representations meeting a similarity threshold with the representation of the query. A method may cause a display of a response to the query, the response identifying the files in the set of files as relevant to the query.

Abstract: A video encoder is configured to encode, by block based predictive encoding, pictures of a video into coding data, wherein the block based predictive encoding includes an intra-picture prediction. The video encoder is configured to use, for the intra-picture prediction, for encoding a prediction block of a picture, a plurality of nearest reference samples of the picture directly neighboring the prediction block and a plurality of extended reference samples, each extended reference sample of the plurality of extended reference samples separated from the prediction block at least by one nearest reference sample of the plurality of reference samples. The video encoder is further configured to sequentially determine an availability or unavailability of each of the plurality of nearest reference samples and to substitute a nearest reference sample being determined as unavailable by a substitution sample. The video encoder is configured to use the substitution sample for the intra-picture prediction.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R3, R4a, R4b, R4c, R4d, R4f, X1, X2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R4f, R5, R6 have the meaning as indicated in the description and claims The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: Substituted N-phenylacetamide compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases.

Abstract: A video encoder is configured to encode, by block based predictive encoding, pictures of a video into coding data, wherein the block based predictive encoding includes an intra-picture prediction. The video encoder is configured to use, for the intra-picture prediction, for encoding a prediction block of a picture, a plurality of nearest reference samples of the picture directly neighboring the prediction block and a plurality of extended reference samples, each extended reference sample of the plurality of extended reference samples separated from the prediction block at least by one nearest reference sample of the plurality of reference samples. The video encoder is further configured to sequentially determine an availability or unavailability of each of the plurality of nearest reference samples and to substitute a nearest reference sample being determined as unavailable by a substitution sample. The video encoder is configured to use the substitution sample for the intra-picture prediction.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra4, Ra5, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: A video encoder is configured to encode, by block based predictive encoding, pictures of a video into coding data, wherein the block based predictive encoding includes an intra-picture prediction. The video encoder is configured to use, for the intra-picture prediction, for encoding a prediction block of a picture, a plurality of nearest reference samples of the picture directly neighboring the prediction block and a plurality of extended reference samples, each extended reference sample of the plurality of extended reference samples separated from the prediction block at least by one nearest reference sample of the plurality of reference samples. The video encoder is further configured to sequentially determine an availability or unavailability of each of the plurality of nearest reference samples and to substitute a nearest reference sample being determined as unavailable by a substitution sample. The video encoder is configured to use the substitution sample for the intra-picture prediction.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1 to R3, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing one or more diseases or disorders associated with integrated stress response.

Abstract: A video encoder is configured to encode, by block based predictive encoding, pictures of a video into coding data, wherein the block based predictive encoding includes an intra-picture prediction. The video encoder is configured to use, for the intra-picture prediction, for encoding a prediction block of a picture, a plurality of nearest reference samples of the picture directly neighboring the prediction block and a plurality of extended reference samples, each extended reference sample of the plurality of extended reference samples separated from the prediction block at least by one nearest reference sample of the plurality of reference samples. The video encoder is further configured to sequentially determine an availability or unavailability of each of the plurality of nearest reference samples and to substitute a nearest reference sample being determined as unavailable by a substitution sample. The video encoder is configured to use the substitution sample for the intra-picture prediction.

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: SILP catalyst for the hydroformylation of olefins with synthesis gas, wherein the catalyst comprises at least one spherical catalyst pellet of radius R, characterized in that the catalyst complies with the following SILP modulus: c i c i , S = R x ? sinh ? ( ? SILP ? x R ) sinh ? ( ? SILP ) where ?SILP is a dimensionless number in respect of the spherical catalyst pellet relating the mass transfer, in the pore, across the phase interface between gas and ionic liquid and in the ionic liquid to the reaction, where ci is the concentration of a component i and ci,S is the concentration of a component i at the surface of the SILP catalyst pellet, and x is the position. Also featured is a process for hydroformylation of olefins with synthesis gas by using the SILP catalyst.

Abstract: A composition and the use of said composition as catalytically active composition in processes for synthesis of chemical compounds, especially the hydroformylation of olefinically unsaturated hydrocarbon mixtures.

Abstract: In order to provide a product that is suitable as fat substitute in foods, which can be produced simply and inexpensively and is deemed safe from the nutritional physiology viewpoint and with which the typical texture of fat-containing foods can be simulated as favorably as possible, particles of collagen material are proposed which are substantially insoluble and swellable in water, wherein in swollen state the particles have an average diameter of less than approximately 150 ?m. A process for the production of this product is additionally proposed.

Abstract: The present invention relates to a sugar confectionary product on the basis of a gelatin gel, comprising approximately 1% to approximately 15% by weight of gelatin, and approximately 20% to approximately 85% by weight of at least one sugar and/or sugar substitute. In order to increase the melting point of the gelatin gel, it is proposed that the sugar confectionary product contains one or more polyphenols.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.