Patents by Inventor Simone BALZER LE

Simone BALZER LE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic MRNA leaders
    Patent number: 10472638
    Abstract: The present invention provides a synthetic mRNA leader for enhancing the expression of a gene encoding a desired protein, vectors comprising said synthetic mRNA leader and methods of producing a desired gene product using said synthetic mRNA leader and vector, said method comprising expressing said gene using a synthetic mRNA leader which comprises from 5? to 3?: (i) a first mRNA leader sequence element; (ii) a spacer region; and (iii) a second mRNA leader sequence element; wherein said first mRNA leader sequence element is a modified transcription-stimulating mRNA leader capable of enhancing transcription of a gene relative to an unmodified reference mRNA leader sequence and/or said second mRNA leader element is a modified translation-stimulating mRNA leader capable of enhancing the translation of a gene transcript relative to an unmodified reference mRNA leader sequence.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: November 12, 2019
    Assignee: VECTRON BIOSOLUTIONS AS
    Inventors: Rahmi Lale, Svein Valla, Simone Balzer Le
  • SYNTHETIC MRNA LEADERS
    Publication number: 20170022509
    Abstract: The present invention provides a synthetic mRNA leader for enhancing the expression of a gene encoding a desired protein, vectors comprising said synthetic mRNA leader and methods of producing a desired gene product using said synthetic mRNA leader and vector, said method comprising expressing said gene using a synthetic mRNA leader which comprises from 5? to 3?: (i) a first mRNA leader sequence element; (ii) a spacer region; and (iii) a second mRNA leader sequence element; wherein said first mRNA leader sequence element is a modified transcription-stimulating mRNA leader capable of enhancing transcription of a gene relative to an unmodified reference mRNA leader sequence and/or said second mRNA leader element is a modified translation-stimulating mRNA leader capable of enhancing the translation of a gene transcript relative to an unmodified reference mRNA leader sequence.
    Type: Application
    Filed: April 2, 2015
    Publication date: January 26, 2017
    Applicant: VECTRON BIOSOLUTIONS AS
    Inventors: Rahmi LALE, Svein VALLA, Simone BALZER LE