Abstract: There is provided a method of culturing cells, wherein the method comprises: placing a substrate in a bioreactor, wherein the substrate is in the form of a rolled-up film; culturing cells on the substrate in the biore-actor; and optionally, removing the substrate from the bioreactor; wherein the substrate is processed using roll-to-roll processing and, as part of the roll-to-roll processing, at least one of the following steps occur: a plurality of channels are introduced into the substrate; a surface roughness of the substrate is increased; a coating is applied to the substrate; the substrate is subjected to a surface treatment step; cultured cells are removed from the substrate. Also provided is a bioreactor system for culturing cells comprising a substrate within the bioreactor, wherein the substrate is in the form of a rolled-up film and the rolled-up film has a plurality of channels.

Abstract: There is provided a method of culturing cells, wherein the method comprises: introducing seed cells onto a first surface of a first substrate; culturing cells on the first surface of the first substrate within a bioreactor, wherein culture medium is introduced over a second surface of the first substrate and permeates through the substrate to the first surface; wherein the second surface is on the opposite side of the substrate to the first surface. Also provided is a bioreactor system comprising a bioreactor; a first substrate within the bioreactor, wherein the first substrate has a first surface and a second surface, wherein the second surface is on the opposite side of the first substrate to the first surface, and the first surface is in fluid communication with the second surface; wherein the bioreactor is configured to introduce cell culture medium to the second surface of the first substrate.

Abstract: There is provided a method of culturing cells, the method comprising: obtaining a substrate assembly, the substrate assembly comprising: (i) a plurality of fibres, wherein each fibre has an internal channel running along its length; (ii) a first support at a first end of the plurality of fibres; (iii) a second support at a second end of the plurality of fibres; wherein at least one of the first support and the second support allows fluid communication across the support into the internal channels while preventing fluid communication across the support to the external surfaces of the plurality of fibres; introducing a first type of cells into the internal channels of the plurality of fibres; introducing a second type of cells onto the external surfaces of the plurality of fibres; and culturing cells on the substrate assembly in a bioreactor. Also provided is a substrate assembly for culturing cells.

Abstract: A method of texturizing a casting mold of a continuous belt casting system includes providing at least one endless belt having an elongated belt surface. The elongated belt surface includes at least a first region and at least a second region adjacent to the first region across a width of the elongated belt surface, and the elongated belt surface is configured to at least partially define a casting cavity of the continuous belt casting system. The method includes texturizing the elongated belt surface by applying a predetermined texture to the first region.

Abstract: Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.

Abstract: A continuous casting and rolling line for casting, rolling, and otherwise preparing metal strip can produce distributable metal strip without requiring cold rolling or the use of a solution heat treatment line. A metal strip can be continuously cast from a continuous casting device and coiled into a metal coil, optionally after being subjected to post-casting quenching. This intermediate coil can be stored until ready for hot rolling. The as-cast metal strip can undergo reheating prior to hot rolling, either during coil storage or immediately prior to hot rolling. The heated metal strip can be cooled to a rolling temperature and hot rolled through one or more roll stands. The rolled metal strip can optionally be reheated and quenched prior to coiling for delivery. This final coiled metal strip can be of the desired gauge and have the desired physical characteristics for distribution to a manufacturing facility.

Abstract: There is provided a substrate assembly for culturing cells, wherein the substrate assembly comprises: a plurality of edible fibres, wherein each fibre has an internal channel running along its length; a first support at a first end of the plurality of edible fibres; a second support at a second end of the plurality of edible fibres; wherein at least one of the first support and second support allows fluid communication across the support into the internal channels. Also provided is a method of culturing cells.

Abstract: A cooling pad for a belt casting system includes a first nozzle arrangement and a second nozzle arrangement. In some embodiments, the first nozzle arrangement includes an elongated nozzle assembly that includes a base defining a receiving area, a first insert positionable within the receiving area, and a second insert positionable within the receiving area. The first insert and the base together define a first elongated dispensing slot. The second insert is adjustable relative to the first insert, and the second insert and the base together define a second elongated dispensing slot. In various embodiments, the second nozzle arrangement includes a plurality of multi-position nozzles, each movable between a base position and an offset position such that the heat transfer rate may be locally controlled across the cooling cavity.

Abstract: A beverage system is provided. An adaptor assembly can be used with the beverage system and include a brew basket defining a cavity therein and having a fluid outlet. The assembly also includes a pod adapter and a filter adaptor receivable within the cavity in the brew basket. The pod adapter has at least one engagement feature arranged to be received within at least one corresponding slot in the brew basket. The filter adaptor includes a showerhead coupled to the filter body, the showerhead being arranged to receive fluid through an opening therein and to distribute fluid into the filter body. An internal storage cavity can be arranged within the housing of the beverage system for storing the adaptors. Additionally, a flow path cover can be positioned on the beverage system and configured to prevent unintentional water discharge from a brew chamber.

Abstract: A beverage system is provided. An adaptor assembly can be used with the beverage system and include a brew basket defining a cavity therein and having a fluid outlet. The assembly also includes a pod adapter and a filter adaptor receivable within the cavity in the brew basket. The pod adapter has at least one engagement feature arranged to be received within at least one corresponding slot in the brew basket. The filter adaptor includes a showerhead coupled to the filter body, the showerhead being arranged to receive fluid through an opening therein and to distribute fluid into the filter body. An internal storage cavity can be arranged within the housing of the beverage system for storing the adaptors. Additionally, a flow path cover can be positioned on the beverage system and configured to prevent unintentional water discharge from a brew chamber.

