Patents by Inventor Simonetta Sipione

Simonetta Sipione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neuroprotective ganglioside compositions for use in treating huntington's disease
    Patent number: 9023812
    Abstract: Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine stretch in the protein huntingtin (Htt). HD neurons are dysfunctional at multiple levels and have increased susceptibility to stress and apoptotic stimuli. As described therein there is provided compound(s), composition(s), methods and/or kits for the treatment and/or diagnosis of Huntington's disease.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: May 5, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Simonetta Sipione, Vittorio Maglione
  • NEUROPROTECTIVE GANGLIOSIDE COMPOSITIONS FOR USE IN TREATING OR DIAGNOSING HUNTINGTON'S DISEASE
    Publication number: 20120283199
    Abstract: Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine stretch in the protein huntingtin (Htt). HD neurons are dysfunctional at multiple levels and have increased susceptibility to stress and apoptotic stimuli. As described therein there is provided compound(s), composition(s), methods and/or kits for the treatment and/or diagnosis of Huntington's disease.
    Type: Application
    Filed: August 20, 2010
    Publication date: November 8, 2012
    Applicant: THE GOVERNERS OF THE UNIVERSITY OF ALBERTA
    Inventors: Simonetta Sipione, Vittorio Maglione
  • COMPOSITIONS FOR AND METHODS OF GRAZYME B INHIBITION
    Publication number: 20110083201
    Abstract: The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.
    Type: Application
    Filed: September 7, 2010
    Publication date: April 7, 2011
    Inventors: Ray V. Rajotte, R. Chris Bleackley, Greg Korbutt, Sarah J. Lord, Simonetta Sipione, Katia Carmine-Simmen, Fabrizio Giuliani
  • Compositions for and methods of granzyme B inhibition
    Publication number: 20070104699
    Abstract: The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.
    Type: Application
    Filed: September 26, 2006
    Publication date: May 10, 2007
    Applicant: University of Alberta
    Inventors: Ray Rajotte, R. Bleackley, Greg Korbutt, Sarah Lord, Simonetta Sipione, Katia Carmine-Simmen, Fabrizio Giuliani