Abstract: Described are methods, systems, and media for regulatory exploration comprising: receiving a regulatory exploration request comprising a scenario comprising a desired outcome and a plurality of partial inputs to describe the scenario and identify fact constraints; receiving an executable regulatory logic flow chart, wherein each element of the flow chart is associated with a regulatory text; applying algorithm to determine all paths in the regulatory logic flow chart; filtering the paths based on the desired outcome; transforming each remaining path into a logical expression comprising attributes; generating a query space comprising conditions on the input facts associated with each attribute; generating a fact space comprising input facts associated with each attribute; generating a possibility space by joining the input facts in the fact space under the conditions in the query space; converting the possibility space to a plurality of database queries; and running the queries to generate an output.

Abstract: Described are techniques for grouping user profiles onto Virtual Private Networks (VPNs) including a computer-implemented method comprising creating a user profile at a VPN manager and associating the user profile with a set of demographically similar user profiles based on characteristics of the user profile. The computer-implemented method further comprises assigning the user profile to least one VPN server that is associated with the set of demographically similar user profiles. The computer-implemented method further comprises providing encrypted internet access to a device associated with the user profile via the at least on VPN server. The computer-implemented method further comprises transmitting resources to the device associated with the user profile via the at least one VPN server, where the resources are customized for the set of demographically similar user profiles.

Abstract: The disclosure generally describes methods, software, and systems for cross-application protocols describing integration dependencies. A request is received to synchronize customer data from multiple system instances. The system instances include one or more application programming interfaces. A semantic description of an integration process configured to synchronize the customer data from the plurality of system instances is generated. The semantic description defines integration dependencies between system instances. The integration process is executed to synchronize the customer data from the plurality of system instances to generate synchronized customer data. The synchronized customer data are provided for storage.

Abstract: The present invention relates to immune stimulating micelle compositions, and their use in treatment of diseases and disorders, such as cancer. In particular, the present invention relates to micelle compositions comprising a TLR7 agonist, such as 1V270.

Abstract: A radiation detector uses a direct conversion layer (30) with first and second readout sensors (20, 24) located on opposite sides of the direct conversion layer (30). A biasing arrangement provides a voltage bias across the direct conversion layer (30) using pixel electrodes (22, 26) of the first and second readout sensors. The use of a direct conversion layer (30) gives an intrinsic high spatial resolution and enables X-ray photon counting. Two independent readout sensors (e.g. with different technologies and related back-end electronics) are thereby combined in one detector without compromising their functionality. The detector can be made at low cost, by virtue of the use of a single direct conversion layer (30) which is coupled on both sides to multiple readout sensors.

Abstract: A computer-implemented method/system/instructions of automatic margin line proposal includes receiving a 3D digital model of at least a portion of a jaw, the 3D digital model including a digital preparation tooth; determining, using a first trained neural network, an inner representation of the 3D digital model; and determining, using a second trained neural network, a margin line proposal from a base margin line and the inner representation of the 3D digital model.

Abstract: A rotor for a drive motor having a rotor core on the outer circumference of which a surface magnet is arranged, wherein a reinforcing sleeve is arranged on an outer circumference of the surface magnet for fixing the surface magnet to the rotor core.

Abstract: In order to create a bipolar plate for an electrochemical unit of an electrochemical device comprising a plurality of electrochemical units that follow one another along a stack direction, wherein the bipolar plate comprises the following: at least one medium passage opening, which forms a constituent part of a medium channel that extends along the stack direction through the electrochemical device; a sealing bead, which extends around the medium passage opening; a plurality of medium inlets, which are arranged on an inner side of the sealing bead facing toward the medium passage opening and which enable medium to flow into an interior space of the sealing bead; and a plurality of medium outlets, which are arranged on an outer side of the sealing bead facing away from the medium passage opening and which enable medium to flow out of the interior space of the sealing bead, in which bipolar plate the pressure loss that occurs when the medium flows from the medium passage opening through the medium inlets, t

Abstract: Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.

Abstract: A device for acoustic detection of an electric arc, including a tubular probe suitable for being arranged next to a piece of electrical equipment on which an electric arc is likely to form. An interior space, circumscribed by a wall of the probe, extends along the length of the probe. This interior space is filled with a fluid and acoustically isolated from external noise by the wall. The probe includes, at the periphery of its interior space, on its wall, at least one vulnerable zone suitable for degrading under the effect of the electric arc, revealing a passage to the interior space for an acoustic wave generated by the electric arc. The device further includes at least one acoustic sensor suitable for detecting the acoustic wave that travelled through the passage and propagated in the interior space of the probe.

