Abstract: Apparatus, systems and methods for smart air signature detection and management in at least one room within a building are disclosed herein. In one embodiment, an apparatus for monitoring, reporting and modifying the air in at least one room with at least one entrance/exit door within a building is disclosed. The apparatus comprises a plurality of sensors configured for sensing information related to a plurality of characteristics of the air in at least one room; a processor configured for collecting and processing the information to generate air-related data; and a transceiver configured for communicating the air-related data to a user device of a user and configured for communicating with a network of one or more devices that can modify the air in the at least one room. Systems and methods related thereto are disclosed herein.