Patents by Inventor Simona Lanfranconi

Simona Lanfranconi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing rifaximin ?
    Patent number: 9708343
    Abstract: The present invention relates to a process for obtaining rifaximin ? comprising the following steps: a) reacting rifamycin O with 2-amino-4-picoline in the presence of a solvent mixture comprising water and a solvent selected from methyl isobutylketone, ethylacetate and a water soluble solvent; b) obtaining a rifaximin solution by removing the aqueous phase; c) obtaining rifaximin ? from the rifaximin solution, wherein when the solvent is a water soluble solvent, either methyl isobutylketone or ethylacetate is further added in step a). In another aspect the process of the invention relates to a process for obtaining the crystalline form ? of rifaximin comprising the following steps: i) contacting rifaximin or a rifaximin solution with exclusively ethylacetate, ii) obtaining the rifaximin in crystalline form ? by removing ethylacetate.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: July 18, 2017
    Assignee: Clarochem Ireland Ltd.
    Inventors: Enrico Vigano′, Renato Molteni, Simona Lanfranconi, Massimiliano Arrighi, Fabio Gatti
  • A PROCESS FOR PREPARING RIFAXIMIN K
    Publication number: 20160168166
    Abstract: The present invention relates to a process for obtaining rifaximin ? comprising the following steps: a) reacting rifamycin O with 2-amino-4-picoline in the presence of a solvent mixture comprising water and a solvent selected from methyl isobutylketone, ethylacetate and a water soluble solvent; b) obtaining a rifaximin solution by removing the aqueous phase; c) obtaining rifaximin ? from the rifaximin solution, wherein when the solvent is a water soluble solvent, either methyl isobutylketone or ethylacetate is further added in step a). In another aspect the process of the invention relates to a process for obtaining the crystalline form ? of rifaximin comprising the following steps: i) contacting rifaximin or a rifaximin solution with exclusively ethylacetate, ii) obtaining the rifaximin in crystalline form ? by removing ethylacetate.
    Type: Application
    Filed: August 1, 2014
    Publication date: June 16, 2016
    Inventors: Enrico VIGANO', Renato MOLTENI, Simona LANFRANCONI, Massimilliano ARRIGHI, Fabio GATTI
  • Polymorph of rifaximin and process for the preparation thereof
    Patent number: 8877770
    Abstract: The present invention relates to a new polymorph of Rifaximin, designated ?, and to a process for the preparation thereof. Under certain aspects, the invention also relates to pharmaceutical compositions comprising an effective amount of the polymorphic form ? of Rifaximin and a pharmaceutically acceptable carrier and its uses in the treatment of gastrointestinal conditions.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: November 4, 2014
    Assignee: Clarochem Ireland Limited
    Inventors: Enrico Vigano', Renato Molteni, Simona Lanfranconi, Massimiliano Arrighi, Fabio Gatti
  • POLYMORPH OF RIFAXIMIN AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20140107144
    Abstract: The present invention relates to a new polymorph of Rifaximin, designated ?, and to a process for the preparation thereof. Under certain aspects, the invention also relates to pharmaceutical compositions comprising an effective amount of the polymorphic form ? of Rifaximin and a pharmaceutically acceptable carrier and its uses in the treatment of gastrointestinal conditions.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 17, 2014
    Applicant: CLAROCHEM IRELAND LIMITED
    Inventors: Enrico Vigano, Renato Molteni, Simona Lanfranconi, Massimiliano Arrighi, Fabio Gatti
  • Process for the preparation of nateglinide, preferably in B-form
    Patent number: 7425648
    Abstract: The present invention relates to a process for the preparation of nateglinide, preferably in B-form, substantially free from the H-form, comprising three steps starting from D-phenylalanine methyl ester or a salt thereof.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: September 16, 2008
    Assignee: A.M.S.A. Anonima Materie Sintetiche E. Affini S.p.A.
    Inventors: Enrico Vigano', Enrica Pizzatti, Simona Lanfranconi, Renato Molteni, Ernesto Landonio
  • Process for synthesising aminoadamantanes
    Patent number: 7405324
    Abstract: The present invention concerns a new process for synthesising aminoadamantanes of formula I in which R1 and R2 are identical or different and are H or a straight or branched alkyl group comprising from 1 to 6 carbon atoms, and addition salts thereof with inorganic or organic acids, in particular memantine hydrochloride (1-amino-3,5-dimethyladamantane hydrochloride).
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: July 29, 2008
    Assignee: A.M.S.A. Anonima Materie Sintetiche E. Afini S.p.A.
    Inventors: Enrico Vigano′, Ernesto Landonio, Simona Lanfranconi, Renato Molteni
  • Process for synthesising aminoadamantanes
    Publication number: 20060258885
    Abstract: The present invention concerns a new process for synthesising aminoadamantanes of formula I in which R1 and R2 are identical or different and are H or a straight or branched alkyl group comprising from 1 to 6 carbon atoms, and addition salts thereof with inorganic or organic acids, in particular memantine hydrochloride (1-amino-3,5-dimethyladamantane hydrochloride).
    Type: Application
    Filed: May 10, 2006
    Publication date: November 16, 2006
    Inventors: Enrico Vigano, Ernesto Landonio, Simona Lanfranconi, Renato Molteni
  • Process for the preparation of nateglinide, preferably in B-form
    Publication number: 20060148902
    Abstract: The present invention relates to a process for the preparation of nateglinide, preferably in B-form, substantially free from the H-form, comprising three steps starting from D-phenylalanine methyl ester or a salt thereof.
    Type: Application
    Filed: January 3, 2005
    Publication date: July 6, 2006
    Inventors: Enrico Vigano', Enrica Pizzatti, Simona Lanfranconi, Renato Molteni, Ernesto Landonio
  • Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE)
    Patent number: 6599922
    Abstract: Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: July 29, 2003
    Assignee: A.M.S.A. Anonima Materie Sintetiche e Affini S.p.A.
    Inventors: Enrico Vigano, Enrica Pizzatti, Renato Molteni, Simona Lanfranconi
  • Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE)
    Publication number: 20030032835
    Abstract: Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.
    Type: Application
    Filed: August 8, 2002
    Publication date: February 13, 2003
    Inventors: Enrico Vigano, Enrica Pizzatti, Renato Molteni, Simona Lanfranconi