Abstract: Provided herein are compositions and methods for detecting exhaled microRNAs for identifying lung diseases such as cancer, asthma, and chronic obstructive pulmonary disease.

Abstract: In an embodiment an apparatus includes a delimiting device and a holding device configured to hold the delimiting device at a distance above an optoelectronic light-emitting device and form a layer of a material provided in a flowable state between the delimiting device and the light-emitting device, wherein a bottom side of the delimiting device, which faces the light-emitting device, has a structuring so that a structure complementary to the structuring is producible on an upper side of the layer.

Abstract: Disclosed herein are substrate-promiscuous regulators which have been engineered to function as highly efficient biosensors. These engineered biosensors are significantly more specific to the target ligand than their naturally occurring counterparts, and are able to generate a detectable output signal upon exposure to the input signal (target ligand). Also disclosed of methods of making engineered biosensors based on a naturally occurring substrate-promiscuous regulator. Also disclosed are methods of using these biosensors to make a product, such as cell-based bioengineering platforms. Lastly, disclosed are kits, nucleic acids, and proteins related to the biosensors disclosed herein.

Abstract: Provided herein are uses for an immunostimulatory compound for stimulating an immune response when administered either alone or as an adjuvant in a vaccine. Also provided herein are kits, compositions, and methods of administration for the compound described for proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease, in a subject in need thereof. Using the compound as a vaccine adjuvant enables effective immunization in vulnerable populations.

Abstract: Provided herein are uses for an immunostimulatory compound for stimulating an immune response when administered either alone or as an adjuvant in a vaccine. Also provided herein are kits, compositions, and methods of administration for the compound described.

Abstract: A coupling method for ends of electrical cables of an inductive winding. The cables are constituted by an electrically conducting core covered by a layer of dielectric material. The method comprises a first step of juxtaposing side faces of distinct ends that are arranged substantially parallel, and a second step of welding the ends that have the faces juxtaposed. The method consists of providing, before the first step, at least one engraved groove on the surface of at least one side face. The at least one groove will determine an asymmetry in the respective wettability on the face, consisting of a greater wettability in the longitudinal direction than in the transverse direction.

Abstract: This invention relates to non-naturally occurring methyltransferase, wherein said methyltransferase can methylate norbelladine to form 4-O'Methylnorbelladine. The invention is also drawn to a biosensor for detecting 4-O'Methylnorbelladine, wherein the biosensor comprises an engineered substrate-promiscuous regulator, wherein said substrate-promiscuous regulator has been engineered to interact more efficiently with 4-O'Methylnorbelladine than does a naturally occurring substrate promiscuous regulator; and further wherein the biosensor is engineered to provide an output signal, wherein said output signal is generated when the biosensor interacts with 4-O'Methylnorbelladine.

Abstract: Disclosed herein are engineered methyltransferases which are capable of methylating more than two sites in a benzylisoquinoline alkaloid or precursor thereof. Also disclosed are of methods of making benzylisoquinoline alkaloids using the engineered methyltransferase. Lastly, disclosed are kits, nucleic acids, and proteins related to the methyltransferases disclosed herein.

Abstract: The present disclosure relates to a neural network comprising a first synapse circuit (106) configured to apply a first time delay to a first input signal (READ1) using a first resistive memory element (108) and to generate a first output signal at an output of the first synapse circuit by applying a first weight to the delayed first input signal; and a second synapse circuit (106) configured to apply a second time delay, different to the first time delay, to the first input signal, or to a second input signal (READN), using a second resistive memory element (108) and to generate a second output signal at an output of the second synapse circuit by applying a second weight to the delayed second input signal.

Abstract: Transport Layer Security (TLS) connection establishment between a client and a server for a new session is enabled using an ephemeral (temporary) key pair. In response to a request, the server generates a temporary certificate by signing an ephemeral public key using the server's private key. A certificate chain comprising at least the temporary certificate that includes the ephemeral public key, together with a server certificate, is output to the client by the server, which acts as a subordinate Certificate Authority. The client validates the certificates, generates a session key and outputs the session key wrapped by the ephemeral public key. To complete the connection establishment, the server applies the ephemeral private key to recover the session key derived at the client for the new session. The client and server thereafter use the session key to encrypt and decrypt data over the link. The ephemeral key pair is not reused.

Abstract: The present disclosure relates to a neural network comprising a first synapse circuit (106) configured to apply a first time delay to a first input signal (READ1) using a first resistive memory element (108) and to generate a first output signal at an output of the first synapse circuit by applying a first weight to the delayed first input signal; and a second synapse circuit (106) configured to apply a second time delay, different to the first time delay, to the first input signal, or to a second input signal (READN), using a second resistive memory element (108) and to generate a second output signal at an output of the second synapse circuit by applying a second weight to the delayed second input signal.

