Patents by Inventor Simone KUHNLE

Simone KUHNLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NSD3 INHIBITORS FOR TREATMENT OF CANCERS
    Publication number: 20170007595
    Abstract: The present invention relates to the use of NSD3i inhibitors for the treatment of cancer. In particular, the present invention relates to methods, kits and compositions comprising NSD3 inhibitors to treat cancers dependent on NSD3, in particular subjects with NUT midline carcinoma (NMC) and subjects with NSD3/NUT or BRD4/NUT or BRD3/NUT fusion genes, as well as subjects with BRD4-dependent (but NUT-independent cancers). The present invention also relates to methods, kits and compositions comprising BET inhibitors for the treatment of subjects with NSD3/NUT fusion genes. Other aspects of the invention relate to assays and methods to identify an inhibitor of NSD3 which disrupts or decreases the interaction of the NSD3 protein with the ET do main of BRD4.
    Type: Application
    Filed: January 23, 2015
    Publication date: January 12, 2017
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Christopher A. FRENCH, Peter M. HOWLEY, Erica Marlene WALSH MICHEL, Shaila RAHMAN, Simone KUHNLE