Patents by Inventor Simone Giacobbe

Simone Giacobbe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroquinolines as NMDA antagonists
    Patent number: 5977136
    Abstract: Compounds of formula (I) or a salt, or metabolically labile ester thereof, processes for the preparation thereof and their use as antagonists of excitatory amino acids.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: November 2, 1999
    Assignee: Glaxo Wellcome SpA
    Inventors: Romano Di Fabio, Simone Giacobbe, Barbara Bertani, Fabrizio Micheli
  • Indole derivatives and pharmaceutical use thereof
    Patent number: 5374648
    Abstract: The invention relates to compounds of formula (I). ##STR1## or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.1 or COR.sub.1 wherein R.sub.1 represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2;A represents an ethynyl group or an optionally substituted ethenyl, orcyclopropyl group or a substituted ethenyl group;X represents --O-- or NH;R.sub.2 represents an aryl group and when X represents an oxygen atom R.sub.2 may also represent a hydrogen atom or an alkyl group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: December 20, 1994
    Assignee: Glaxo S.p.A.
    Inventors: Alfredo Cugola, Giovanni Gaviraghi, Simone Giacobbe