Patents by Inventor Simona Daniele

Simona Daniele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF
    Publication number: 20200299306
    Abstract: Disclosed are compounds of general formula (I), and their use for the treatment and diagnosis of degenerative disorders characterized by high cell proliferation and/or tissue degeneration.
    Type: Application
    Filed: September 4, 2018
    Publication date: September 24, 2020
    Inventors: Armando ROSSELLO, Elisa NUTI, Elisabetta ORLANDINI, Susanna NENCETTI, Claudia MARTINI, Barbara COSTA, Chiara GIACOMELLI, Simona DANIELE
  • 2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1
    Patent number: 10351548
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumors such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 16, 2019
    Assignee: International Society for Drug Development S.R.L.
    Inventors: Simona Sestito, Simona Daniele, Claudia Martini, Simona Rapposelli, Guido Puricelli
  • 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA
    Publication number: 20190160049
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) in the treatment of pathologies which require a dual inhibitor of PDK1/AurA enzymes such as for instance tumours, particularly glioblastoma.
    Type: Application
    Filed: June 8, 2017
    Publication date: May 30, 2019
    Inventors: Simona SESTITO, Simona DANIELE, Claudia MARTINI, Simona RAPPOSELLI, Guido PURICELLI
  • 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1
    Publication number: 20180155320
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumours such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 7, 2018
    Inventors: Simona SESTITO, Simona DANIELE, Claudia MARTINI, Simona RAPPOSELLI, Guido PURICELLI
  • GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF
    Publication number: 20150094348
    Abstract: Disclosed are compounds able to modulate the activity of the GPR17 receptor in a highly specific way, which are useful in the treatment and diagnosis of diseases or dysfunctions involving the activation of said receptor. In particular, the compounds according to the invention can be used for neuroprotective and/or reparatory purposes, in cerebral, cardiac and renal ischaemia, in cerebral trauma, in chronic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), and in demyelinating diseases such as multiple sclerosis.
    Type: Application
    Filed: November 28, 2014
    Publication date: April 2, 2015
    Inventors: Mariapia Abbracchio, Ivano Eberini, Chiara Parravicini, Claudia Martini, Maria Letizia Trincavelli, Simona Daniele
  • GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF
    Publication number: 20140148472
    Abstract: Disclosed are compounds able to modulate the activity of the GPR17 receptor in a highly specific way, which are useful in the treatment and diagnosis of diseases or dysfunctions involving the activation of said receptor. In particular, the compounds according to the invention can be used for neuroprotective and/or reparatory purposes, in cerebral, cardiac and renal ischaemia, in cerebral trauma, in chronic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), and in demyelinating diseases such as multiple sclerosis.
    Type: Application
    Filed: November 2, 2011
    Publication date: May 29, 2014
    Applicant: CENTRO CARDIOLOGICO MONZINO SpA
    Inventors: Mariapia Abbracchio, Ivano Eberini, Chiara Parravicini, Claudia Martini, Maria Letizia Trincavelli, Simona Daniele