Patents by Inventor Simone Giovani

Simone Giovani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions for the treatment of cystic fibrosis
    Patent number: 11999734
    Abstract: The present invention relates to compounds of Formula (Ia) or pharmaceutically acceptable salts, hydrates, solvates, clathrates, polymorphs, stereoisomers thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (Ia) and the use of compounds of Formula (Ib), in particular to modulate CFTR protein or ABC protein activities.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 4, 2024
    Assignees: Fondazione Istituto Italiano Di Tecnologia, Istituto Giannina Gaslini, Fondazione Per La Ricerca Sulla Fibrosi Cistica—Onlus
    Inventors: Tiziano Bandiera, Fabio Bertozzi, Francesca Giacomina, Simone Giovani, Federico Sorana, Emanuela Caci, Loretta Ferrera, Nicoletta Pedemonte, Luis Juan Vicente Galietta
  • Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents
    Patent number: 11634400
    Abstract: The present invention relates to derivatives of the sesquiterpene lactone micheliolide, methods and compositions for their preparation, and methods for using the micheliolide derivatives in pharmaceutical compositions as anticancer and anti-inflammatory agents. The invention also relates to methods for producing micheliolide derivatives modified at positions C2 and C14. The invention also relates to methods for producing parthenolide derivatives modified at positions C2 and C14 in conjunction with modifications at position C13, via chemoenzymatic methods. The invention further relates to methods for using parthenolide derivatives for treating cancer and inflammatory diseases.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 25, 2023
    Assignee: University of Rochester
    Inventors: Rudi Fasan, Simone Giovani, Hanan Alwaseem
  • COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS
    Publication number: 20210292324
    Abstract: The present invention relates to compounds of Formula (Ia) or pharmaceutically acceptable salts, hydrates, solvates, clathrates, polymorphs, stereoisomers thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (Ia) and the use of compounds of Formula (Ib), in particular to modulate CFTR protein or ABC protein activities.
    Type: Application
    Filed: July 12, 2019
    Publication date: September 23, 2021
    Inventors: Tiziano Bandiera, Fabio Bertozzi, Francesca Giacomina, Simone Giovani, Federico Sorana, Emanuela Caci, Loretta Ferrera, Nicoletta Pedemonte, Luis Juan Vicente Galietta
  • MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS
    Publication number: 20200277270
    Abstract: The present invention relates to derivatives of the sesquiterpene lactone micheliolide, methods and compositions for their preparation, and methods for using the micheliolide derivatives in pharmaceutical compositions as anticancer and anti-inflammatory agents. The invention also relates to methods for producing micheliolide derivatives modified at positions C2 and C14. The invention also relates to methods for producing parthenolide derivatives modified at positions C2 and C14 in conjunction with modifications at position C13, via chemoenzymatic methods. The invention further relates to methods for using parthenolide derivatives for treating cancer and inflammatory diseases.
    Type: Application
    Filed: August 17, 2018
    Publication date: September 3, 2020
    Inventors: Rudi Fasan, Simone Giovani, Hanan Alwaseem