Abstract: A multi-agent computerized simulation system for training a user to operate a vehicle comprises an interactive computerized simulation station having tangible instrumentation enabling the user to control a simulated vehicle in a multi-agent simulation, a memory storing simulation data for the multi-agent simulation, and a processor configured to execute the multi-agent simulation. The simulation provides a simulated traffic controller having a traffic controller artificial intelligence that interacts verbally with the user to coordinate movement of the simulated vehicle. The simulation also provides one or more simulated external vehicles that simulate one or more external vehicles whose movement is scripted deterministically in the simulation. Alternatively, each simulated external vehicle is operated by an autonomous agent having AI controlling the simulated external vehicle by making observations and decisions and by reacting to verbal instructions received by the simulated traffic controller.

Abstract: A high-electron-mobility transistor comprises a semiconductor body comprising a barrier region and a channel region that forms a heterojunction with the barrier region such that a two-dimensional charge carrier gas channel is disposed in the channel region, source and drain electrodes disposed on the semiconductor body and laterally spaced apart from one another, a gate structure disposed on the semiconductor body and laterally between the source and drain electrodes, the gate structure being configured to control a conduction state of two-dimensional charge carrier gas, and a first dielectric region that is disposed along the upper surface of the semiconductor body in a lateral region that is between the gate structure and the drain electrode, wherein the first dielectric region comprises aluminum and oxide, and wherein first dielectric region comprises a first end that faces and is laterally spaced apart from the gate structure.

Abstract: The present invention relates to a polyomaviral gene delivery vector particle comprising a nucleic acid sequence encoding a phosphatase activity-possessing polypeptide. In particular the present invention relates to a polyomaviral gene delivery vector particle comprising a nucleic acid sequence encoding an alkaline phosphatase activity-possessing polypeptide, and/or further comprising a nucleic acid sequence encoding a growth factor protein, such as insulin and/or insulin-like growth factor or precursors thereof. The present invention further relates to a polyomaviral gene delivery vector particle according to the present invention for use in a method of treatment by removal or inactivation of damage-associated molecular patterns at the site of the inflammation in a subject and a composition comprising the polyomaviral gene delivery vector particle of the present invention.

Abstract: A method for manufacturing a SiC-based electronic device, comprising the steps of: implanting, on a front side of a solid body made of SiC having a conductivity of an N type, dopant species of a P type thus forming an implanted region, which extends in the solid body starting from the front side and has a top surface coplanar with the front side; and generating a laser beam directed towards the implanted region in order to generate heating of the implanted region to temperatures comprised between 1500° C. and 2600° C. so as to form a carbon-rich electrical-contact region at the implanted region. The carbon-rich electrical-contact region forms an ohmic contact.

Abstract: The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

Abstract: Described herein is a complex comprising multiple nucleic acid molecules that are hybridized together, each comprising, from 5? to 3?, a first complementary sequence, a spacer sequence and a second complementary sequence, and either/or a 5? end sequence that is 5? of the first complementary sequence and terminates in a 5? phosphate and a 3? end sequence that is 3? of the second complementary sequence and terminates in a 3? hydroxyl. In this complex: the first complementary sequence of one molecule is directly or indirectly hybridized with the second complementary sequence of another molecule in the complex and the spacer sequence and the 3? and/or 5? end sequences are single-stranded. Methods of making and using the complex are also provided.

Abstract: Grinding apparatus including a hopper provided with feed means, the hopper being configured to contain and feed the beans, a grinding device configured to grind the beans, and weighing means for weighing the beans.

Abstract: The present invention relates to CAR cell composition for use in treating hematological malignancies in a subject in need thereof, wherein said CAR cell is an immune cell which expresses a chimeric antigen receptor molecule that binds a cancer-related antigen, and wherein a therapeutically effective amount of CAR cell composition is administered in combination with a therapeutically effective amount of an S1P receptor modulator or a pharmaceutically acceptable salt thereof or a phosphate derivative thereof.

Abstract: Systems and methods for a self-adjusting vehicle mirror. The mirror automatically locates the face of the driver or another passenger, and orients the mirror to provide the driver/passenger face with a desired view from the mirror. The mirror may continue to reorient itself as the driver or passenger shifts position, to continuously provide a desired field of view even as he or she changes position over time. In certain embodiments, the mirror system of the disclosure can be a self-contained system, with the mirror, mirror actuator, camera, and computing device all contained within the mirror housing as a single integrated unit.