Abstract: A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

Abstract: Disclosed herein are compositions for administering vaginally of an active agent or a salt to a subject comprising the active agent or salt thereof, a bioadhesive, and an emulsion. Provided herein are methods treating a disease of condition by administering vaginally to a subject a pharmaceutical composition, and kits comprising the pharmaceutical composition. Further provided are methods of localizing an active agent to the peritoneal cavity of a subject while minimizing systemic circulation of the active agent.

Abstract: A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

Abstract: The present invention relates to a hydroalcoholic gel comprising at least 70 weight % alcohol, between 5 and 10 weight % of an oil composition, between 0.15 and 6 weight % of a gelling agent and between than 0.01 and 0.1 weight % of a pH adjusting agent, and wherein the gelling agent consist of between 0.05 and 2.0 weight % of a carbomer and between 0.1 and 4.5 weight % of a cellulose polymer composition. Said hydroalcoholic gel is unique in that it destroys microorganisms and virus, moisturizes the skin, does not leave an oily residue and a tacky feel on the skin, and adheres firmly to the skin (even after washing) thereby providing a long-term disinfecting effect.

Abstract: A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

Abstract: A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.

Abstract: Disclosed herein are compositions for administering vaginally of an active agent or a salt to a subject comprising the active agent or salt thereof, a bioadhesive, and an emulsion. Also disclosed herein are methods treating a disease of condition by administering vaginally to a subject a pharmaceutical composition, and kits comprising the pharmaceutical composition.