Patents by Inventor Simona SESTITO

Simona SESTITO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • H2S-BASED THERAPEUTIC AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20210070730
    Abstract: The present invention concerns the field of neurodegenerative diseases, and in particular relates to compounds, pharmaceutical compositions and their uses in the protection of neuronal cells from inflammation and from oxidative stress in the early stage of Parkinson's Disease as well as in Alzheimer's Disease.
    Type: Application
    Filed: October 8, 2018
    Publication date: March 11, 2021
    Applicant: INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.
    Inventors: Simona Rapposelli, Simona Sestito, Vincenzo Calderone, Guido Puricelli
  • 2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1
    Patent number: 10351548
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumors such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 16, 2019
    Assignee: International Society for Drug Development S.R.L.
    Inventors: Simona Sestito, Simona Daniele, Claudia Martini, Simona Rapposelli, Guido Puricelli
  • 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA
    Publication number: 20190160049
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) in the treatment of pathologies which require a dual inhibitor of PDK1/AurA enzymes such as for instance tumours, particularly glioblastoma.
    Type: Application
    Filed: June 8, 2017
    Publication date: May 30, 2019
    Inventors: Simona SESTITO, Simona DANIELE, Claudia MARTINI, Simona RAPPOSELLI, Guido PURICELLI
  • 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1
    Publication number: 20180155320
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumours such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 7, 2018
    Inventors: Simona SESTITO, Simona DANIELE, Claudia MARTINI, Simona RAPPOSELLI, Guido PURICELLI