Abstract: A cooling pad for a belt casting system includes a first nozzle arrangement and a second nozzle arrangement. In some embodiments, the first nozzle arrangement includes an elongated nozzle assembly that includes a base defining a receiving area, a first insert positionable within the receiving area, and a second insert positionable within the receiving area. The first insert and the base together define a first elongated dispensing slot. The second insert is adjustable relative to the first insert, and the second insert and the base together define a second elongated dispensing slot. In various embodiments, the second nozzle arrangement includes a plurality of multi-position nozzles, each movable between a base position and an offset position such that the heat transfer rate may be locally controlled across the cooling cavity.

Abstract: Provided herein are continuously cast aluminum alloy products exhibiting uniform surface characteristics. The aluminum alloy products have a first surface comprising a width, wherein the first surface comprises an average of 50 exudates or less per square centimeter across the width of the first surface. Also provided herein are methods of making aluminum alloy products having improved surface characteristics. Further provided are methods and systems for manufacturing aluminum alloy products, such as sheets, having reduced surface defects.

Abstract: A dynamic hybrid residential threat detection method is disclosed. The method includes receiving, by a packet selector on a customer premises equipment (CPE), communication sessions and selecting and sending, by the packet selector, a predefined number of packets of the communication sessions to a CPE detection engine based on packet selection rules. The method also includes inspecting, by the CPE detection engine, the predefined number of packets of each communication session based on CPE detection rules that establish what type of inspection is to be performed by the CPE detection engine based at least in part on CPE resource constraints. The method further includes sending, by the packet selector, the predefined number of packets of at least some of the communication sessions to a cloud detection engine and blocking particular communication traffic on the CPE based on the inspection and/or an instruction from the cloud detection engine.

Abstract: A dynamic cloud-based threat detection system is disclosed. The system comprises a network broker that receives communication sessions associated with communication device(s) via a network and selects and sends a predefined number of packets of each communication session to a detection based on packet selection rules. The communication device(s) comprises customer premises equipment (CPE) and/or a mobile communication device. The detection engine receives and inspects the predefined number of packets of each communication session and a governor that initiates blocking of particular communication traffic based on the inspection. The system also comprises a dynamic optimizer that monitors factor(s) and creates and sends updated packet rules to the network broker based on the monitoring. The network broker selects and sends a different predefined number of packets of each of a second plurality of communication sessions to the detection engine for inspection based on the updated packet selection rules.

Abstract: Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.

Abstract: A method of dynamic residential threat detection is disclosed. The method includes a packet selection component on a customer premises equipment (CPE) sending a predefined number of packets of each of a plurality of communication sessions to a detection engine based on packet selection rules. The method also includes the detection engine on the CPE receiving and inspecting the predefined number of packets. The method further includes a dynamic optimizing component on the CPE monitoring one or more factors and creating and sending updated packet selection rules based on the monitored factor(s) to the packet selection component. The method additionally comprises the packet selection component sending a different predefined number of packets of each of a second plurality of communication sessions to the detection engine based on the updated packet selection rules. The method further includes the detection engine receiving and inspecting the different predefined number of packets.

Abstract: Virtual clothing systems and methods are disclosed which comprise receiving a display request for displaying virtual clothing worn by a virtual body model. The request includes a reference to a set of clothing models. The system and method further comprises generating a set of animated composite models. Each animated composite model includes a body model, one of the referenced set of clothing models and a motion descriptor. In response to the display request, user interface data is transmitted to a user device. A user interface on the user device is configured by the user interface data to display renders of the animated composite models.

Abstract: Described are nosetips for continuous casting of a metal alloy. The nosetip may include a first portion having a first surface parallel to a second surface opposite the first surface. The nosetip may include a second portion having a third surface directed toward an extended first surface. The extended first surface may be in a common plane with the first surface. The nosetip may include a third portion having an arcuate surface connecting the third surface to the extended first surface. The arcuate surface may include a point of curvature at a vertical distance from the extended first surface. The vertical distance may be configured to limit a maximum meniscus height for liquid metal, cast using the nosetip, between the nosetip and a continuous casting surface. Also described are methods of continuous casting a metal alloy at a casting speed of greater than 12 m/min.

Abstract: Provided herein are continuously cast aluminum alloy products exhibiting uniform surface characteristics. The aluminum alloy products have a first surface comprising a width, wherein the first surface comprises an average of 50 exudates or less per square centimeter across the width of the first surface. Also provided herein are methods of making aluminum alloy products having improved surface characteristics. Further provided are methods and systems for manufacturing aluminum alloy products, such as sheets, having reduced surface defects.

Abstract: An solid oxide fuel cell stack having a metallic layer and a glass layer, and a method for preventing or reducing a chemical reaction between a metallic layer and a glass layer are disclosed. The solid oxide fuel cell stack has a barrier layer disposed between the metallic layer and the glass layer. The barrier layer includes alumina and a phosphate. The phosphate includes an aluminum dihydrogen phosphate, an aluminum-containing phosphate, a phosphate of an element of the metallic layer, a phosphate of an element of the glass layer, or combinations thereof. The method includes disposing a barrier layer between the metallic layer and the glass layer.