Patents by Inventor Simon Ye
Simon Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20250090688Abstract: Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In son embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.Type: ApplicationFiled: August 5, 2022Publication date: March 20, 2025Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
-
Publication number: 20250051800Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.Type: ApplicationFiled: October 15, 2024Publication date: February 13, 2025Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
-
Publication number: 20250043309Abstract: Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.Type: ApplicationFiled: October 15, 2024Publication date: February 6, 2025Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye, Kim Lagerborg, Alexandra Stanton, Amy Wagers
-
Publication number: 20250002541Abstract: Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of a n-mer insert containing or being composed only of a P-motif. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.Type: ApplicationFiled: September 8, 2022Publication date: January 2, 2025Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye, Alexandra Stanton, Kim Lagerborg
-
Publication number: 20240424143Abstract: Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of one or more n-mer inserts, that can include one or more RGD motifs, and/or one or more P-motifs. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.Type: ApplicationFiled: September 8, 2022Publication date: December 26, 2024Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
-
Publication number: 20240409956Abstract: Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of one or more n-mer inserts, that can include one or more RGD motifs, and/or one or more P-motifs. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.Type: ApplicationFiled: October 5, 2022Publication date: December 12, 2024Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
-
Patent number: 11920150Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.Type: GrantFiled: March 29, 2022Date of Patent: March 5, 2024Assignees: The Broad Institute, Inc., President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
-
Publication number: 20230193316Abstract: Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of a n-mer motif, P motif, or both. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.Type: ApplicationFiled: April 30, 2021Publication date: June 22, 2023Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
-
Publication number: 20230159949Abstract: Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.Type: ApplicationFiled: July 22, 2021Publication date: May 25, 2023Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE, Kim LAGERBORG, Alexandra STANTON, Amy WAGERS
-
Publication number: 20220340929Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.Type: ApplicationFiled: October 16, 2020Publication date: October 27, 2022Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
-
Patent number: 11479638Abstract: Disclosed herein are compounds of formulas (I) and (II), Wherein R1, R2, R3 and (1) are as described herein. Methods of making compounds of formulas (I) and (II), curable compositions containing them and cured compositions containing them are also described. The compounds of formulas (I) and II are curing agents, fire retardants or both.Type: GrantFiled: November 9, 2017Date of Patent: October 25, 2022Assignee: Blue Cube IP LLCInventor: Simon Ye
-
Publication number: 20220325296Abstract: Described herein are methods of generating engineered viral capsid variants. Also described herein are engineered viral capsid variants, engineered viral particles and formulations and cells thereof. Also described herein are vector systems containing an engineered viral capsid polynucleotide and uses thereof.Type: ApplicationFiled: September 11, 2020Publication date: October 13, 2022Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
-
Publication number: 20220257677Abstract: Described herein are methods of generating engineered viral capsid variants. Also described herein are engineered viral capsid variants, engineered viral particles and formulations and cells thereof. Also described herein are vector systems containing an engineered viral capsid polynucleotide and uses thereof.Type: ApplicationFiled: March 30, 2022Publication date: August 18, 2022Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
-
Publication number: 20220243226Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.Type: ApplicationFiled: March 29, 2022Publication date: August 4, 2022Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
-
Publication number: 20220228173Abstract: Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.Type: ApplicationFiled: March 29, 2022Publication date: July 21, 2022Inventors: Pardis SABETI, Mohammadsharif Tabebordbar, Simon Ye, Kim Lagerborg, Alexandra Stanton, Amy Wagers
-
Publication number: 20200291172Abstract: Disclosed herein are compounds of formulas (I) and (II), Wherein R1, R2, R3 and (1) are as described herein. Methods of making compounds of formulas (I) and (II), curable compositions containing them and cured compositions containing them are also described. The compounds of formulas (I) and II are curing agents, fire retardants or both.Type: ApplicationFiled: November 9, 2017Publication date: September 17, 2020Inventor: Simon Ye
-
Patent number: 9822214Abstract: Embodiments include curable compositions including an epoxy resin and a hardener component including a polymer having first constitutional unit, a second constitutional unit, and a third constitutional unit, where the epoxy group to the second constitutional unit has a molar ratio in a range of 0.5:1 to 5:1. Embodiments include prepregs that include a reinforcement component and the curable composition and an electrical laminate formed with the curable composition.Type: GrantFiled: July 24, 2014Date of Patent: November 21, 2017Assignee: BLUE CUBE IP LLCInventors: Simon Ye, Tianhui Xiao, Hongyu Chen, Michael J. Mullins, Yu Cai, Jiawen Xiong, Joey W. Storer, Mark B. Wilson, Frank Y. Gong
-
Publication number: 20160194438Abstract: Embodiments include curable compositions including an epoxy resin and a hardener component including a polymer having first constitutional unit, a second constitutional unit, and a third constitutional unit, where the epoxy group to the second constitutional unit has a molar ratio in a range of 0.5:1 to 5:1. Embodiments include prepregs that include a reinforcement component and the curable composition and an electrical laminate formed with the curable composition.Type: ApplicationFiled: July 24, 2014Publication date: July 7, 2016Inventors: Simon Ye, Tianhui Xiao, Hongyu Chen, Michael J. Mullins, Yu Cai, Jiawen Xiong, Joey W. Storer, Mark B. Wilson, Frank Y. Gong