Abstract: Methods for producing hydrocarbons from subterranean reservoirs utilizing a production well having a plurality of fluid-inlet components spaced apart to define a plurality of production-well fluid-inlet zones. An injection fluid comprising a solvent is injected into the reservoir, resulting in a drainage fluid with a liquid phase and a gas phase occupying one or more of the production-well fluid-inflow zones. The production fluid is produced at a production-flow rate via a pump, and the gas phase:liquid phase ratio of the production fluid is modulated by orchestrating variations in the pump speed and one or more of the plurality of fluid-inlet components to prioritize hydraulic communication with a subset of the plurality of production-well fluid-inlet zones.

Abstract: A method for coating a medical device includes applying a second layer that includes a second drug on a first layer of on the medical device. The first layer includes a first drug, which may be in crystalline form. By selecting an appropriate solvent use in applying the second layer and appropriate process conditions, the second layer may be applied such that the first drug retains one or more therapeutic properties. For example, the second layer may be applied such that the first drug maintains its crystalline form. The first and second layers may be free of polymer.

Abstract: Examples provide a modular tray table apparatus associated with a console of a seat unit. A tray table carrier unit is removably mounted to a portion of the console. A tray table support element is coupled to the carrier unit and a tray table. The tray table support element movably supports the tray table. A linear displacement mechanism is disposed between the tray table and the tray table support element. The tray table slides along a linear displacement path between a fully retracted configuration and at least one deployed configuration. A rotational displacement mechanism disposed between the tray table and the tray table support element. The tray table slides along a rotational displacement path defined by at least one rotational guide between a linear configuration of the tray table and a substantially perpendicular configuration of the tray table when the tray table is in a fully deployed configuration.

Abstract: Methods are provided for producing hydrocarbons and recovering solvent from a subterranean reservoir that is penetrated by an injection well and a production well, in which a production phase involves injecting solvent (and optionally steam) to mobilize viscous hydrocarbons and a solvent-recovery phase involves non-condensable gas injection. The production phase and the solvent-recovery phase are each defined by an injection profile. The solvent-recovery-phase injection profile is selected: (i) based on the production-phase injection profile, and (ii) to ensure the pressure/temperature conditions in proximity to the production well favor gas-phase solvent recovery.

Abstract: Systems and methods are disclosed for associating a plurality of Internet-enabled devices with a common user profile for targeting Internet content or advertising. One method includes: receiving, from a plurality of Internet-enabled devices, a plurality of requests for electronic content or advertising; extracting, from each of the plurality of requests, a source IP address and a unique identifier associated with the respective Internet-enabled device; for each source IP address for which requests were received over a predetermined time period from a number of Internet-enabled devices below a threshold number of devices, identifying each possible pair of devices from which requests were received; and for each possible pair of devices, calculating a probability that the pair of devices are owned or operated by a common user.

Abstract: Examples provide a modular tray table apparatus associated with a console of a seat unit. A tray table carrier unit is removably mounted to a portion of the console. A tray table support element is coupled to the carrier unit and a tray table. The tray table support element movably supports the tray table. A linear displacement mechanism is disposed between the tray table and the tray table support element. The tray table slides along a linear displacement path between a fully retracted configuration and at least one deployed configuration. A rotational displacement mechanism disposed between the tray table and the tray table support element. The tray table slides along a rotational displacement path defined by at least one rotational guide between a linear configuration of the tray table and a substantially perpendicular configuration of the tray table when the tray table is in a fully deployed configuration.

Abstract: A method, a computer program product, and a system for binding post-quantum certificates to traditional certificates. The method includes selecting a traditional certificate in a certificate chain owned by an owner. The method also includes calculating a fingerprint of the traditional certificate. The method further includes generating a post-quantum certificate with identical information fields as the traditional certificate, and populating a serial number of the post-quantum certificate using the fingerprint. The post-quantum certificate acts as an extension of the first traditional certificate providing authentication and validation between a client and a server using post-quantum capable signing algorithms.

Abstract: A method for treating pest infestation of crops includes withholding all light from the crops and, during the withholding, applying a burst of ultraviolet light to the crops. A method for reducing pests includes turning off all lighting arranged to apply growth light to the crops, applying a burst of ultraviolet light to the crops and turning on the lighting arranged to apply growth light to the crops. A system for treating pest infestation of crops includes a plurality of ultraviolet light sources and a controller configured to energize the ultraviolet light sources to apply a burst of ultraviolet light to the crops.

Abstract: Systems and methods are disclosed for associating a plurality of Internet-enabled devices with a common user profile for targeting Internet content or advertising. One method includes: receiving, from a plurality of Internet-enabled devices, a plurality of requests for electronic content or advertising; extracting, from each of the plurality of requests, a source IP address and a unique identifier associated with the respective Internet-enabled device; for each source IP address for which requests were received over a predetermined time period from a number of Internet-enabled devices below a threshold number of devices, identifying each possible pair of devices from which requests were received; and for each possible pair of devices, calculating a probability that the pair of devices are owned or operated by a common user.