Patents by Inventor Simon Ye

Simon Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11920150
    Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: March 5, 2024
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
  • Publication number: 20230193316
    Abstract: Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of a n-mer motif, P motif, or both. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.
    Type: Application
    Filed: April 30, 2021
    Publication date: June 22, 2023
    Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
  • Publication number: 20230159949
    Abstract: Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.
    Type: Application
    Filed: July 22, 2021
    Publication date: May 25, 2023
    Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE, Kim LAGERBORG, Alexandra STANTON, Amy WAGERS
  • Publication number: 20220340929
    Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
    Type: Application
    Filed: October 16, 2020
    Publication date: October 27, 2022
    Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
  • Patent number: 11479638
    Abstract: Disclosed herein are compounds of formulas (I) and (II), Wherein R1, R2, R3 and (1) are as described herein. Methods of making compounds of formulas (I) and (II), curable compositions containing them and cured compositions containing them are also described. The compounds of formulas (I) and II are curing agents, fire retardants or both.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: October 25, 2022
    Assignee: Blue Cube IP LLC
    Inventor: Simon Ye
  • Publication number: 20220325296
    Abstract: Described herein are methods of generating engineered viral capsid variants. Also described herein are engineered viral capsid variants, engineered viral particles and formulations and cells thereof. Also described herein are vector systems containing an engineered viral capsid polynucleotide and uses thereof.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 13, 2022
    Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
  • Publication number: 20220257677
    Abstract: Described herein are methods of generating engineered viral capsid variants. Also described herein are engineered viral capsid variants, engineered viral particles and formulations and cells thereof. Also described herein are vector systems containing an engineered viral capsid polynucleotide and uses thereof.
    Type: Application
    Filed: March 30, 2022
    Publication date: August 18, 2022
    Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
  • Publication number: 20220243226
    Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
    Type: Application
    Filed: March 29, 2022
    Publication date: August 4, 2022
    Inventors: Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE
  • Publication number: 20220228173
    Abstract: Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 21, 2022
    Inventors: Pardis SABETI, Mohammadsharif Tabebordbar, Simon Ye, Kim Lagerborg, Alexandra Stanton, Amy Wagers
  • Publication number: 20200291172
    Abstract: Disclosed herein are compounds of formulas (I) and (II), Wherein R1, R2, R3 and (1) are as described herein. Methods of making compounds of formulas (I) and (II), curable compositions containing them and cured compositions containing them are also described. The compounds of formulas (I) and II are curing agents, fire retardants or both.
    Type: Application
    Filed: November 9, 2017
    Publication date: September 17, 2020
    Inventor: Simon Ye
  • Patent number: 9822214
    Abstract: Embodiments include curable compositions including an epoxy resin and a hardener component including a polymer having first constitutional unit, a second constitutional unit, and a third constitutional unit, where the epoxy group to the second constitutional unit has a molar ratio in a range of 0.5:1 to 5:1. Embodiments include prepregs that include a reinforcement component and the curable composition and an electrical laminate formed with the curable composition.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: November 21, 2017
    Assignee: BLUE CUBE IP LLC
    Inventors: Simon Ye, Tianhui Xiao, Hongyu Chen, Michael J. Mullins, Yu Cai, Jiawen Xiong, Joey W. Storer, Mark B. Wilson, Frank Y. Gong
  • Publication number: 20160194438
    Abstract: Embodiments include curable compositions including an epoxy resin and a hardener component including a polymer having first constitutional unit, a second constitutional unit, and a third constitutional unit, where the epoxy group to the second constitutional unit has a molar ratio in a range of 0.5:1 to 5:1. Embodiments include prepregs that include a reinforcement component and the curable composition and an electrical laminate formed with the curable composition.
    Type: Application
    Filed: July 24, 2014
    Publication date: July 7, 2016
    Inventors: Simon Ye, Tianhui Xiao, Hongyu Chen, Michael J. Mullins, Yu Cai, Jiawen Xiong, Joey W. Storer, Mark B. Wilson, Frank Y. Gong