Abstract: Disclosed is a process for the preparation of 6-?-fluoro pregnanes of formula I wherein R1 is an acyl group, R2 can be H, alpha methyl or beta methyl, and the dotted line can represent a double bond, comprising fluorination with electrophilic fluorinating agents in the 6 position of compounds of formula III, wherein R1, R2 and the dotted line have the meanings stated above, in an inert solvent, in the presence of a basic catalyst at temperatures ranging between 0 and 30° C.

Abstract: Disclosed is a process for the preparation of 6-?-fluoro pregnanes of formula I wherein R1 is an acyl group, R2 can be H, alpha methyl or beta methyl, and the dotted line can represent a double bond, comprising fluorination with electrophilic fluorinating agents in the 6 position of compounds of formula III, wherein R1, R2 and the dotted line have the meanings stated above, in an inert solvent, in the presence of a basic catalyst at temperatures ranging between 0 and 30° C.

Abstract: A method for destroying asbestos in mainly organic matrix asbestos-containing waste includes the steps of: preparing the asbestos-containing waste; preparing a supercritical aqueous phase; letting the asbestos and the primarily organic matrix of the asbestos-containing waste react with the aqueous phase for a time t in an appropriate reactor at a predetermined pressure P and temperature T to maintain the aqueous phase in supercritical condition; cooling and condensing the aqueous phase flowing out of the reactor; and separating the aqueous phase from any entrained solid products therein. The step of preparing the supercritical aqueous phase includes an additional step, in which an oxidizing compound is added in a predetermined concentration Cl, the pressure P is in a range from 25 to 27 MPa, and the temperature T is in a range from 600° C. to 650° C., causing the asbestos and the organic binder to be simultaneously destroyed.

Abstract: A method for destroying asbestos in mainly organic matrix asbestos-containing waste (ACW), which includes the steps of: preparing the asbestos-containing waste; preparing a supercritical aqueous phase; allowing asbestos and the primarily organic matrix of the asbestos-containing waste to react with the aqueous phase for a time t in an appropriate reactor at predetermined pressure P and temperature T to maintain the aqueous phase in supercritical conditions; cooling and condensing the aqueous phase flowing out of the reactor; and separating said aqueous phase from any entrained solid product therein. The step in which the supercritical aqueous phase is prepared includes an additional step, in which at least one oxidizing compound is added in a predetermined concentration C1, the pressure P is in a range from 25 to 27 MPa, and the temperature T is in a range from 600° C. to 650° C., causing the asbestos and the organic binder to be simultaneously destroyed.

Abstract: The invention relates to a process for the preparation of diphosphonic acids by reaction of a carboxylic acid with a mixture of phosphorous acid and phosphorus oxychloride in defined molar ratios and in the absence of solvents. The invention further relates to ibandronic acid monosodium salt in the amorphous form.

Abstract: The invention relates to a process for the preparation of diphosphonic acids by reaction of a carboxylic acid with a mixture of phosphorous acid and phosphorus oxychloride in defined molar ratios and in the absence of solvents. The invention futher relates to ibandronic acid monosodium salt in the amorphous form.

Abstract: Herein described is a process for the hydrothermal treatment of asbestos and/or materials containing asbestos in supercritical water (Supercritical Water, SCW), that provides for the withdrawal (3) of water from a tank (2), the transformation (5) of the water in supercritical water, the reaction of the supercritical water with asbestos or with material containing asbestos in a suitable environment (8) by means of a hydrolysis process, the cooling (14) of the waste water, the filtering (15) of the waste water, the collection of the waste water in a tank (17).