Patents by Inventor Simona Sputore

Simona Sputore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
    Patent number: 8609644
    Abstract: Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: December 17, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Marco Torri, Silvia Armaroli, Leonardo Banfi, Giuseppe Bianchi, Giulio Carzana, Patrizia Ferrari, Rosamaria Michaeletti, Simona Sputore, Maria Pia Zappavigna
  • AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS
    Publication number: 20110053902
    Abstract: Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
    Type: Application
    Filed: April 11, 2007
    Publication date: March 3, 2011
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Alberto Cerri, Marco Torri, Silvia Armaroli, Leonardo Banfi, Giuseppe Bianchi, Giulio Carzana, Patrizia Ferrari, Rosamaria Michaeletti, Simona Sputore, Maria Pia Zappavigna
  • Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6, 17-dione and its analogues
    Patent number: 6384250
    Abstract: An improved process is described for the preparation of compounds with general formula (I) and particularly for the preparation of the compound (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione, in which n=1 and R1=R2=H
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 7, 2002
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mauro Gobbini, Giulio Carzana, Simona Sputore
  • Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione and its analogues
    Publication number: 20010056182
    Abstract: An improved process is described for the preparation of compounds with general formula (I) and particularly for the preparation of the compound (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione, in which n=1 and R1=R2=H.
    Type: Application
    Filed: May 10, 2001
    Publication date: December 27, 2001
    Inventors: Mauro Gobbini, Giulio Carzana, Simona Sputore
  • 6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same
    Patent number: 5914324
    Abstract: 6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R.sup.1, R.sup.2 and R.sup.3 are as defined herein.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: June 22, 1999
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Sergio De Munari, Elena Folpini, Marco Frigerio, Piero Melloni, Fulvio Serra, Simona Sputore
  • Process for the oxidation of primary and secondary alcohols to aldehydes and ketones and for the oxidation of 1,2-diols to .alpha.-ketols and .alpha.-diketones
    Patent number: 5510538
    Abstract: A process for the selective oxidation of a primary or secondary alcohol to an aldehyde or ketone and for the oxidation of a 1,2-diol to an .alpha.-ketol or .alpha.-diketone, which comprises contacting the alcohol or 1,2-diol with o-iodoxybenzoic acid. This process is suited for selective oxidation of alcohols containing easily oxidizable groups, such as amino or thioether groups and easily oxidizable heterocycles.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: April 23, 1996
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Marco Frigerio, Simona Sputore, Marco Santagostino