Patents by Inventor Simone Zaramella

Simone Zaramella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of eslicarbazepine and eslicarbazepine acetate
    Patent number: 9845293
    Abstract: Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: December 19, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Simone Zaramella, Emiliano Rossi, Ottorino De Lucchi, Siro Serafini
  • PROCESS FOR THE PREPARATION OF ESLICARBAZEPINE AND ESLICARBAZEPINE ACETATE
    Publication number: 20170305860
    Abstract: An improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts is provided.
    Type: Application
    Filed: February 23, 2016
    Publication date: October 26, 2017
    Inventors: Simone ZARAMELLA, Emiliano ROSSI, Ottorino DE LUCCHI, Siro SERAFINI
  • Process for the preparation of key intermediates of omarigliptin
    Patent number: 9481680
    Abstract: An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) wherein R1 is propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV) by an amination reaction to a compound of formula (III), which is then protected to provide a compound of formula (II), which is then alkylated to provide the compound of formula (I).
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: November 1, 2016
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A
    Inventors: Ottorino De Lucchi, Enrico Rosso, Simone Zaramella, Stefano Tartaggia
  • PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN
    Publication number: 20160200727
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of the active pharmaceutical ingredient named Omarigliptin.
    Type: Application
    Filed: January 19, 2015
    Publication date: July 14, 2016
    Inventors: Ottorino DE LUCCHI, Enrico ROSSO, Simone ZARAMELLA, Stefano TARTAGGIA
  • Process for the preparation and resolution of mandelic acid derivatives
    Patent number: 7960582
    Abstract: The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl.
    Type: Grant
    Filed: November 25, 2004
    Date of Patent: June 14, 2011
    Assignee: AstraZeneca AB
    Inventors: Hans Jorgen Blixt, Bo Lars Gustaf Bosson, Roberto Guiseppe Paolo Gatti, Simone Zaramella, Michael William Senior, Kurt Vogtli, Andrea Zistler
  • Process
    Publication number: 20080312457
    Abstract: The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl.
    Type: Application
    Filed: November 25, 2004
    Publication date: December 18, 2008
    Inventors: Hans Jorgen Blixt, Bo Lars Gustaf Bosson, Roberto Guiseppe Paolo Gatti, Simone Zaramella, Michael William Senior, Kurt Vogtli, Andrea Zistler